A5102952340- Cellular Automata and Applications
- RNA modifications and cancer
- DNA and Biological Computing
- RNA Research and Splicing
- Cancer-related gene regulation
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Computability, Logic, AI Algorithms
- Algorithms and Data Compression
- Evolutionary Algorithms and Applications
- Coding theory and cryptography
- semigroups and automata theory
- Cancer-related molecular mechanisms research
- Theoretical and Computational Physics
- MicroRNA in disease regulation
- Mathematical Dynamics and Fractals
- Lung Cancer Research Studies
- Advanced Data Storage Technologies
- Genomics and Chromatin Dynamics
- Cancer-related Molecular Pathways
- Gene Regulatory Network Analysis
- Chaos control and synchronization
- Modular Robots and Swarm Intelligence
- Pancreatic and Hepatic Oncology Research
- Quantum-Dot Cellular Automata
Cancer Research UK Manchester Institute
2016-2024
University of Manchester
2017-2024
Institute of Physics, Bhubaneshwar
2013-2024
Aarhus University Hospital
2012-2016
Utkal University
2015
Queen's University Belfast
2006-2011
Indian Statistical Institute
2009
Highlights•Inhibitors of LSD1 target both scaffolding and enzymatic functions the protein•GFI1/CoREST complex is targeted for disruption release from chromatin•GFI1/CoREST required leukemia cell differentiation•Loss enhancer-bound GFI1/LSD1 activates nearby myeloid differentiation genesSummaryPharmacologic inhibition promotes blast in acute (AML) with MLL translocations. The assumption has been that induced through blockade LSD1's histone demethylase activity. However, we observed rapid,...
Inflammation can support or restrain cancer progression and the response to therapy. Here, we searched for primary regulators of cancer-inhibitory inflammation through deep profiling inflammatory tumor microenvironments (TMEs) linked immune-dependent control in mice. We found that early intratumoral accumulation interferon gamma (IFN-γ)-producing natural killer (NK) cells induced a profound remodeling TME unleashed cytotoxic T cell (CTL)-mediated eradication. Mechanistically, tumor-derived...
Abstract Lung cancer is the leading cause of cancer-related deaths worldwide. KRAS main oncogenic driver in lung that can be activated by gene mutation or amplification, but whether long non-coding RNAs (lncRNAs) regulate its activation remains unknown. Through gain and loss function approaches, we identified lncRNA HIF1A-As2 , a KRAS-induced lncRNA, required for cell proliferation, epithelial-mesenchymal transition (EMT) tumor propagation non-small (NSCLC) vitro vivo. Integrative analysis...
SCLC accounts for approximately 250,000 deaths worldwide each year. Acquisition of adequate tumor biopsy samples is challenging, and liquid biopsies present an alternative option patient stratification response monitoring.
In NSCLC alterations in PDGF receptors are markers of worst prognosis and efficient targeting these is yet to be achieved. this study, we explored PDGFR-regulated microRNAs demonstrating that miR-23b cluster miR-125a-5p downregulated by increased expression PDGFR-α or PDGFR-β cells. Mechanistically, the positively regulated p53 negatively modulated NF-kB p65. Forced enhanced drug sensitivity suppressed invasiveness cells silencing several genes involved oncogenic KRAS pathways, including...
Abstract Oncogenic KRAS induces tumor onset and development by modulating gene expression via different molecular mechanisms. MicroRNAs (miRNAs) are small non-coding RNAs that have been established as main players in tumorigenesis. By overexpressing wild type or mutant (KRAS G12D ) using inducible human mouse cell lines, we analyzed KRAS-regulated microRNAs non-small-cell lung cancer (NSCLC). We show miR-30c miR-21 significantly upregulated both isoforms induce drug resistance enhance...
Abstract Serial biopsy of pancreatic ductal adenocarcinoma (PDAC), to chart tumour evolution presents a significant challenge. We examined the utility circulating free DNA (cfDNA) as minimally invasive approach across cohort 55 treatment-naïve patients with PDAC; 31 metastatic and 24 locally advanced disease. Somatic mutations in cfDNA were detected using next generation sequencing 15/24 (62.5%) 27/31 (87%) disease, respectively. Copy number changes 10 whom 7 exhibited gain chromosome 12p...
Abstract Wild-type KRAS ( WT ) amplification has been shown to be a secondary means of activation in cancer and associated with poor survival. Nevertheless, the precise role overexpression lung progression is largely unexplored. Here, we identify characterize KRAS-responsive lncRNA, KIMAT1 (ENSG00000228709) show that it correlates levels both cell lines specimens. Mechanistically, MYC target drives tumorigenesis by promoting processing oncogenic microRNAs (miRNAs) through DHX9 NPM1...
Precision dosing strategies require accounting for between-patient variability in pharmacokinetics (PK), affecting drug exposure, and pharmacodynamics (PD), response achieved at the same concentration site of action. Although liquid biopsy assessing different levels molecular targets has yet to be established, individual characterization elimination pathways using recently been demonstrated. The feasibility applying this approach conjunction with modeling tools guide remains unexplored. In...
Chronic myelomonocytic leukaemia (CMML) is a haematological malignancy characterized by overlapping myeloid dysplasia and proliferation with persisting monocytosis. While monocytes are the cardinal malignant cell type in CMML, as stem neoplasm disease clone comprises most lineages differentiation stages, including granulocytes. To investigate pathogenic contribution of granulocytes CMML maintenance progression, we performed phenotypic, transcriptomic functional characterization Compared...
Abstract Chromosomal instability (CIN) is a driver of clonal diversification and intratumor heterogeneity, providing genetic diversity that contributes to tumor progression. It estimated approximately 80% solid cancers, including non–small cell lung cancer (NSCLC), exhibit features CIN, which affects growth response therapy. However, the molecular mechanisms connecting CIN progression are still poorly understood. Through an RNAi screen performed on genes involved in overexpressed human...
This paper presents hardware architecture to perform the basic arithmetic operation addition using cellular automata (CA). age old problem of were previously solved by ripple circuit or carry look ahead a combination them. Each these circuits is purely combinational in nature and their complexity centered on number logic gates associated gate delays. On contrary, our CA based design mainly clock cycles required finish computation instead
This paper deals with the theory and application of 2-Dimensional, nine-neighborhood, null- boundary, uniform as well hybrid Cellular Automata (2D CA) linear rules in image processing. These are classified into nine groups depending upon number neighboring cells influences cell under consideration. All Uniform have been found to be rendering multiple copies a given on which they belong where Hybrid also shown characterizing phenomena zooming in, out, thickening thinning image. Further, using...
A subset of lung adenocarcinomas is driven by the EML4-ALK translocation. Even though ALK inhibitors in clinic lead to excellent initial responses, acquired resistance these due on-target mutations or parallel pathway alterations a major clinical challenge. Exploring mechanisms resistance, we found that cells parental resistant crizotinib, ceritinib alectinib are remarkably sensitive inhibition CDK7/12 with THZ1 and CDK9 alvocidib dinaciclib. These compounds robustly induce apoptosis through...
Hypoxia and a suppressive tumour microenvironment (TME) are both independent negative prognostic factors for muscle-invasive bladder cancer (MIBC) that contribute to treatment resistance. has been shown induce an immune TME by recruiting myeloid cells inhibit anti-tumour T cell responses. Recent transcriptomic analyses show hypoxia increases signalling infiltrates in cancer. This study sought investigate the relationship between hypoxia-inducible factor (HIF)-1 -2, hypoxia, MIBC. ChIP-seq...
In this paper we have defined two functions that been used to construct different fractals having fractal dimensions between 1 and 2. More precisely, can say one of our produce the whose dimension lies in [1.58, 2) rest function (1, 1.58]. Also tried calculate amount increment accordance with base number systems. And switching from another, is constant, which 1.58, its quite surprising!
Recently, new RNA secondary structure probing techniques have been developed, including Next Generation Sequencing based methods capable of transcriptome-wide. These hold great promise for improving prediction accuracy. However, each data type comes with its own signal properties and biases, which may even be experiment specific. There is therefore a growing need that can automatically trained on types readily extended to integrate fully exploit multiple data.Here, we develop explore modular...
Precision medicine aims to tailor cancer therapies target specific tumor-promoting aberrations. For tumors that lack actionable drivers, which occurs frequently in the clinic, extensive molecular characterization and pre-clinical drug efficacy studies will be required. A cell line maintained at low passage a patient- derived xenograft model (PDX) were generated using fresh biopsy from patient with poorly-differentiated neuroendocrine tumor of unknown primary origin. Next-generation...
In this paper the theory of Carry Value Transformation (CVT) is designed and developed on a pair n-bit strings used to produce many interesting patterns. One them found be self-similar fractal whose dimension same as Sierpinski triangle. Different construction procedures like L-system, Cellular Automata rule, Tilling for are obtained which signifies that other tools CVT can also formation fractals. It shown production periodic well chaotic Also, analytical algebraic properties discussed. The...
The present paper on classification of -variable Boolean functions highlights the process in a coherent way such that each class contains single affine function. Two unique and different methods have been devised for this classification. first one is recursive procedure uses Cartesian product sets starting from set variable functions. In second method, done by changing some predefined bit positions with respect to function belonging class. which are also provide us information concerning...
This paper addresses all possible equivalence classes of 1-variable Boolean functions and from these using recursion Cartesian product sets, 15 different ways classifications n-variable are obtained. The properties with regard to the size number for also elaborated.