A5100753495- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- RNA modifications and cancer
- Ovarian cancer diagnosis and treatment
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Cancer Mechanisms and Therapy
- Hepatocellular Carcinoma Treatment and Prognosis
- COVID-19 and healthcare impacts
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- Listeria monocytogenes in Food Safety
- Marine Bivalve and Aquaculture Studies
- Microbial Inactivation Methods
- Circular RNAs in diseases
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- CAR-T cell therapy research
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Genetic Syndromes and Imprinting
Institute of Oceanology
2019-2025
Chinese Academy of Sciences
2019-2025
China National Center for Food Safety Risk Assessment
2025
Nanjing Agricultural University
2020-2025
Qingdao National Laboratory for Marine Science and Technology
2019-2025
University of Manchester
2014-2024
Huazhong Agricultural University
2021-2023
CRUK Lung Cancer Centre of Excellence
2021-2023
Cancer Research UK
2020-2023
Cancer Research UK Manchester Institute
2013-2023
Purpose Circulating tumor cells (CTCs) may have utility as surrogate biomarkers and “virtual” biopsies. We report the clinical significance molecular characteristics of CTCs CTC clusters, termed circulating microemboli (CTM), detected in patients with small-cell lung cancer (SCLC) undergoing standard treatment. Patients Methods Serial blood samples from 97 receiving chemotherapy were analyzed using EpCam-based immunomagnetic detection a filtration-based technique. Proliferation status (Ki67)...
Abstract Background With the advent of immunotherapy, substantial progress has been made in improving outcomes for patients with advanced cancer. However, not all benefit equally from treatment, and confounding immune-related issues may have an impact. Several studies suggest that antibiotic use (which alters gut microbiome) result poorer treated immune checkpoint inhibitors (ICI). Materials Methods This is a large, single-site retrospective review n = 291 cancer ICI (n 179 melanoma, 64...
Tumor recurrence after surgical resection of NSCLC obstructs long-term disease-free survival in approximately 50% cases. Our data suggest that combining circulating tumor cell enumeration (as single cells or clusters) tumor-draining pulmonary vein and peripheral blood (assessed by CellSearch) at the time surgery better identifies those patients higher risk for lung cancer than does number alone.
Randomized ovarian cancer trials, including ICON7, have reported improved progression-free survival (PFS) when bevacizumab was added to conventional cytotoxic therapy. The improvement modest prompting the search for predictive biomarkers bevacizumab.
SCLC accounts for approximately 250,000 deaths worldwide each year. Acquisition of adequate tumor biopsy samples is challenging, and liquid biopsies present an alternative option patient stratification response monitoring.
A mass spectrometry-based plasma biomarker discovery workflow was developed to facilitate discovery. Plasma from either healthy volunteers or patients with pancreatic cancer 8-plex iTRAQ labeled, fractionated by 2-dimensional reversed phase chromatography and subjected MALDI ToF/ToF spectrometry. Data were processed using a q-value based statistical approach maximize protein quantification identification. Technical (between duplicate samples) biological variance within individuals)...
Abstract Oncological use of anti-angiogenic VEGF inhibitors has been limited by the lack informative biomarkers. Previously we reported circulating Tie2 as a vascular response biomarker for bevacizumab-treated ovarian cancer patients. Using advanced MRI and biomarkers have extended these findings in metastatic colorectal ( n = 70). Bevacizumab (10 mg/kg) was administered to elicit response, followed FOLFOX6-bevacizumab until disease progression. induced correlation between tumor imaging...
Abstract Serial biopsy of pancreatic ductal adenocarcinoma (PDAC), to chart tumour evolution presents a significant challenge. We examined the utility circulating free DNA (cfDNA) as minimally invasive approach across cohort 55 treatment-naïve patients with PDAC; 31 metastatic and 24 locally advanced disease. Somatic mutations in cfDNA were detected using next generation sequencing 15/24 (62.5%) 27/31 (87%) disease, respectively. Copy number changes 10 whom 7 exhibited gain chromosome 12p...
Research on probiotics assisting PD-1 inhibitors in anti-tumor therapy has attracted widespread attention. Therefore, it is important to find new probiotic strains with a inhibitor promoting effect. This study aims strain good effect treatment from 5 the function of modulating gut microbiota or enhancing immunity. A preclinical combined murine melanoma was designed. In this study, Lactobacillus kefiranofaciens ZW18 (ZW18) found have best anti-melanoma among candidates treatment. inhibited...
Vasculogenic mimicry (VM), the process of tumor cell transdifferentiation to endow endothelial-like characteristics supporting de novo vessel formation, is associated with poor prognosis in several types, including SCLC. In genetically engineered mouse models (GEMMs) SCLC, NOTCH, and MYC co-operate drive a neuroendocrine (NE) non-NE phenotypic switch, co-operation between NE cells required for metastasis. Here, we define phenotype VM-competent molecular mechanisms underpinning SCLC VM using...
Gastrointestinal cancer is a prevalent disease with high morbidity and mortality. Tissue factor pathway inhibitor 2 (TFPI2) gene could protect the extracellular matrix of cells from degradation tumor invasion. The goal our study was to estimate diagnostic value TFPI2 hypermethylation in gastric (GC) colorectal (CRC). methylation measured by quantitative methylation-specific polymerase chain reaction (qMSP) method 114 GC 80 CRC tissues their paired non-tumor tissues. Our results showed that...
Background This study described clinical characteristics and outcome in systemic lupus erythematosus (SLE) patients with diffuse alveolar hemorrhage (DAH), investigated risk factors prognostic for DAH. Methods We conducted a retrospective nested case–control analysis single-center cohort. enrolled 94 SLE For each case of DAH, two age-, sex-, courses–matched controls were randomly selected from our All between 2004 2019 followed until death, end registration the physician’s practice, or...
The aim of this study was to apply high-throughput sequencing analyse the differences among three extraction methods (A—direct separation bacteria, B—the precipitation bacterial colonies at 37 °C, and C—the 6.5 °C) bacteria from chilled pork on day 0, 4 8. Results PCA Venn plot indicated that resulted in different communities. At beginning storage, group A showed higher numbers OTUs (Operational Taxonomic Units) species pork. Acinetobacter sp. Myroides were dominant storage then...
Heat shock protein 70 (HSP70) members participate in a wide range of housekeeping and stress-related activities eukaryotic cells. In marine ecosystems, bivalves encounter abiotic stresses, including high temperatures low dissolved oxygen. Here, 133 MmHSP70 genes were identified through combined methods Blastp, HMM manual filtration, based on the whole Mercenaria mercenaria genome. The unevenly distributed, 41 (33.08%) located Chr 7. Phylogenetic analyses indicated that gene family mainly...
Novel anticancer drugs targeting key apoptosis regulators have been developed and are undergoing clinical trials. Pharmacodynamic biomarkers to define the optimum dose of drug that provokes tumor in demand; acquisition longitudinal biopsies is a significant challenge minimally invasive required. Considering this, we validated preclinical 'death-switch' model for discovery secreted tumour using vitro proteomics vivo evaluation novel imaging probe [18F]ML-10 non-invasive detection positron...