A5055077686- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- Cancer Mechanisms and Therapy
- Circular RNAs in diseases
- Endometriosis Research and Treatment
- Ovarian cancer diagnosis and treatment
- T-cell and B-cell Immunology
- FOXO transcription factor regulation
- Cell death mechanisms and regulation
- Erythrocyte Function and Pathophysiology
- Cancer-related gene regulation
- Reproductive System and Pregnancy
- Robotics and Automated Systems
- Nuclear Receptors and Signaling
- Genetics and Neurodevelopmental Disorders
- Single-cell and spatial transcriptomics
- PARP inhibition in cancer therapy
- Autism Spectrum Disorder Research
- Bioinformatics and Genomic Networks
- Immunodeficiency and Autoimmune Disorders
Hunan University
2025
Dongguan People’s Hospital
2024
Shanghai Liangyou (China)
2024
Zhongnan Hospital of Wuhan University
2020-2023
Wuhan University
2020-2023
Hubei Provincial Center for Disease Control and Prevention
2020-2022
Guangdong Medical College
2021
Resistance to chemotherapy is a major challenge for the treatment of patients with colorectal cancer (CRC). Previous studies have found that microRNAs (miRNAs) play key roles in drug resistance; however, role miRNA-373-3p (miR-375-3p) CRC remains unclear. The current study aimed explore potential function miR-375-3p 5-fluorouracil (5-FU) resistance. MicroRNA-375-3p was be widely downregulated human cell lines and tissues promote sensitivity cells 5-FU by inducing colon apoptosis cycle arrest...
Adaptive immunity, mediated by T and B cell responses, is essential for defending against infections cancers while also being implicated in autoimmune diseases. Tracking repertoires situ at single-cell resolution understanding adaptive immune responses. To address the lack of tools T/BCR (XCR) sequencing, we developed Stereo-XCR-seq, an efficient strategy retrieving sequencing TCR BCR from Stereo-seq cDNA libraries subcellular resolution. Stereo-XCR-seq provides unbiased full-length XCR...
Colorectal cancer (CRC) is the second most lethal malignancy around world. Limited efficacy of immunotherapy creates an urgent need for development novel treatment targets. Secretogranin II (SCG2) a member chromogranin family acidic secretory proteins, has role in tumor microenvironment (TME) lung adenocarcinoma and bladder cancer. Besides, SCG2 stroma-related gene CRC, its potential function regulating immune infiltration CRC needs to be fully elucidated. In this study, we used western...
Colorectal cancer (CRC) is one of the most common carcinomas and fourth leading cause cancer-related death worldwide. One obstacles in successful treatment CRC a high rate recurrence. We aimed to construct weighted gene co-expression network analysis (WGCNA) identify key modules hub genes association with recurrence patients. firstly used microarray data, GSE41258, modules. Furthermore, protein interaction (PPI) was also performed screen genes. To validate genes, an independent dataset...
Peroxisomes are pivotal metabolic organelles that exist in almost all eukaryote cells. A reduction numbers and enzymatic activities of peroxisomes was found colon adenocarcinomas. However, the role or peroxisome pathway colorectal cancer (CRC) is not defined.In current study, a score calculated to indicate activity using gene set variant analysis based on transcriptomic datasets. CIBERSORTx chosen infer enriched immune cells for tumors among subgroups. The SubMap algorithm applied predict...
Nuclear casein kinase and cyclin-dependent substrate 1 (nucks1) are considered a potential susceptibility gene for certain neurological diseases, such as Parkinson’s disease (PD). In our study, we genotyped three single nucleotide polymorphisms (SNPs) (rs4951261, rs823114 rs951366) of the nucks1 in 774 schizophrenic patients 819 healthy controls using improved multiplex ligation detection reaction (imLDR) technique. Furthermore, also studied relationship between above SNPs clinical...
Abstract Ovarian endometrioma (OE) is a common gynecological condition characterized by the formation of “chocolate cysts”. Recent research indicates that cyst fluid acts as “toxic environment” for ovary and plays significant role in development OE, with macrophages being pivotal. However, specific molecular cellular mechanisms it are not fully understood. In this study, clinical samples integrated, single‐cell sequencing, vivo vitro experimental models to comprehensively investigate effects...