A5058220226- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Pleural and Pulmonary Diseases
- Gastric Cancer Management and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Esophageal and GI Pathology
- Tracheal and airway disorders
- Cancer Genomics and Diagnostics
- Esophageal Cancer Research and Treatment
- COVID-19 and healthcare impacts
- Cancer Immunotherapy and Biomarkers
- Medical Imaging and Pathology Studies
- Myasthenia Gravis and Thymoma
- Pneumothorax, Barotrauma, Emphysema
- RNA modifications and cancer
- Bone Tumor Diagnosis and Treatments
- Trauma and Emergency Care Studies
- Immunotherapy and Immune Responses
- Ultrasound in Clinical Applications
- Airway Management and Intubation Techniques
- Cancer Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Head and Neck Cancer Studies
- Lung Cancer Research Studies
University of Liverpool
2014-2025
Liverpool Heart and Chest Hospital
2014-2025
University of Birmingham
2020-2022
Institut de Virologie
2020-2021
Association for Cancer Surgery
2021
NIHR Birmingham Biomedical Research Centre
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
AstraZeneca (Brazil)
2020
Stryker (United Kingdom)
2020
Video-assisted thoracoscopic surgery (VATS) lobectomy has been gradually accepted as an alternative surgical approach to open thoracotomy for selected patients with non-small-cell lung cancer (NSCLC) over the past 20 years. The aim of this project was standardize perioperative management VATS through expert consensus and provide insightful guidance clinical practice.A panel 55 experts on identified by Scientific Secretariat International Committee '20th Anniversary Lobectomy Conference-The...
Abstract Aim Lung metastases from colorectal cancer are resected in selected patients the belief that this confers a significant survival advantage. It is generally assumed 5‐year of these would be near zero without metastasectomy. We tested clinical effectiveness practice Pulmonary Metastasectomy Colorectal Cancer (PulMiCC), randomized, controlled noninferiority trial. Method Multidisciplinary teams 14 hospitals recruited with resectable lung into two‐arm Randomization was remote and...
Lung cancer is the leading cause of cancer-associated mortality worldwide
BackgroundThere is limited randomized evidence on the comparative outcomes of early-stage lung cancer resection by video-assisted thoracoscopic surgery (VATS) versus open resection.MethodsWe conducted a parallel-group multicenter trial that recruited participants with known or suspected and randomly assigned them to VATS their lesions. The primary outcome was physical function at 5 weeks as measure recovery using European Organisation for Research Treatment Cancer core health-related quality...
Abstract Murine tissues harbor signature γδ T cell compartments with profound yet differential impacts on carcinogenesis. Conversely, human tissue-resident cells are less well defined. In the present study, we show that lung a resident Vδ1 population. Moreover, demonstrate memory and effector phenotypes were enriched in tumors compared nontumor tissues. Intratumoral possessed stem-like features skewed toward cytolysis helper type 1 function, akin to intratumoral natural killer CD8 +...
Introduction Lung cancer is a leading cause of deaths worldwide and surgery remains the main treatment for early stage disease. Prior to introduction video-assisted thoracoscopic (VATS), lung resection was undertaken through an open thoracotomy. To date, evidence base supporting different surgical approaches based on non-randomised studies, small randomised trials focused mainly short-term in-hospital outcomes. Methods analysis The VIdeo assisted lobectomy versus conventional Open LobEcTomy...
Lung cancer is the leading cause of death. Surgery remains main method managing early-stage disease. Minimal-access video-assisted thoracoscopic surgery results in less tissue trauma than open surgery; however, it not known if improves patient outcomes.
Abstract The introduction of the International Association for Study Lung Cancer grading system has furthered interest in histopathological risk stratification lung adenocarcinoma. Complex morphology and high intratumoral heterogeneity present challenges to pathologists, prompting development artificial intelligence (AI) methods. Here we developed ANORAK (pyrAmid pooliNg crOss stReam Attention networK), encoding multiresolution inputs with an attention mechanism, delineate growth patterns...
Rupture of the oesophagus is a surgical emergency with significant morbidity and mortality. We present our experience in managing such patients tertiary care cardiothoracic unit.We conducted retrospective clinical review who were admitted following rupture over period 6 years (2002-2008).In unit, there 27 admissions isolated oesophagus, which 18 males nine females. The median age was 65 (range 22-87). Twenty-four (89%) presented spontaneous perforations (Boerhaave's syndrome) three (11%)...
Red cell distribution width (RDW) has been identified as an independent risk factor with regard to prognosis in patients cardiac disease. We sought investigate the association of RDW undergoing lung resections for non-small-cell cancer respect in-hospital morbidity, mortality and long-term survival.Analysis consecutive on a validated prospective thoracic surgery database was performed those potentially curative at single institution. Univariate multivariate analyses were postoperative...
Abstract Background Surgeons provide patients with information before surgery, although standards of are lacking and practice varies. The development use a ‘core set’ as baseline surgery may improve understanding. A core set is minimum to in all consultations specific procedure. This study developed for oesophageal cancer surgery. Methods Information was identified from the literature, observations clinical patient interviews. integrated create questionnaire survey. Stakeholders (patients...
To determine the optimum management of anastomotic leaks after oesophagectomy.We undertook a retrospective review 23 patients who developed leakage, out 389 undergoing oesophagectomy with gastric interposition. The presentation, diagnosis, and treatment leaks, patient outcomes are analysed.Leaks occurred from 3 to (median=7.5) days surgery. Clinical features included fever (57%), leucocytosis (52%), dysphagia (4%), coughing bile wound infection (13%), pneumothorax (35%), pleural effusion...
INTRODUCTION Prolonged air leak (PAL) is the most common complication after partial lung resection and important determinant of length hospital stay for patients post-operatively.The aim this study was to determine risk factors involved in developing leaks consequences PAL.METHODS All undergoing between January 2002 December 2007 our were studied retrospectively.Univariate analysis predict post-operative included patient demographics, smoking status, pulmonary function tests, disease...
An inverse relationship between body mass index (BMI) and the risk of lung cancer has been reported in several studies. In this study, we aimed to assess whether BMI can affect survival after resection for cancer.We reviewed patient data a 10-year period; 337 patients with ≥ 30 who underwent non-small cell were identified. This group was matched at ratio 1:1 <30 similar characteristics such as sex, age, function test, history smoking, diabetes, peripheral vascular disease, stroke, myocardial...
Abstract Introduction: Sarcomas occurring during pregnancy are rare and they present significant challenges in clinical management, to optimise, investigations treatment choices ensure both maternal foetal well-being. Case: A 32-year-old G1P0 female presented with a rapidly growing swelling her right axilla. Ultrasound-guided core needle biopsy revealed high-grade pleomorphic malignant tumour. The dilemmas weighing the risks of staging studies, contrast-enhanced scans, surgery pre-...
The incorrect insertion of a chest drain can cause serious harm or even death. All elective drains should be inserted in the 'triangle safety' line with British Thoracic Society guidelines. aim this study was to test awareness junior doctors involved inserting these Fifty were questioned. Participants asked grade their experience and mark on diagram where they felt optimum site for large pneumothorax an situation. Only 44% (n=22) indicated would insert within safe triangle. Level experience,...
Survival after resections for non-small cell lung cancer remains poor. Recurrent common. Due to the common risk factor of smoking, cardiovascular deaths occur in absence recurrent up 15% patients. Aspirin has been proven reduce mortality as a secondary prophylactic agent, but not primary agent. being COX-2 inhibitor shown chance metastasis adenocarcinoma squamous carcinoma. We sought investigate effect long-term aspirin therapy on survival post potentially curative surgery.We analysed...
8504 Background: Video assisted thoracoscopic surgery (VATS) is a popular access for lung cancer resection. However, there limited information from RCTs in-hospital to one-year clinical efficacy, safety and oncologic outcomes of minimal approach. Methods: VIOLET parallel group multi-center RCT conducted in 9 centers the United Kingdom that recruited participants with known or suspected (cT1-3, N0-1 M0) (ISRCTN13472721). Trial protocol: https://bmjopen.bmj.com/content/9/10/e029507.info....
Abstract Background The aim of this study was to investigate tracheal acid aspiration after oesophagectomy and determine whether it is influenced by nasogastric (NG) drainage. Methods Thirty-four patients undergoing were randomized one three methods NG drainage: a single-lumen tube with free drainage 4-hourly aspiration, sump-type on continuous suction drainage, or no tube. A pH probe used collect information for 48 h surgery. &lt; 5·5 considered abnormal (normal 6·8–7·2). Total time...
Using a large, prospectively collected and independently validated thoracic database, we created risk-prediction tool for in-hospital mortality with the aim of improving on accuracy Thoracoscore.A database containing lung resections was utilized, N = 2574. Logistic regression analysis bootstrapping, by use random training test set utilized. Comparisons against Thoracoscore, ESOS.01 Society Thoracic Surgeons (STS) models were performed.A logistic model identified age [odds ratio (OR) 1.1, 95%...
Occupational and environmental airborne asbestos concentrations are too low variable for lifetime exposures to be estimated reliably, building workers occupants may suffer higher exposure when in older buildings is disturbed or removed. Mesothelioma risks from current therefore not known. We interviewed measured levels lung samples 257 patients treated pneumothorax 262 with resected cancer, recruited England Wales. Average burdens British birth cohorts 1940 1992 were asbestos-exposed the...