A5083652743- Healthcare Policy and Management
- Health disparities and outcomes
- Intensive Care Unit Cognitive Disorders
- Primary Care and Health Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Geriatric Care and Nursing Homes
- Cancer Genomics and Diagnostics
- Frailty in Older Adults
- HIV/AIDS Research and Interventions
- Family and Patient Care in Intensive Care Units
- Homelessness and Social Issues
- Childhood Cancer Survivors' Quality of Life
- Sarcoma Diagnosis and Treatment
- Healthcare cost, quality, practices
- Respiratory Support and Mechanisms
- Child and Adolescent Psychosocial and Emotional Development
- Emergency and Acute Care Studies
- Patient Satisfaction in Healthcare
- Electronic Health Records Systems
- HIV, Drug Use, Sexual Risk
- Nutrition and Health in Aging
- Lung Cancer Treatments and Mutations
- Musculoskeletal pain and rehabilitation
- Clinical practice guidelines implementation
- Health Policy Implementation Science
Kwai Chung Hospital
2024-2025
University College London
2021-2024
Cancer Research UK
2021-2024
London Cancer
2023
MedStar Health
2018-2023
University of Alberta
2022-2023
Werner-Wicker-Klinik
2023
Jones College
2023
Greyston
2023
Princess Margaret Cancer Centre
2023
Abstract B cells are frequently found in the margins of solid tumours as organized follicles ectopic lymphoid organs called tertiary structures (TLS) 1,2 . Although TLS have been to correlate with improved patient survival and response immune checkpoint blockade (ICB), underlying mechanisms this association remain elusive Here we investigate lung-resident cell responses patients from TRACERx 421 (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy) other lung cancer cohorts, a...
Abstract Murine tissues harbor signature γδ T cell compartments with profound yet differential impacts on carcinogenesis. Conversely, human tissue-resident cells are less well defined. In the present study, we show that lung a resident Vδ1 population. Moreover, demonstrate memory and effector phenotypes were enriched in tumors compared nontumor tissues. Intratumoral possessed stem-like features skewed toward cytolysis helper type 1 function, akin to intratumoral natural killer CD8 +...
Objective: We sought to assess the reliability and validity of PedsQL™ 4.0 SF15, a shortened version 23-item Generic Core Scales, which is pediatric health-related quality life (HRQoL) instrument, 3.0 SF22 Asthma Module, short-form Module. Methods: The SF15 Module were administered by telephone 125 adolescents (aged 12–18) 338 parents children with asthma 2–11). Healthy (n = 451) chronically ill 422) children, matched age, respondent status, ethnicity sample, provided data for selected...
Using data from the 2006 Medical Expenditure Panel Survey and 2000 Census, authors explored whether race/ethnic disparities in health care use were associated with residential segregation. They used five measures of use: office-based physician visits, outpatient department visits to nurses physician’s assistants, other professionals, having a usual source care. For each individual, controlled for age, gender, marital status, insurance income, educational attainment, employment region,...
Objective To examine the association between residential segregation and geographic access to primary care physicians ( PCPs ) in metropolitan statistical areas MSAs ). Data Sources We combined zip code level data on from 2006 American Medical Association master file with demographic, socioeconomic, measures 2000 U.S. Census. Our sample consisted of 15,465 codes located completely or partially an MSA . Methods defined PCP shortage as those no a population ratio >3,500. Using logistic...
Abstract Background The lack of common language among interprofessional inpatient clinical teams is an important barrier to achieving mobilization. In Johns Hopkins Hospital, the Activity Measure for Post-Acute Care (AM-PAC) Inpatient Mobility Short Form (IMSF), also called “6-Clicks,” and Highest Level (JH-HLM) are part routine practice. measurement characteristics these tools when used by both nurses physical therapists communication or assessment unknown. Objective purposes this study...
Objective Functional status decline commonly accompanies hospitalization making patients vulnerable to complications. Such can be mitigated through hospital-based early mobility programs. Success in implementing patient quality improvement processes requires evaluating providers’ knowledge, attitudes, and behaviors. Design A cross-sectional, self-administered survey two different hospital settings was completed by 120 nurses physical occupational therapists (rehabilitation therapists, 38;...
To evaluate the internal consistency, validity, responsiveness, and minimal important difference of Functional Status Score for ICU, a physical function measure designed ICU.Clinimetric analysis.Five international datasets from United States, Australia, Brazil.Eight hundred nineteen ICU patients.None.Clinimetric analyses were initially conducted separately each data source time point to examine generalizability findings, with pooled performed thereafter increase power analyses. The...
Abstract The introduction of the International Association for Study Lung Cancer grading system has furthered interest in histopathological risk stratification lung adenocarcinoma. Complex morphology and high intratumoral heterogeneity present challenges to pathologists, prompting development artificial intelligence (AI) methods. Here we developed ANORAK (pyrAmid pooliNg crOss stReam Attention networK), encoding multiresolution inputs with an attention mechanism, delineate growth patterns...
To examine the measurement equivalence of items on disability across three international surveys aging. Data for persons aged 65 and older were drawn from Health Retirement Survey (HRS, n = 10,905), English Longitudinal Study Aging (ELSA, 5,437), Health, Ageing in Europe (SHARE, 13,408). Differential item functioning (DIF) was assessed using response theory (IRT) methods activities daily living (ADL) instrumental (IADL) items. HRS SHARE exhibited equivalence, but 6 11 ELSA demonstrated...
Rapid muscle wasting occurs during acute respiratory failure, resulting in weakness and functional impairments. This study examines survivors' body composition the year after distress syndrome tests associations of patient characteristics, hospital exposures, strength physical functioning with whole percent lean mass.Prospective cohort 6- 12-month follow-up.National enrolling patients from five centers.Acute survivors (n = 120).None.Lean fat mass dual energy x-ray absorptiometry. On average,...
Using nationally representative data, we examined biological, medical system, and sociodemographic factors that are associated with health-related quality of life as measured by a multidimensional index accounts for wide range child health domains.Children aged > or = 6 years (N 69,031) were drawn from the 2003/2004 National Survey Children's Health. A random 25% sample was used to create 12-item 0 100, based on conceptual framework Child Health Illness Profile. Bivariate multivariable...
Health care quality is frequently described with measures representing the overall performance of a health system. Despite growing attention to overuse resources, there little experience aggregate overuse.To identify set possible indicators that can be operationalized claims data and describe variation in these across hospital referral regions (HRRs).Using an environmental scan, we identified published descriptions overused procedures. We assessed each procedure's feasibility for measurement...
Background Middle-aged and older adults requiring skilled home healthcare (‘home health’) services following hospital discharge are at high risk of experiencing suboptimal outcomes. Information management (IM) needed to organise communicate care plans is critical ensure safety. Little known about IM during this transition. Objectives (1) Describe the current process (activity goals, subactivities, information required, sources/targets modes communication) from health providers’ perspectives...