A5016784148- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- DNA Repair Mechanisms
- Circular RNAs in diseases
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Genetic Neurodegenerative Diseases
- Microtubule and mitosis dynamics
- Lung Cancer Treatments and Mutations
- interferon and immune responses
- Cell death mechanisms and regulation
- Genomics, phytochemicals, and oxidative stress
- Machine Learning in Bioinformatics
- RNA and protein synthesis mechanisms
- Cancer Genomics and Diagnostics
- Glycosylation and Glycoproteins Research
- Sperm and Testicular Function
- Genomics and Phylogenetic Studies
- Extracellular vesicles in disease
- Carcinogens and Genotoxicity Assessment
- BRCA gene mutations in cancer
- Signaling Pathways in Disease
- Glutathione Transferases and Polymorphisms
- Lichen and fungal ecology
Sungkyunkwan University
2020-2025
The Ohio State University
2011-2022
Stanford University
2017-2020
Stanford Cancer Institute
2020
Stratford University
2020
Seoul National University
1994-2019
Cancer Genetics (United States)
2018
The Ohio State University Wexner Medical Center
2014
Ohio University
2012
Institut Pasteur
2012
p53 suppresses tumor progression and metastasis. Epithelial–mesenchymal transition (EMT) is a key process in The transcription factors ZEB1 ZEB2 promote EMT. Here, we show that EMT by repressing expression of ZEB2. By profiling 92 primary hepatocellular carcinomas (HCCs) 9 HCC cell lines, found up-regulates microRNAs (miRNAs), including miR-200 miR-192 family members. members transactivated then repress ZEB1/2 expression. p53-regulated also Inhibition or overexpression the miRNAs affects...
The mechanism by which the 8q24 MYC enhancer region, including cancer-associated variant rs6983267, increases cancer risk is unknown due to lack of protein-coding genes at 8q24.21. Here we report identification long noncoding RNAs named region (CARLos) in region. expression one RNAs, CARLo-5, significantly correlated with rs6983267 allele associated increased susceptibility. We also found physically interacts active regulatory CARLo-5 promoter, suggesting long-range interaction promoter...
MicroRNAs (miRNAs) are small 19- to 24-nt noncoding RNAs that have the capacity regulate fundamental biological processes essential for cancer initiation and progression. In cancer, miRNAs may function as oncogenes or tumor suppressors. Here, we conducted global profiling in a cohort of stage 1 nonsmall cell lung cancers ( n = 81) determined miR-486 was most down-regulated miRNA tumors compared with adjacent uninvolved tissues, suggesting loss be important development. We report directly...
MicroRNAs (miRNAs) are increasingly implicated in regulating cancer initiation and progression. In this study, two miRNAs, miR-25 -32, identified as p53-repressed miRNAs by p53-dependent negative regulation of their transcriptional regulators, E2F1 MYC. However, -32 result p53 accumulation directly targeting Mdm2 TSC1, which regulators the mTOR (mammalian target rapamycin) pathway, respectively, leading to inhibition cellular proliferation through cell cycle arrest. Thus, there is a...
The functions of long noncoding RNAs (lncRNAs) have been identified in several cancers, but the roles lncRNAs colorectal cancer (CRC) are less well understood. transcription factor MYC is known to regulate and has implicated cell proliferation tumorigenesis.CRC cells tissues were profiled identify differentially expressed CRC, from which we further selected MYC-regulated lncRNAs. We used luciferase promoter assay, ChIP, RNA pull-down deletion mapping LC-MS/MS immunoprecipitation determine...
Significance Aberrant microRNA (miRNA) expression is involved in tumorigenesis, and miR-224 was observed to be up-regulated certain tumor types. However, the role of pathogenesis lung cancer remains poorly understood. Here, we comprehensively analyzed revealed mechanisms up-regulation its oncogenic nonsmall cell (NSCLC). We showed that promotes cellular migratory, invasive, proliferative capacity growth both vitro vivo. Furthermore, identified TNFα-induced protein 1 SMAD4 as targets . In...
Highlights•ERK phosphorylation followed by Pin1-mediated isomerization impairs XPO5 activity•Downregulation of miR-122 leads to taxol resistance through septin-9 and MARK4•XPO5 correlates with poor prognosis in HCC patients•Pin1 MARK4 are potential targets for clinical intervention liver cancerSummaryMicroRNAs (miRNA) mostly downregulated cancer. However, the mechanism underlying this phenomenon precise consequence tumorigenesis remain obscure. Here we show that ERK suppresses pre-miRNA...
Tumor genotyping is not routinely performed in localized non-small cell lung cancer (NSCLC) due to lack of associations mutations with outcome. Here, we analyze 232 consecutive patients NSCLC and demonstrate that KEAP1 NFE2L2 are predictive high rates local recurrence (LR) after radiotherapy but surgery. Half LRs occurred tumors KEAP1/NFE2L2 mutations, indicating they major molecular drivers clinical radioresistance. Next, functionally evaluate our cohort only pathogenic associated...
Lung cancer is the leading cause of mortality in world today. Although some advances lung therapy have been made, patient survival still poor. MicroRNAs (miRNAs) can act as oncogenes or tumor-suppressor genes human malignancy. The miR-34 family consists tumor-suppressive miRNAs, and its reduced expression has reported various cancers, including non-small cell (NSCLC). In this study, we found that miR-34a miR-34c target platelet-derived growth factor receptor alpha beta (PDGFR-α PDGFR-β),...
Anticancer peptides are emerging anticancer drug that offers fewer side effects and is more effective than chemotherapy targeted therapy. Predicting from sequence information one of the most challenging tasks in immunoinformatics. In past ten years, machine learning-based approaches have been proposed for identifying ACP activity peptide sequences. These methods include our previous method MLACP (developed 2017) which made a significant impact on research. tool has widely used by research...
Long noncoding RNAs (lncRNAs) are primarily regulated by their cellular localization, which is responsible for molecular functions, including cell cycle regulation and genome rearrangements. Accurately identifying the subcellular location of lncRNAs from sequence information crucial a better understanding biological functions mechanisms. In contrast to traditional experimental methods, bioinformatics or computational methods can be applied annotation lncRNA locations in humans more...
RNA N4-acetylcytidine (ac4C) is a highly conserved modification that plays crucial role in controlling mRNA stability, processing, and translation. Consequently, accurate identification of ac4C sites across the genome critical for understanding gene expression regulation mechanisms. In this study, we have developed ac4C-AFL, bioinformatics tool precisely identifies from primary sequences. identified optimal sequence length model building implemented an adaptive feature representation...
Nonsmall cell lung cancer (NSCLC) is one of the leading causes death worldwide. TNF-related apoptosis-inducing ligand (TRAIL) has been shown to induce apoptosis in malignant cells without inducing significant toxicity normal cells. However, several carcinomas, including cancer, remain resistant TRAIL. MicroRNAs (miRNAs) are small noncoding RNAs ∼ 24 nt that block mRNA translation and/or negatively regulate its stability. They often aberrantly expressed and have implicated increasing...
Significance TRAIL (TNF-related apoptosis-inducing ligand) is a promising antitumor agent effective in very small subset of lung cancer patients with low toxicity. However, the majority tumors are TRAIL-resistant and little known about how tumor cells acquire resistance to TRAIL. Here, we show that continuous exposure subtoxic concentrations induces NF-κB–dependent up-regulation miR-21, miR-30c, miR-100, which by silencing caspase-8, caspase-3, TRAF7, FoxO3a further strengthens NF-κB...
// Ri Cui 1,4,* , Taewan Kim 2,* Matteo Fassan 1,3 Wei Meng 5 Hui-Lung Sun 1 Young-Jun Jeon Caterina Vicentini 6 Esmerina Tili 1,7 Yong Peng 8 Aldo Scarpa 9 Guang Liang 10 Kui Zhang 11 Arnab Chakravarti and Carlo M. Croce Department of Molecular Virology, Immunology Medical Genetics Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA 2 Cellular Oncology, University Texas MD Anderson Houston, TX, 3 Medicine (DIMED), Padua, Italy 4 Chemical Biology Research School...
Abstract The worldwide appearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has generated significant concern and posed a considerable challenge to global health. Phosphorylation is common post-translational modification that affects many vital cellular functions closely associated with SARS-CoV-2 infection. Precise identification phosphorylation sites could provide more in-depth insight into the processes underlying infection help alleviate continuing COVID-19 crisis....
// Taewan Kim 1, * , Ri Cui 2, Young-Jun Jeon 2 Paolo Fadda Hansjuerg Alder Carlo M. Croce 1 Department of Molecular and Cellular Oncology, The University Texas MD Anderson Cancer Center, Houston, TX, USA Virology, Immunology Medical Genetics, Comprehensive Ohio State University, Columbus, OH, These authors have contributed equally to this work Correspondence to: Croce, e-mail: carlo.croce@osumc.edu Keywords: MYC, long noncoding RNA, cell proliferation, cycle Received: April 09, 2015...
Abstract Oncogenic KRAS induces tumor onset and development by modulating gene expression via different molecular mechanisms. MicroRNAs (miRNAs) are small non-coding RNAs that have been established as main players in tumorigenesis. By overexpressing wild type or mutant (KRAS G12D ) using inducible human mouse cell lines, we analyzed KRAS-regulated microRNAs non-small-cell lung cancer (NSCLC). We show miR-30c miR-21 significantly upregulated both isoforms induce drug resistance enhance...