Holly E. McKeon
A5020044189- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Autism Spectrum Disorder Research
- Total Knee Arthroplasty Outcomes
- Obesity and Health Practices
- Cancer survivorship and care
- Head and Neck Cancer Studies
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Pain Management and Opioid Use
- Digital Mental Health Interventions
- Colorectal Cancer Screening and Detection
- Esophageal Cancer Research and Treatment
- Adolescent and Pediatric Healthcare
- Delphi Technique in Research
- Bariatric Surgery and Outcomes
- Colorectal Cancer Surgical Treatments
- Diet and metabolism studies
- Clinical practice guidelines implementation
University of Bristol
2019-2024
At Bristol
2019-2022
NIHR Evaluation Trials and Studies Coordinating Centre
2019
BackgroundThere is limited randomized evidence on the comparative outcomes of early-stage lung cancer resection by video-assisted thoracoscopic surgery (VATS) versus open resection.MethodsWe conducted a parallel-group multicenter trial that recruited participants with known or suspected and randomly assigned them to VATS their lesions. The primary outcome was physical function at 5 weeks as measure recovery using European Organisation for Research Treatment Cancer core health-related quality...
Introduction Lung cancer is a leading cause of deaths worldwide and surgery remains the main treatment for early stage disease. Prior to introduction video-assisted thoracoscopic (VATS), lung resection was undertaken through an open thoracotomy. To date, evidence base supporting different surgical approaches based on non-randomised studies, small randomised trials focused mainly short-term in-hospital outcomes. Methods analysis The VIdeo assisted lobectomy versus conventional Open LobEcTomy...
Lung cancer is the leading cause of death. Surgery remains main method managing early-stage disease. Minimal-access video-assisted thoracoscopic surgery results in less tissue trauma than open surgery; however, it not known if improves patient outcomes.
The health risks of severe obesity can be reduced with metabolic and bariatric surgery, but it is uncertain which operation most effective or cost-effective. We aimed to compare Roux-en-Y gastric bypass, adjustable banding, sleeve gastrectomy in patients obesity. By-Band-Sleeve a pragmatic, multi-centre, open-label, randomised controlled trial conducted 12 hospitals the UK. Eligible participants were adults (aged ≥18 years) meeting national criteria for surgery. Initially, 2-group (Roux-en-Y...
8504 Background: Video assisted thoracoscopic surgery (VATS) is a popular access for lung cancer resection. However, there limited information from RCTs in-hospital to one-year clinical efficacy, safety and oncologic outcomes of minimal approach. Methods: VIOLET parallel group multi-center RCT conducted in 9 centers the United Kingdom that recruited participants with known or suspected (cT1-3, N0-1 M0) (ISRCTN13472721). Trial protocol: https://bmjopen.bmj.com/content/9/10/e029507.info....
Introduction Depression is three to four times more prevalent in autistic people and related reduced quality of life. There a need for empirically supported psychological interventions depression specifically adapted meet the needs adults. ADEPT-2 aims establish clinical cost-effectiveness an low-intensity intervention (guided self-help) Methods analysis A two parallel-group multicentre pragmatic randomised controlled trial investigating effectiveness GSH Participants (n=248) aged ≥18 years...
Introduction Gabapentin is an antiepileptic drug currently licensed to treat epilepsy and neuropathic pain but has been used off-label acute postoperative pain. The GAP study will compare the effectiveness, cost-effectiveness safety of gabapentin as adjunct standard multimodal analgesia versus placebo for management after major surgery. Methods analysis a multicentre, double-blind, randomised controlled trial in patients aged 18 years over, undergoing different types surgery (cardiac,...
<h3></h3> As pathological confirmation of lung cancer influences treatment selection for suspected early stage cancer, high pre-treatment tissue rates (90%) have been recommended by the National Lung Cancer Audit 2018. However, this practice prior to radical management patients with has never studied. Using prospective collection pre-defined biopsy data within multi-disciplinary teams in UK centres, we sought define and outcomes incomplete primary undergoing surgery a multi-centre clinical...