A5015245629- Insect and Pesticide Research
- Plant and animal studies
- Insect and Arachnid Ecology and Behavior
- Colorectal Cancer Treatments and Studies
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Genetic Associations and Epidemiology
- Hepatocellular Carcinoma Treatment and Prognosis
- Health Systems, Economic Evaluations, Quality of Life
- Nuclear Receptors and Signaling
- Zoonotic diseases and public health
- Bacterial Identification and Susceptibility Testing
- Cancer, Hypoxia, and Metabolism
- Cardiac Imaging and Diagnostics
- Synthesis of Tetrazole Derivatives
- Frailty in Older Adults
- Lymphoma Diagnosis and Treatment
- Bone health and treatments
- Cardiovascular Function and Risk Factors
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- Macrophage Migration Inhibitory Factor
- RNA Interference and Gene Delivery
- Neuroendocrine Tumor Research Advances
Bayer (United Kingdom)
2025
Cancer Research UK Manchester Institute
2019-2021
CRUK Lung Cancer Centre of Excellence
2021
Cancer Research UK
2020-2021
University of Manchester
2019-2021
Sciensano (Belgium)
2018-2019
Institut Scientifique de Santé Publique
2017-2018
Ghent University
2015-2017
•A total of 870 patients admitted with COVID-19 were enrolled in nine countries.•LV size and function analyzed by a core lab AI.•LV RV dysfunction are common acute illness portend poor prognosis.•Age, lung disease, LDH, LVLS, RVFWS associated in-hospital mortality.•World regional LV/RV differences highlight patient acuity echo utilization. BackgroundThe novel severe respiratory syndrome coronavirus-2 virus, which has led to the global coronavirus disease-2019 (COVID-19) pandemic is known...
SCLC accounts for approximately 250,000 deaths worldwide each year. Acquisition of adequate tumor biopsy samples is challenging, and liquid biopsies present an alternative option patient stratification response monitoring.
Abstract Serial biopsy of pancreatic ductal adenocarcinoma (PDAC), to chart tumour evolution presents a significant challenge. We examined the utility circulating free DNA (cfDNA) as minimally invasive approach across cohort 55 treatment-naïve patients with PDAC; 31 metastatic and 24 locally advanced disease. Somatic mutations in cfDNA were detected using next generation sequencing 15/24 (62.5%) 27/31 (87%) disease, respectively. Copy number changes 10 whom 7 exhibited gain chromosome 12p...
Abstract Small cell lung cancer (SCLC) has a 5-year survival rate of <7%. Rapid emergence acquired resistance to standard platinum-etoposide chemotherapy is common and improved therapies are required for this recalcitrant tumour. We exploit six paired pre-treatment post-chemotherapy circulating tumour patient-derived explant (CDX) models from donors with extensive stage SCLC investigate changes at disease progression after chemotherapy. Soluble guanylate cyclase (sGC) recurrently...
Stress echocardiography (SE) is one of the most commonly used diagnostic imaging tests for coronary artery disease (CAD) but requires clinicians to visually assess scans identify patients who may benefit from invasive investigation and treatment. EchoGo Pro provides an automated interpretation SE based on artificial intelligence (AI) image analysis. In reader studies, use when making clinical decisions improves accuracy confidence. Prospective evaluation in real world practice now important...
Abstract Purpose There has been increased difficulty in developing safe and effective treatment using PI3K inhibitors heme malignancies, despite the role of PI3K/AKT being well defined this population. This study was an attempt to conduct exploratory biomarker analysis retrospectively from phase III CHRONOS-3 trial with aim identify a sub-set patients that could benefit treatment. Patients Methods CD20-positive indolent B-cell lymphoma were randomized 2:1 receive intravenous copanlisib plus...
Circulating tumour cells (CTCs) are a marker of poor prognosis and associated with increased risk venous thromboembolism in metastatic breast cancer (MBC). We aimed to determine if the presence CTCs plasma markers hypercoagulability [thrombin–antithrombin III (TAT), fibrinogen d-dimer] biomarkers survival MBC. In prospective study MBC patients, CTC (CellSearch®) enumeration TAT, d-dimer measured prior commencement treatment for disease progression were correlated overall survival. At...
Small-cell lung cancer (SCLC), an aggressive neuroendocrine malignancy, has limited treatment options beyond platinum-based chemotherapy, whereafter acquired resistance is rapid and common. By analyzing expression data from SCLC tumors, patient-derived models, established cell lines, we show that the of TIAM1, activator small GTPase RAC1, associated with a gene program. TIAM1 depletion or RAC1 inhibition reduces viability tumorigenicity cells by increasing apoptosis conversion BCL2 its...
BackgroundUse of artificial intelligence (AI) in cardiovascular imaging may potentially augment clinical decision-making disease management, but no prospective randomized controlled trials have assessed the impact on outcomes. This study evaluates whether AI–augmented is non-inferior to standard when selecting participants for invasive coronary angiography following stress echocardiography.MethodsPROTEUS was a multicenter, parallel-group trial. We enrolled undergoing echocardiogram at 20...
Summary American Foulbrood, caused by Paenibacillus larvae , is the most severe bacterial disease of honey bees ( Apis mellifera ). To perform genotyping P. in an epidemiological context, there a need fast and cheap method with high resolution. Here, we propose Multiple Locus Variable number tandem repeat Analysis MLVA has been used for typing collection 209 strains from which 23 different types could be identified. Moreover, developed methodology not only permits identification four...
Loss of skeletal muscle (SM) and gain subcutaneous fat (SCF) are known side-effects androgen-deprivation in treatment prostate cancer. Scarce data is available concerning the effects abiraterone/pred (ABI) on body composition no published regarding enzalutamide (ENZA). Our objective was to analyse ENZA SM/SCF compare results with ABI patients metastatic castration-resistant prostate-cancer (mCRPC). 54 starting (n = 17) or 37) at a single-centre between 2012 2018 were retrospectively...
National and international efforts like the 1000 Genomes Project are leading to increasing insights in genetic structure of populations worldwide. Variation between different necessitates access population-based reference datasets. These data, which important not only clinical settings but also potentiate future transitions towards a more personalized public health approach, currently available for Belgian population. To obtain representative dataset population, participants 2013 Health...
American foulbrood, caused by the Gram-positive bacteria Paenibacillus larvae, is one of most severe bacterial diseases European honey bee. The bacterium has been known for long, but only last decade mechanisms used pathogen to cause disease in its host are starting unravel. In this study, knowledge virulent behaviour expanded and several possible virulence factors suggested.Identification done random mutagenesis ensure an unbiased approach. A library mutants was tested a significant...
Paenibacillus larvae is a highly contagious and often lethal widely distributed pathogen of honeybees, Apis mellifera but has not been reported in eastern Africa to date. We investigated the presence P. western highland agro-ecological zones Uganda by collecting brood honey samples from 67 honeybee colonies two sampling occasions cultivated them for larvae. Also, 8 honeys imported locally retailed were sampled Our aim was establish distribution populations determine if that contained this...
Abstract Introduction: The PI3K inhibitor copanlisib (C) plus the anti-CD20 antibody rituximab (R) was superior to R placebo (P) in patients (pts) with relapsed iNHL (Matasar et al. Lancet Oncol 2021). We previously reported that C+R improved median progression-free survival (PFS) iNHL, follicular lymphoma (FL), and non-FL groups, a statistically significant improvement PTEN-positive population (Shalini al., AACR 2022). Here we conducted NGS analysis from pts treated either or P+R for...
older patients represent the majority of cancer but are under-represented in trials, particularly early phase clinical trials (EPCTs).observational retrospective study referred for EPCTs (January-December 2018) at a specialist centre UK. The primary aim was to analyse successful enrolment into according age (<65/65+). secondary aims were identify obstacles and outcomes enrolled patients. Patient data analysed at: referral; in-clinic assessment after enrolment. Among assessed clinic, sample...
Abstract Background Patients with metastatic colorectal cancer are treated cytotoxic chemotherapy supplemented by molecularly targeted therapies. There is a critical need to define biomarkers that can optimise the use of these therapies maximise efficacy and avoid unnecessary toxicity. However, it important first changes in potential following alone. This study reports impact standard across range circulating imaging biomarkers. Methods A single-centre, prospective, biomarker-driven study....