A5101763125- Ferroptosis and cancer prognosis
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Eosinophilic Esophagitis
- Epigenetics and DNA Methylation
- Gastroesophageal reflux and treatments
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Innovations in Medical Education
- Innovative Teaching Methods
- Simulation-Based Education in Healthcare
- Corneal Surgery and Treatments
- Liver Disease Diagnosis and Treatment
- RNA Research and Splicing
- Pharmacogenetics and Drug Metabolism
- Circular RNAs in diseases
- Gastrointestinal motility and disorders
- Virology and Viral Diseases
- Vitamin D Research Studies
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Screening and Detection
Second Hospital of Shandong University
2017-2024
Zhongnan Hospital of Wuhan University
2018-2024
Wuhan University
2018-2024
Affiliated Hospital of Hebei University
2024
Tobacco Research Institute
2022-2024
University of Benin
2024
Guangzhou Center for Disease Control and Prevention
2023
Hubei Provincial Center for Disease Control and Prevention
2018-2022
Scholar Rock (United States)
2021
Nanchang University
2021
Abstract Background Hepatocellular carcinoma (HCC) is one of the most prevalent and inflammation-associated cancers. The tumor microenvironment (TME) plays an essential role in HCC development metastasis, leading to poor prognosis. The overall TME immune cells infiltration characterizations mediated by immune-related genes (IRGs) remain unclear. In this study, we aimed investigate whether could be indicators for prognosis patients cell characterization as well responses immunotherapy....
Colorectal cancer stem cells (CCSCs) play important roles in the prognosis, chemoresistance, and treatment failure of colorectal (CRC). Ferroptosis is an effective for CCSCs. Vitamin D (VD) reportedly inhibits colon cell proliferation. However, information on relationship between VD ferroptosis CCSCs not well documented. In this study, we aimed to understand effect To end, treated with different concentrations performed spheroid formation assay transmission electron microscopy determined...
Abstract Aerobic glycolysis metabolic reprogramming is one of the most important hallmarks malignant tumors. Increasing evidence indicates that long non‐coding RNAs (lncRNAs) are able to regulate and promote cancer progression by functioning as competing endogenous RNAs. lncARSR a newly identified onco‐lncRNA in renal cancer, but its potential role metastatic colorectal (CRC) remains unclear. Here, we analyzed specimens from 89 patients with CRC demonstrated was highly expressed tissues...
Catalpol is an effective active ingredient that functions as a diuretic and laxative, exhibits blood sugar-lowering, liver protective, anti-aging anticancer effects. In traditional Chinese medicine, catalpol believed to be Yin nourishing. The effect of on human HCT116 colorectal cancer cells were investigated the mechanism action was evaluated. Cellular viability detected using MTT assay. Caspase-3 caspase-9 activity, cellular apoptosis nucleic morphology analyzed caspase-3 activity assay...
The current study aimed to investigate the relationship between severity of gastroesophageal reflux disease (GERD) according Los Angeles (LA) classification and esophageal motility using high-resolution manometry (HRM) 24-hour pH monitoring.We examined 124 patients with GERD from January 2016 June 2018. LA each patient was determined by endoscopy. HRM performed intraluminal water infusion method. monitoring parameters were studied statistically compared.On examination, symptoms found be...
Colorectal cancer (CRC) is the second most lethal malignancy around world. Limited efficacy of immunotherapy creates an urgent need for development novel treatment targets. Secretogranin II (SCG2) a member chromogranin family acidic secretory proteins, has role in tumor microenvironment (TME) lung adenocarcinoma and bladder cancer. Besides, SCG2 stroma-related gene CRC, its potential function regulating immune infiltration CRC needs to be fully elucidated. In this study, we used western...
Therapeutic cancer vaccines offer the greatest advantage of enhancing antigen-specific immunity against tumors, particularly for immunogenic such as melanoma. However, clinical responses remain unsatisfactory, primarily due to inadequate T cell priming and development acquired immune tolerance. A major obstacle lies in inefficient uptake antigen by peripheral dendritic cells (DCs) their migration lymph nodes presentation. In this context, magnetic delivery antigen-loaded liposomes (Ag-MLs)...
The Guanylate binding proteins (GBPs) are a family of large GTPases and the most studied GBP member is guanylate protein 1 (GBP1). Earlier studies revealed that GBP1 expression was inflammatory cytokines-inducible, focused on inflammation diseases. Increasing number cancer began to reveal its biological role in cancers recently, although with contradictory findings literature. It discovered from our earlier prostate cell line models when cells treated either ethidium bromide or cycle...
Aims The flipped classroom (FC) is a hybrid approach, combining online learning and face-to-face activities. To comprehensively evaluate the role of Flipped Classroom model in clinical skills teaching medical interns investigate acceptance recognition FC Objective Structured Clinical Examinations (OSCE).Methods In skills, students were further grouped into two groups- A B (A = 37, 42), using computer-based random digital method. group adopted traditional (TC) model, model. OSCE was used to...
BACKGROUND:The effects of Helicobacter pylori (H. pylori) infection on gastroesophageal reflux disease (GERD) remain unclear. The aim this study was to compare the results clinical esophageal function tests and effect H. GERD. MATERIAL AND METHODS:A prospective included 124 patients diagnosed with GERD (four grades). determined by gastroscopy a rapid urease test (RUT) divide into an HP-positive HP-negative group. Esophageal high-resolution manometry (HRM), peristalsis break (PB), 24-hour pH...
A 59-year-old woman with back pain underwent an F-NaF PET/CT bone scan. Unexpectedly, multiple foci of increased tracer uptake were present in the abdomen and pelvis, which corresponded to calcified soft tissue masses. The subsequent F-FDG not only confirmed FDG activity these partially mass but also revealed abnormal noncalcified lesions. pathological examination demonstrated that patient had ovarian cancer.
Ferroptosis is a promising colorectal cancer (CRC) treatment strategy; however, its value in prognosis remains at an exploratory stage. Little research has been conducted on vitamin D and ferroptosis, although shown to inhibit CRC through various mechanisms. A retrospective study was using RNA-seq profiles corresponding clinical information of patients retrieved from TCGA GEO databases.We used R package process analyze the data. We established prognostic signature with elastic network...
Increasing evidence indicates that the hepatitis B virus (HBV) replicates in peripheral blood mononuclear cells (PBMCs), but at a low level. The present study aimed to establish reliable and sensitive method effectively detects HBV viral products for monitoring antiviral therapy, organ transplantation screening, diagnosing occult infection. In study, PBMCs (obtained from six healthy volunteers) were inoculated with HBV, cultured phytohemagglutinin (PHA) interleukin‑2 (IL‑2) stimulate cell...
Background and aim: Accurate differentiation of patients with ulcerative colitis (UC) or Crohn's disease (CD) is important for appropriate therapy prognosis. This study was designed to explore the utility proteinase 3 anti-neutrophil cytoplasmic antibodies (PR3-ANCA) in diagnosis Chinese inflammatory bowel (IBD).Methods: Blood samples were collected from 216 patients, including 175 IBD 41 colorectal polyps (disease control). Clinical characteristics extracted electronic medical...
Studies have shown that ferroptosis, an iron-dependent regulated cell death, is related to prognosis and chemotherapy, but the role of ferroptosis in pancreatic adenocarcinoma (PAAD) still unclear. We aimed at constructing a ferroptosis-related gene (FRGs) model predict PAAD patients' overall survival (OS) exploring their values chemotherapy. downloaded mRNA-sequencing data corresponding clinical patients with from The Cancer Genome Atlas. Lasso-penalized Cox regression analysis was utilized...