A5087588356- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Extracellular vesicles in disease
- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Membrane Separation Technologies
- Covalent Organic Framework Applications
- Electromagnetic Launch and Propulsion Technology
- Nuclear Receptors and Signaling
- Genetics and Neurodevelopmental Disorders
- Advanced Technologies and Applied Computing
- E-commerce and Technology Innovations
- Cancer Cells and Metastasis
- Membrane-based Ion Separation Techniques
- Metastasis and carcinoma case studies
- Sensor Technology and Measurement Systems
- Hemoglobin structure and function
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Traditional Chinese Medicine Analysis
- Membrane Separation and Gas Transport
- Sepsis Diagnosis and Treatment
Ningxia Medical University
2016-2025
Institute of Urban Environment
2024
Chinese Academy of Sciences
2024
Xi'an Jiaotong University
2021-2024
Ningxia Medical University General Hospital
2020-2023
Foshan Maternity and Child Health Care Hospital
2021
Guangdong Medical College
2021
Abstract Incorporating hydrophilic and charged porous nanofillers to prepare high-performance thin film nanocomposite (TFN) nanofiltration (NF) membranes is an effective method achieve efficient water treatment. In this study, we synthesize the sulfonated covalent organic framework nanosheets (S-CONs) with higher hydrophilicity electronegativity by immobilizing sulfonic acid groups (–SO 3 H) on TpPa-1 nanosheets. The S-CONs are incorporated in PA layer interfacial polymerization (IP)...
Accumulating evidence has shown the important roles of long non-coding RNAs (lncRNAs) in acute lung injury (ALI). This study aimed to investigate potential role lncRNA small nucleolar RNA host gene 14 (SNHG14) lipopolysaccharides (LPS)-induced ALI. Expression SNHG14, microRNA-34c-3p (miR-34c-3p) and Wnt1 inducible signaling pathway protein 1 (WISP1) LPS-exposed mouse alveolar macrophages (MH-S) tissues from mice with LPS-induced ALI was determined by reverse transcription quantitative...
The pathogenesis of Chronic Obstructive Pulmonary Disease (COPD) is implicated in airway inflammation, oxidative stress, protease/anti-protease and emphysema. Abnormally expressed non-coding RNAs (ncRNAs) play a vital role regulation COPD occurrence progression. regulatory mechanisms the circRNA/lncRNA-miRNA-mRNA (competing endogenous RNA, ceRNA) networks might facilitate our cognition RNA interactions COPD. This study aimed to identified novel transcripts constructed potential ceRNA...
BACKGROUND:Sepsis-induced lung injury is associated with high mortality. The present investigation evaluated the protective effect of hesperidin against sepsis-induced and also postulates possible mechanism its action. MATERIAL AND METHODS:Lung was induced by sepsis in all animals, which produced cecal ligation puncture (CLP). Animals were treated 10 20 mg/kg i.v. 30 min after surgery. Oxygenation index score determined levels pro-inflammatory mediators markers oxidative stress estimated...
Although chronic inflammation, oxidative stress, airway remodeling, and protease-antiprotease imbalance have been implicated in obstructive pulmonary disease (COPD), the exact pathogenesis is still obscure. Gene transcription post-transcriptional regulation taken into account as key regulators of COPD occurrence development. Identifying hub genes constructing biological regulatory networks at level will help extend current knowledge on develop potential drugs.All lung tissues from...
Abstract Background To explore the role of family with sequence similarity 13 member A (FAM13A) in TGF-β1-induced EMT small airway epithelium patients chronic obstructive pulmonary disease (COPD). Methods Small wall thickness and protein levels remodeling markers, TGF-β1, FAM13A were measured lung tissue samples from COPD non-COPD patients. The correlations expression severity marker evaluated. Gain- loss-of-function assays performed to functions cell proliferation, motility, alterations...
Lipopolysaccharide (LPS) induces myocardial dysfunction by damaging the mitochondrial structure in cardiomyocytes. Since low levels of carbon monoxide can confer cytoprotective effects against end-organ damage from endotoxic shock, we tested whether treatment with monoxide-releasing molecule-2 (CORM-2) could ameliorate LPS-induced rats maintaining dynamic equilibrium between fusion and fission processes. Cardiac function, histopathology, enzymes, changes function fusion-fission protein...
Nuclear casein kinase and cyclin-dependent substrate 1 (nucks1) are considered a potential susceptibility gene for certain neurological diseases, such as Parkinson’s disease (PD). In our study, we genotyped three single nucleotide polymorphisms (SNPs) (rs4951261, rs823114 rs951366) of the nucks1 in 774 schizophrenic patients 819 healthy controls using improved multiplex ligation detection reaction (imLDR) technique. Furthermore, also studied relationship between above SNPs clinical...
Objective: To investigate the phenomenon of small airway epithelial-mesenchymal transition (EMT) in patients with normal pulmonary function and chronic obstructive disease (COPD) who received surgical treatment for lung tumors. Methods: In this study, 52 undergoing tumors admitted to General Hospital Ningxia Medical University were included from January 2018 2019. According preoperative smoking history, divided into group A (non-smoking group, 15 patients), B (smoking 21 C (COPD stable phase...
Objective: To explore the relationship between family with sequence similarity 13 member A (FAM13A) gene and small airway remodeling in chronic obstructive pulmonary disease (COPD), effect of interference FAM13A expression on apoptosis proliferation phenotype human epithelial cells (16HBE). Methods: From January 2018 to 2020, 74 patients Department Thoracic Surgery General Hospital Ningxia Medical University were treated by surgery for lung tumors or bullae. According function smoking...
Objective To investigate the effects of traditional Chinese medicine colquhounia root tablet on expression tight junction protein claudin-2 and ZO-1 in bronchial epithelium tissues rats with acute lung injury (ALI), to study mechanism protective effect ALI. Methods Twenty-four healthy male Sprague-Dawley (SD) were randomly divided into control group, ALI group pretreatment 8 each group. The model was reproduced by intravenous injection oleic acid 0.04 mL/kg, given same amount normal...
Covalent organic frameworks (COFs) nanosheets (CONs) possess ordered permanent microchannels and excellent water stability, which make them attractive active fillers for the preparation of thin-film nanocomposite (TFN) nanofiltration (NF) membranes. Herein, we report fabrication TFN membranes by incorporating covalent framework TpPa-1 CONs as an filler in phase during interfacial polymerization (IP) reaction. The addition promotes formation extra channels (pores cavities) PA layer, rendering...
Background. Bedside electroencephalography (EEG) can monitor the changes in brain function critical patients. Light sedation is recommended intensive care unit (ICU) patients, but might confuse EEG readings. There are few studies on of severe patients with dexmedetomidine. This study aimed to explore characteristics before and after dexmedetomidine ICU. Methods. prospective enrolled sepsis who needed light sedation, we sedated was recorded for at least 60 min using a quantitative (qEEG)...