A5005630434- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Immune cells in cancer
- Asthma and respiratory diseases
- Macrophage Migration Inhibitory Factor
- Phagocytosis and Immune Regulation
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
Stanford University
2022-2023
Centre for Inflammation Research
2018-2020
University of Manchester
2018-2020
Hull York Medical School
2016
University of York
2016
Inflammation can support or restrain cancer progression and the response to therapy. Here, we searched for primary regulators of cancer-inhibitory inflammation through deep profiling inflammatory tumor microenvironments (TMEs) linked immune-dependent control in mice. We found that early intratumoral accumulation interferon gamma (IFN-γ)-producing natural killer (NK) cells induced a profound remodeling TME unleashed cytotoxic T cell (CTL)-mediated eradication. Mechanistically, tumor-derived...
Abstract Cross-talk between NK cells and dendritic (DCs) is important in Th1 immune responses, including antitumor immunity responses to infections. DCs also play a crucial role polarizing Th2 immunity, but the impact of cell–DC interactions this context remains unknown. In study, we stimulated human monocyte-derived vitro with different pathogen-associated molecules: LPS or polyinosinic–polycytidylic acid, which polarize response, soluble egg Ag from helminth worm Schistosoma mansoni,...
<div>Abstract<p>γδ T cells stimulated by phosphoantigens (pAg) are potent effectors that secrete Th1 cytokines and kill tumor cells. Consequently, they considered candidates for use in cancer immunotherapy. However, have proven only moderately effective several clinical trials. We studied the consequences of pAg-stimulated γδ T-cell interactions with natural killer (NK) CD8<sup>+</sup> cells, major innate adaptive effectors, respectively. found suppressed NK-cell...
Supplementary Figure from Phosphoantigen-Stimulated γδ T Cells Suppress Natural Killer–Cell Responses to Missing-Self
<div>Abstract<p>γδ T cells stimulated by phosphoantigens (pAg) are potent effectors that secrete Th1 cytokines and kill tumor cells. Consequently, they considered candidates for use in cancer immunotherapy. However, have proven only moderately effective several clinical trials. We studied the consequences of pAg-stimulated γδ T-cell interactions with natural killer (NK) CD8<sup>+</sup> cells, major innate adaptive effectors, respectively. found suppressed NK-cell...
Supplementary Figure from Phosphoantigen-Stimulated γδ T Cells Suppress Natural Killer–Cell Responses to Missing-Self