Dhruva Biswas
A5048953598- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Cardiovascular Function and Risk Factors
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Cardiac Valve Diseases and Treatments
- Heart Failure Treatment and Management
- Lung Cancer Diagnosis and Treatment
- Machine Learning in Healthcare
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Cancer-related molecular mechanisms research
- Single-cell and spatial transcriptomics
- CAR-T cell therapy research
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Cancer Cells and Metastasis
- Ubiquitin and proteasome pathways
- Radiomics and Machine Learning in Medical Imaging
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
University College London
2019-2025
Cancer Research UK
2019-2025
The Francis Crick Institute
2019-2025
London Cancer
2019-2025
CRUK Lung Cancer Centre of Excellence
2019-2025
King's College London
2023-2025
Yale University
2024-2025
King's College Hospital NHS Foundation Trust
2023-2025
British Heart Foundation
2023-2024
King's College Hospital
2023-2024
Abstract Cytosolic DNA is characteristic of chromosomally unstable metastatic cancer cells, resulting in constitutive activation the cGAS–STING innate immune pathway. How tumors co-opt inflammatory signaling while evading surveillance remains unknown. Here, we show that ectonucleotidase ENPP1 promotes metastasis by selectively degrading extracellular cGAMP, an immune-stimulatory metabolite whose breakdown products include suppressor adenosine. loss suppresses metastasis, restores tumor...
Lung cancer is the leading cause of cancer-associated mortality worldwide
Abstract B cells are frequently found in the margins of solid tumours as organized follicles ectopic lymphoid organs called tertiary structures (TLS) 1,2 . Although TLS have been to correlate with improved patient survival and response immune checkpoint blockade (ICB), underlying mechanisms this association remain elusive Here we investigate lung-resident cell responses patients from TRACERx 421 (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy) other lung cancer cohorts, a...
Abstract Murine tissues harbor signature γδ T cell compartments with profound yet differential impacts on carcinogenesis. Conversely, human tissue-resident cells are less well defined. In the present study, we show that lung a resident Vδ1 population. Moreover, demonstrate memory and effector phenotypes were enriched in tumors compared nontumor tissues. Intratumoral possessed stem-like features skewed toward cytolysis helper type 1 function, akin to intratumoral natural killer CD8 +...
Abstract Checkpoint inhibition (CPI), particularly that targeting the inhibitory coreceptor programmed cell death protein 1 (PD-1), has transformed oncology. Although CPI can derepress cancer (neo)antigen-specific αβ T cells ordinarily show PD-1-dependent exhaustion, it also be efficacious against cancers evading recognition. In such settings, γδ have been implicated, but functional relevance of PD-1 expression by these is unclear. Here we demonstrate intratumoral TRDV1 transcripts (encoding...
Abstract Recognition and elimination of pathogens cancer cells depend on the adaptive immune system. Thus, accurate quantification subsets is vital for precision medicine. We present lymphocyte estimation from nucleotide sequencing (ImmuneLENS), which estimates T cell B fractions, class switching clonotype diversity whole-genome data at depths as low 5× coverage. By applying ImmuneLENS to 100,000 Genomes Project, we identify genes enriched with somatic mutations in cell-rich tumors,...
An innate-like γδ T cell compartment in healthy human breast is described and shown to correlate with remission triple-negative cancer.
Activating mutations in KRAS occur 32% of lung adenocarcinomas (LUAD). Despite leading to aggressive disease and resistance therapy preclinical studies, the mutation does not predict patient outcome or response treatment, presumably due additional events modulating RAS pathways. To obtain a broader measure pathway activation, we developed RAS84, transcriptional signature optimised capture oncogenic activity LUAD. We report evidence activation 84% LUAD, including 65% wild-type tumours,...
Heart failure with preserved ejection fraction (HFpEF) remains under-diagnosed in clinical practice despite accounting for nearly half of all heart (HF) cases. Accurate and timely diagnosis HFpEF is crucial proper patient management treatment. In this study, we explored the potential natural language processing (NLP) to improve detection according European Society Cardiology (ESC) diagnostic criteria.
Abstract Checkpoint inhibitors (CPIs) augment adaptive immunity. Systematic pan-tumor analyses may reveal the relative importance of tumour cell intrinsic and microenvironmental features underpinning CPI sensitization. Here we collated whole-exome transcriptomic data for >1000 CPI-treated patients across eight tumor-types, utilizing standardized bioinformatics-workflows clinical outcome-criteria to validate multivariate predictors CPI-sensitization. Clonal-TMB was strongest predictor...
Abstract Human tumors are diverse in their natural history and response to treatment, which part results from genetic transcriptomic heterogeneity. In clinical practice, single-site needle biopsies used sample this diversity, but cancer biomarkers may be confounded by spatiogenomic heterogeneity within individual tumors. Here we investigate clonally expressed genes as a solution the sampling bias problem analyzing multiregion whole-exome RNA sequencing data for 450 tumor regions 184 patients...
Abstract Background Aortic stenosis (AS) is a condition marked by high morbidity and mortality in severe, symptomatic cases without intervention via transcatheter aortic valve implantation (TAVI) or surgical replacement (SAVR). Racial ethnic disparities access to these treatments have been documented, particularly North America, where socioeconomic factors like health insurance confound analyses. This study evaluates AS management across racial groups, accounting for deprivation, using an...