A5100707547- Advanced biosensing and bioanalysis techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- RNA Research and Splicing
- RNA modifications and cancer
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Glioma Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Biosensors and Analytical Detection
- Circular RNAs in diseases
- Dermatologic Treatments and Research
- Advanced Nanomaterials in Catalysis
- Adrenal and Paraganglionic Tumors
- Viral Infectious Diseases and Gene Expression in Insects
- Biochemical Analysis and Sensing Techniques
- IL-33, ST2, and ILC Pathways
- Single-cell and spatial transcriptomics
- Fetal and Pediatric Neurological Disorders
- Plant and Biological Electrophysiology Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
Yangzhou University
2014-2025
Hubei Provincial Center for Disease Control and Prevention
2023-2024
Zhongnan Hospital of Wuhan University
2023-2024
Wuhan University
2023-2024
Chongqing Medical University
2024
Tianjin Medical University
2022-2023
Tianjin University
2022-2023
Soochow University
2023
First Affiliated Hospital of Soochow University
2023
Northern Jiangsu People's Hospital
2019-2020
Abstract Background Stroke is the leading cause of disability worldwide, resulting in severe damage to central nervous system and disrupting neurological functions. There no effective therapy for promoting recovery. Growing evidence suggests that composition exosomes from different microenvironments may benefit stroke. Therefore, it reasonable assume secreted response infarction microenvironment could have further therapeutic effects. Methods In our study, cerebral infarct tissue extracts...
To study the expression of D2R, MGMT and VEGF for clinical significance in pituitary adenomas, to predict potential curative medical therapy dopamine agonists, temozolomide bevacizumab on adenomas. Immunohistochemistry western blot were performed detect adenoma tissue samples. The ratio high or different subtypes PA was compared by use chi-squared tests. relationships between assessed Spearman rank correlation test. association their parameters analyzed using a test, Fisher's exact...
Aneurysmal subarachnoid hemorrhage (SAH) is a severe cerebrovascular disease with very poor prognosis. The aim of the present study was to evaluate protective effects atorvastatin on early brain injury (EBI) after SAH using perforation model. Male Sprague-Dawley rats were randomly divided into four groups: sham group, group (model group), + 10 mg.kg
Variations in the intracellular expression level of cancer-related microRNAs (miRNAs) are connected with worsening tumor progression. A simple, accurate, and sensitive analytical method for imaging detection miRNA is still a great challenge due to low abundance miRNAs complexity environments. In this work, target (miRNA)-mediated catalytic hairpin assembly (CHA)-induced gold nanocage (GNC)-hairpin DNA1 (hpDNA1)-hpDNA2-GNC nanostructures were designed surface-enhanced Raman scattering (SERS)...
Purpose: Circulating tumor DNA (ctDNA) is more representative and accurate than biopsy also conducive to dynamic monitoring, facilitating diagnosis prognosis of glioma. Therefore, the present study aimed establish validate a novel amplified method for detection IDH1 R132H BRAF V600E, which were associated with genetic Patients Methods: A dual-signal amplification based on magnetic aggregation catalytic hairpin assembly (CHA) was constructed simultaneous ctDNAs. When target ctDNAs are...
Immune cell interactions and metabolic changes are crucial in determining the tumor microenvironment affecting various clinical outcomes. However, significance of metabolism evolution immune colorectal cancer (CRC) remains unexplored.
Circulating tumor DNA (ctDNA) has recently emerged as an ideal target for biomarker analytes. Thus, the development of rapid and ultrasensitive ctDNA detection methods is essential. In this study, a high-throughput surface-enhanced Raman scattering (SERS)-based lateral flow assay (LFA) strip proposed. The aim method to achieve accurate quantification TP53 PIK3CA E545K, two types ctDNAs associated with head neck squamous cell carcinoma (HNSCC), particularly point-of-care testing (POCT)....
Schematic diagram of HCR amplification strategy for the detection miRNAs. (A) The preparation process AuNHs array. (B) Synthesis SERS probes (C) and miR-31 miR-21.
The highly sensitive and reliable detection, imaging, monitoring of changes intracellular caspase-3 are critical for understanding the cell apoptosis studying progression caspase-3-related cervical cancer.
Telomerase has been considered as a biomarker for early diagnosis and prognosis assessment of hepatocellular carcinoma (HCC), while the highly sensitive specific methods remain challenging. To detect telomerase, novel surface-enhanced Raman scattering (SERS) biosensor was constructed using dual DNA-catalyzed amplification strategy composed strand displacement (SDA) catalytic hairpin assembly (CHA). This relies on extension reaction telomerase primer induced by forming long-stranded DNAs with...
Detecting microRNA (miRNA) biomarkers expression is of great significance for the diagnosis and treatment lung cancer. Surface-enhanced Raman scattering (SERS) has achieved sensing primary liver cancers. In this work, we developed a SERS technology rapid detection cancers-related miRNA (miR-196a) using bimetallic Au-Ag nanowire (AgNW@AuNPs) substrates coupled with target hairpin DNA. The finite-difference time-domain simulation proved that large number “hot spots” were generated between AgNW...
Abstract Frog egg-like bodies (FELBs), novel somatic embryogenesis (SE) structures first observed in Solanum nigrum , were induced Rorippa indica . NaCl-mediated salt and mannitol-mimicked drought stresses FELBs R which is very different from the induction by plant growth regulators (PGRs) under low light condition that was used S FELB induction. It demonstrated NaCl or mannitol supplements alone could induce but with rates, while synergy of significantly increased rates. For combination 5.0...
Monitoring ferroptosis-related miRNAs is crucial for the treatment and prognosis of patients with intracerebral hemorrhage. In this work, a novel hydrophobic paper (h-paper)-based plasmonic substrate was produced by dropping DS Au nanorods narrow range sizes morphologies onto h-paper. Raman reporter molecules were adsorbed to array surface, surface-enhanced scattering spectra at randomly selected points reveal uniform significant SERS enhancement. Hairpin DNAs labelled reporters hybridized...
To study the expression of D2R, MGMT and VEGF for clinical significance in pituitary adenomas, to predict potential curative medical therapy dopamine agonists, temozolomide bevacizumab on adenomas. Immunohistochemistry western blot were performed detect adenoma tissue samples. The ratio high or different subtypes PA was compared by use chi-squared tests. relationships between assessed Spearman rank correlation test. association their parameters analyzed using a test, Fisher's exact...
ABSTRACT: The expansion/shrinkage of oilwell cement is one the key factors affecting cementing quality and safe operation oil gas wells. Accurate measurement crucial for ensuring integrity. Existing devices can measure shrinkage accurately but fail to capture expansion. Therefore, this paper introduces a novel evaluation apparatus, which converts expansion into radial stress, enabling effective Experimental studies on containing MgO agents have validated effectiveness device. results...
Abstract Background: Maintaining lipid homeostasis to prevent lipotoxicity is crucial for various tumors, including colorectal cancer (CRC). Hu-antigen R (HuR) a member of the RNA binding protein family and overexpressed in many types, which implicted that regulating cell proleferation, migration, invasion, metabolism. However, role HuR abnormal metabolism CRC unknown. Methods: Western blot was performed screen differentially expressed between tissues adjacent normal tissues. Lipidomic...
Abstract Maintaining a balanced lipid status to prevent lipotoxicity is of paramount importance in various tumors, including colorectal cancer (CRC). HuR, an RNA-binding protein family member, exhibits high expression many cancers possibly because it regulates cell proliferation, migration, invasion, and metabolism. However, the role HuR regulation abnormal metabolism CRC remains unknown. We found that promotes vitamin D receptor (VDR) ensure homeostasis by increasing triglyceride (TG) total...
Without intervention, the natural wound healing process can often result in scarring, which have detrimental effects on both physical and mental well-being of patients. Therefore, it is crucial to develop biomaterials that promote without scarring. Regulating Yes-associated protein-1/PDZ-binding motif (YAP/TAZ) signaling pathway possible reduce excessive fibrosis fibroblasts proliferation vascular endothelial cells, ultimately impacting scar formation. Arsenic trioxide (ATO), an ancient drug...