A5103006530- SARS-CoV-2 and COVID-19 Research
- Cellular Automata and Applications
- Animal Virus Infections Studies
- DNA and Biological Computing
- Machine Learning in Bioinformatics
- RNA and protein synthesis mechanisms
- Fractal and DNA sequence analysis
- Bacteriophages and microbial interactions
- Gene Regulatory Network Analysis
- Biochemical Analysis and Sensing Techniques
- Algorithms and Data Compression
- Evolutionary Algorithms and Applications
- Coding theory and cryptography
- Computability, Logic, AI Algorithms
- Advanced Chemical Sensor Technologies
- Bioinformatics and Genomic Networks
- Viral gastroenteritis research and epidemiology
- Olfactory and Sensory Function Studies
- COVID-19 Clinical Research Studies
- Protein Structure and Dynamics
- Mathematical Dynamics and Fractals
- Genomics and Phylogenetic Studies
- Respiratory viral infections research
- SARS-CoV-2 detection and testing
- Theoretical and Computational Physics
Indian Statistical Institute
2014-2023
University of Calcutta
2021-2022
Johns Hopkins Medicine
2020
Johns Hopkins University
2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of pandemic disease 2019 (COVID-19) that exhibits an overwhelming contagious capacity over other human coronaviruses (HCoVs). This structural snapshot describes bases underlying SARS-CoV-2 and explains its fast motion epithelia allow rapid cellular entry. Based on notable viral spike (S) protein features, we propose flat sialic acid-binding domain at N-terminal (NTD) S1 subunit leads to more effective first...
There is a consensus that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated naturally from bat coronaviruses (CoVs), in particular RaTG13. However, the SARS-CoV-2 host tropism/adaptation pattern has significant discrepancies compared with other CoVs, raising questions concerning proximal origin of SARS-CoV-2. The flat and nonsunken surface sialic acid-binding domain spike protein (S protein) conflicts general adaptation survival observed for all CoVs. Unlike RaTG13,...
Immune evasion is one of the unique characteristics severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) attributed to its ORF8 protein. This protein modulates adaptive host immunity through down-regulation MHC-1 (Major Histocompatibility Complex) molecules and innate immune responses by surpassing host's interferon-mediated antiviral response. To understand perspective in reference protein, a comprehensive study mutations possessed it have been performed. Chemical structural...
The origin of the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) virus causing COVID-19 pandemic has not yet been fully determined. Despite consensus about SARS-CoV-2 from bat CoV RaTG13, discrepancy to host tropism other human Coronaviruses exist. also possesses some differences in its S protein receptor-binding domain, glycan-binding N-terminal domain and surface sialic acid-binding domain. similarities based on cryo-EM biochemical studies, shows higher stability binding...
Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) that engendering severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to three sub-domains viz. amino acids (aa) 22–42, aa 79–84, and 330–393 ACE2 on human cells initiate entry. It was reported earlier utilization capacity proteins from different species, such as cats, chimpanzees, dogs, cattle,...
Comparison of amino acid sequence similarity is the fundamental concept behind protein phylogenetic tree formation. By virtue this method, we can explain evolutionary relationships, but further explanations are not possible unless sequences studied through chemical nature individual acids. Here develop a new methodology to characterize on basis We design various algorithms for studying variation group transitions and combinations as patterns in sequences. The conventional myosin II head...
A molecular evolutionary analysis of a well conserved protein helps to determine the essential amino acids in core catalytic region. Based on chemical properties acid residues, phylogenetic total 172 homologous sequences highly enzyme, L-myo-inositol 1-phosphate synthase or MIPS from evolutionarily diverse organisms was performed. This study revealed presence six phylogenetically blocks, out which four embrace functional protein. Further, specific modifications targeting lysine known be...
Intricate comparison between two given tertiary structures of proteins is as important the their functions. In literature, several algorithms have been devised to compute similarity and dissimilarity among protein structures. But, these compare by structural alignment backbones which are usually unable determine precise differences. this paper, an attempt has made similarities dissimilarities using fundamental mathematical morphology operations fractal geometry can decipher intricate doing...
Open reading frame 8 (ORF8) shows one of the highest levels variability among accessory proteins in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), causative agent Disease 2019 (COVID-19). It was previously reported that ORF8 protein inhibits presentation viral antigens by major histocompatibility complex class I (MHC-I), which interacts with host factors involved pulmonary inflammation. The assists SARS-CoV-2 evading immunity and plays a role replication. Among many...
This paper presents hardware architecture to perform the basic arithmetic operation addition using cellular automata (CA). age old problem of were previously solved by ripple circuit or carry look ahead a combination them. Each these circuits is purely combinational in nature and their complexity centered on number logic gates associated gate delays. On contrary, our CA based design mainly clock cycles required finish computation instead
This paper deals with the theory and application of 2-Dimensional, nine-neighborhood, null- boundary, uniform as well hybrid Cellular Automata (2D CA) linear rules in image processing. These are classified into nine groups depending upon number neighboring cells influences cell under consideration. All Uniform have been found to be rendering multiple copies a given on which they belong where Hybrid also shown characterizing phenomena zooming in, out, thickening thinning image. Further, using...