A5053303048- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- RNA Research and Splicing
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Polyamine Metabolism and Applications
- Cancer Research and Treatments
- Diabetes and associated disorders
- Diabetes Management and Research
- Cancer, Lipids, and Metabolism
- Pancreatic function and diabetes
- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Cancer, Hypoxia, and Metabolism
- Antioxidant Activity and Oxidative Stress
- Axon Guidance and Neuronal Signaling
- FOXO transcription factor regulation
- Colorectal Cancer Treatments and Studies
- Ion Channels and Receptors
- RNA regulation and disease
- Endoplasmic Reticulum Stress and Disease
- PI3K/AKT/mTOR signaling in cancer
- Genomics, phytochemicals, and oxidative stress
Yanbian University Hospital
2013-2025
First Affiliated Hospital of Henan University
2024
West China Second University Hospital of Sichuan University
2024
Tibet University
2024
Sichuan University
2024
Scholar Rock (United States)
2023
Wuhan University
2020-2022
Zhongnan Hospital of Wuhan University
2020-2022
Kunming Medical University
2021
Third Xiangya Hospital
2021
Significance Aberrant microRNA (miRNA) expression is involved in tumorigenesis, and miR-224 was observed to be up-regulated certain tumor types. However, the role of pathogenesis lung cancer remains poorly understood. Here, we comprehensively analyzed revealed mechanisms up-regulation its oncogenic nonsmall cell (NSCLC). We showed that promotes cellular migratory, invasive, proliferative capacity growth both vitro vivo. Furthermore, identified TNFα-induced protein 1 SMAD4 as targets . In...
Resistance to chemotherapy is a major challenge for the treatment of patients with colorectal cancer (CRC). Previous studies have found that microRNAs (miRNAs) play key roles in drug resistance; however, role miRNA-373-3p (miR-375-3p) CRC remains unclear. The current study aimed explore potential function miR-375-3p 5-fluorouracil (5-FU) resistance. MicroRNA-375-3p was be widely downregulated human cell lines and tissues promote sensitivity cells 5-FU by inducing colon apoptosis cycle arrest...
Occludin is a transmembrane tight junction (TJ) protein that plays an important role in TJ assembly and regulation of the epithelial barrier function, but mechanisms underlying its post-transcriptional are unknown. The RNA-binding HuR modulates stability translation many target mRNAs. Here, we investigated occludin expression therefore intestinal function. bound 3'-untranslated region mRNA enhanced translation. association with depended on Chk2-dependent phosphorylation. Reduced...
Malignant melanoma (MM) is a highly aggressive subtype of skin cancer characterized by poor prognosis, particularly in the advanced stages. Despite advancements targeted therapy and immunotherapy, survival rates for MM remain low, underscoring need new therapeutic targets. Pleckstrin homology domain‑containing family A member 4 (PLEKHA4), which has regulatory functions pivotal cellular processes, emerged as potential target melanoma. The present study aimed to investigate role PLEKHA4...
One of the remarkable metabolic characteristics cancer cells is that they prefer glycolysis rather than oxidative phosphorylation (OXPHOS). Pyruvate dehydrogenase E1 alpha subunit (PDHA1) an important prerequisite for OXPHOS. Our previous studies have shown low level PDHA1 protein expression in esophageal squamous cell (ESCC) was correlated with poor prognosis. However, effect inhibition on metabolism and biological behavior remains unclear.In this study, a KYSE450 knockout (KO) line...
Eph receptor 2 (EphA2) overexpression is frequently accompanied by the loss of its cognate ligand during tumor progression. However, molecular mechanism this ligand-independent promotion EphA2 remains unclear in highly malignant and fatal cholangiocarcinoma (CC). We examined biological role growth metastasis CC tissues cells according to degree differentiation we explored downstream signaling pathways EphA2. Growth factor-mediated itself leads activation mammalian target rapamycin complex 1...
Defects in intestinal epithelial integrity occur commonly various pathologies. miR-222 is implicated many aspects of cellular function and plays an important role several diseases, but its exact biological the epithelium underexplored. We generated mice with tissue-specific overexpression to investigate physiology diseases vivo. Transgenic expression inhibited mucosal growth increased susceptibility apoptosis small intestine, thus leading atrophy. The miR-222-elevated was vulnerable...
Peroxisomes are pivotal metabolic organelles that exist in almost all eukaryote cells. A reduction numbers and enzymatic activities of peroxisomes was found colon adenocarcinomas. However, the role or peroxisome pathway colorectal cancer (CRC) is not defined.In current study, a score calculated to indicate activity using gene set variant analysis based on transcriptomic datasets. CIBERSORTx chosen infer enriched immune cells for tumors among subgroups. The SubMap algorithm applied predict...
Transient receptor potential canonical-1 (TRPC1) functions as a store-operated Ca 2+ channel in intestinal epithelial cells (IECs), and induced TRPC1 expression sensitizes IECs to apoptosis by inhibiting NF-κB activation. However, the exact mechanism which increased results inactivation remains elusive. Protein phosphatase 2A (PP2A) is widely conserved protein serine/threonine that implicated regulation of wide array cellular including apoptosis. The present study tests hypothesis inhibits...
Recent studies have demonstrated that the overexpression of H19 may contribute towards development tumorigenesis in various types cancer. To investigate role non‑small cell lung cancer (NSCLC), 76 NSCLC tissues samples and their adjacent normal tissue were collected. Expression level H19, its association with clinicopathological features overall survival was analyzed. It found compared tissues, expression elevated along a decreased miR‑203 level. also patients who advanced clinical stages...
Cardiac hypertrophy is caused by cardiac volume or pressure overload conditions and ultimately leads to contractile dysfunction heart failure. Oxytocin (OT), an endocrine nonapeptide, has been identified as a cardiovascular homeostatic hormone with anti-hypertrophic effects. However, the underlying mechanism remains elusive. In this study, we aimed investigate role of OT in hypertrophy. The rats induced isoproterenol (ISO) were treated without oxytocin. functional parameters analyzed...
Due to the high morbidity and poor clinical outcomes, early predictive prognostic biomarker identification is desiderated in colorectal cancer (CRC). As a homologue of Deleted Colorectal Cancer (DCC) gene, role Neogenin-1 (NEO1) CRC remained unveiled. This study was designed probe into effects potential function NEO1 CRC.Online databases, Gene Set Enrichment Analysis (GSEA), quantitative real-time PCR western blotting were used evaluate expression tissues. Survival analysis performed predict...
Radiotherapy is one of the main therapies for colorectal cancer, but radioresistance often leads to radiotherapy failure. To improve radioresistance, we explore effect oligomycin A, H
<h3>Background</h3> Transforming growth factor-beta (TGFβ), specifically the TGFβ1 isoform, drives tumor immune escape by promoting an immunosuppressive pro-tumor microenvironment, including reducing antigen presentation, as well impairing T-cell infiltration and tumor-killing activity. SRK-181 is a fully human, selective, IgG4 monoclonal antibody targeting latent under investigation monotherapy or in combination with anti-PD-(L)1 therapy to overcome resistance checkpoint inhibition....