A5101936833- Sirtuins and Resveratrol in Medicine
- Adipose Tissue and Metabolism
- Cardiac Ischemia and Reperfusion
- Autophagy in Disease and Therapy
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Function and Risk Factors
- Phytoestrogen effects and research
- Chemotherapy-induced cardiotoxicity and mitigation
- Ferroptosis and cancer prognosis
- Transplantation: Methods and Outcomes
- Cancer-related molecular mechanisms research
- Advanced Glycation End Products research
- Ion Channels and Receptors
- Cholesterol and Lipid Metabolism
- Phytochemicals and Antioxidant Activities
- Colorectal Cancer Screening and Detection
- Congenital gastrointestinal and neural anomalies
- GDF15 and Related Biomarkers
- Signaling Pathways in Disease
- Sphingolipid Metabolism and Signaling
- Fuel Cells and Related Materials
- Organ Transplantation Techniques and Outcomes
- Chronic Kidney Disease and Diabetes
- Intestinal Malrotation and Obstruction Disorders
- Alcohol Consumption and Health Effects
Hubei University of Science and Technology
2014-2025
Second Hospital of Shandong University
2019-2023
Handan College
2023
Lanzhou University Second Hospital
2019
South China Normal University
2019
Lanzhou University
2019
Reperfusion strategies in acute myocardial infarction (AMI) can cause a series of additional clinical damage, defined as ischemia/reperfusion (I/R) injury, and thus there is need for effective therapeutic methods to attenuate I/R injury. miR-26a-5p has been proven be an essential regulator biological processes different cell types. Nevertheless, the role injury not yet reported. We established model vitro vivo. In vitro, we used cardiomyocytes simulate using hypoxia/reoxygenation (H/R)...
Colorectal cancer stem cells (CCSCs) play important roles in the prognosis, chemoresistance, and treatment failure of colorectal (CRC). Ferroptosis is an effective for CCSCs. Vitamin D (VD) reportedly inhibits colon cell proliferation. However, information on relationship between VD ferroptosis CCSCs not well documented. In this study, we aimed to understand effect To end, treated with different concentrations performed spheroid formation assay transmission electron microscopy determined...
Background/Aims: Diabetic cardiomyopathy is associated with increased apoptosis and suppressed autophagy in cardiac cells. The polyphenol resveratrol has shown beneficial effects various cardiovascular diseases. This study investigated if protected cells by modulating the context of diabetes. Methods: H9c2 myoblast were exposed to high glucose combined palmitate. Autophagy was evaluated estimating LC3-II/I ratio, P62 protein levels, LC3 fluorescent puncta. Apoptosis assessed using terminal...
Background Diabetic cardiomyopathy (DCM) suggests a direct cellular insult to myocardium. Apoptosis is considered as one of the hallmarks DCM. Oxidative stress plays key role in pathogenesis In this study, we explored prevention myocardial apoptosis by crude extract from Flos Puerariae (FPE) experimental diabetic mice. Methods Experimental model was induced intraperitoneally injection streptozotocin (STZ, 50 mg/kg/day) for five consecutive days C57BL/6J FPE (100, 200 mg/kg) orally...
Inflammatory cytokines are implicated in the development of atherosclerosis and cardiomyocyte injury during acute myocardial infarction (AMI). This study aimed to investigate correlation eight common inflammatory with major adverse cardiac event (MACE) risk further establish a prognostic model AMI patients.Serum samples 210 patients 20 angina pectoris were, respectively, collected at admission, detect tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-17A,...
Aim: This study aimed to evaluate association of homocysteine (Hcy) with major adverse cardiac event (MACE) risk in acute myocardial infarction (AMI). Methods: Serum Hcy data from 196 AMI and 20 angina pectoris patients were retrieved a hospital's electronic system. attended median 21.2-month follow-up. Results: was elevated compared (p = 0.020). In patients, positively related total cholesterol, low-density lipoprotein C-reactive protein, infarct size, TNF-α IL-6, while inversely linked...
Background The effect of Flos Puerariae extract (FPE) on alcohol metabolism, hepatic injury, and memory impairment was assessed following acute ethanol (EtOH) intoxication in mice. Methods model EtOH established by intragastric administration with 8 g/kg FPE orally administrated (gavage) once a day for 7 consecutive days. Mice were randomly divided into 4 groups: control group, groups (100, 200 mg/kg). Alcohol tolerance time, blood concentration, the activities dehydrogenase (ADH) aldehyde...
Ferroptosis is a promising colorectal cancer (CRC) treatment strategy; however, its value in prognosis remains at an exploratory stage. Little research has been conducted on vitamin D and ferroptosis, although shown to inhibit CRC through various mechanisms. A retrospective study was using RNA-seq profiles corresponding clinical information of patients retrieved from TCGA GEO databases.We used R package process analyze the data. We established prognostic signature with elastic network...
Synchronous neoplastic lesions are usually present in patients with colorectal cancer (CRC) at diagnosis or postoperative follow-up endoscopy. However, few studies have been published about the clinicopathological features of synchronous lesions, especially those advanced neoplasia. This study aimed to describe CRC because this knowledge may be useful for preventing development metachronous cancer.We retrospectively reviewed 261 primary cases referred our hospital during a 4-year period....
In type 2 diabetes mellitus (T2DM), oxidative stress induces endothelial dysfunction (ED), which is closely related to the formation of atherosclerosis. However, there are few effective drugs prevent and cure it. Citronellal (CT) an aromatic active substance extracted from citronella plants. Recently, CT has been shown ED, but underlying mechanism remains unclear. The purpose this study was investigate whether ameliorated T2DM-induced ED by inhibiting TRPM2/NHE1 signal pathway. Transient...
Linaclotide, a guanylate cyclase C agonist that improves the symptoms of irritable bowel syndrome with predominant constipation (IBS-C), has been recently approved for IBS-C treatment. This study aimed to report real-world data on linaclotide treatment in China.This was prospective multicentre effectiveness patients from 10 primary medical institutions. Changes defecation, abdominal symptoms, IBS symptom severity scale (IBS-SSS), quality life questionnaire (IBS-QOL), Zung Self-Rating Anxiety...
Saxagliptin (SAX) can protect against tissue damage caused by diabetic nephropathy. However, whether this compound restore kidney function, and its specific mechanism of action remain unclear. The present study explored the therapeutic effects mechanisms SAX. Male Wistar rats (8 weeks old) were randomly divided into following groups: A control group (n=10); a with streptozocin‑induced diabetes mellitus (DM) treated saline (n=20); DM SAX (n=20). Following 20 treatment, renal function extent...
Background: Previous studies have shown that Puerarin plays a key role in protecting humans and animals from cardiovascular diseases. The therapeutic effects (protective cardiomyocytes) of various diseases mainly through the regulation Na+, K+, Ca2+ channels concentration these ions cardiomyocytes, but exact mechanism is unclear. Purpose: In present study, we identified an animal model experimental heart failure explored its underlying mechanisms.Study design Methods: rats was induced by...
Background: Previous studies have shown that Puerarin plays a key role in protecting humans and animals from cardiovascular diseases. The therapeutic effects (protective cardiomyocytes) of various diseases mainly through the regulation Na+, K+, Ca2+ channels concentration these ions cardiomyocytes, but exact mechanism is unclear. Purpose: In present study, we identified an animal model experimental heart failure explored its underlying mechanisms.Study design Methods: rats was induced by...