A5043213962- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Cardiac Ischemia and Reperfusion
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Ocular Surface and Contact Lens
- Glycosylation and Glycoproteins Research
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 Clinical Research Studies
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Anesthesia and Neurotoxicity Research
- Ocular Diseases and Behçet’s Syndrome
- Pain Management and Opioid Use
- melanin and skin pigmentation
- Childhood Cancer Survivors' Quality of Life
- Lung Cancer Diagnosis and Treatment
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Health Systems, Economic Evaluations, Quality of Life
- Retinal and Optic Conditions
- Enhanced Recovery After Surgery
- Atrial Fibrillation Management and Outcomes
- Lipid Membrane Structure and Behavior
- Ethics in Clinical Research
University of Bristol
2011-2024
At Bristol
2020
Bristol Eye Hospital
2012
Cardiac surgery with cardiopulmonary bypass and cardioplegic arrest is an effective treatment for coronary artery aortic valve diseases. However, the myocardium sustains reperfusion injury after ischemic arrest. Our objective was to assess benefits of supplementing cardioplegia solution general anesthetic propofol in patients undergoing either grafting (CABG) or replacement (AVR).A single-center, double-blind randomized controlled trial carried out compare supplemented (concentration 6...
Background To assess differences in platelet inhibition during ticagrelor monotherapy (TIC) or dual therapy with and aspirin (TIC+ASP) patients after percutaneous coronary intervention using a comprehensive panel of functional tests. Methods Results In single-center parallel group, open label, randomized controlled trial, 110 participants were to receive either TIC (n=55) TIC+ASP for 4 weeks. The primary outcome was the aggregation response 10 μmol/L thrombin receptor activation peptide-6...
Paediatric chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is a relatively common and disabling condition. The National Institute for Health Clinical Excellence (NICE) recommends Cognitive Behavioural Therapy (CBT) as treatment option paediatric CFS/ME because there good evidence that it effective. Despite this, most young people in the UK are unable to access local specialist CBT CFS/ME. A randomised controlled trial (RCT) showed FITNET was effective Netherlands but we do not...
To compare normothermic (35°C-36°C) versus hypothermic (28°C) cardiopulmonary bypass (CPB) in paediatric patients undergoing open heart surgery to test the hypothesis that CPB perfusion maintains functional integrity of major organ systems leading faster recovery. Two single-centre, randomised controlled trials (known as Thermic-1 and Thermic-2, respectively) were carried out effectiveness acceptability children with congenital disease surgery. In both studies, co-primary clinical outcomes...
Introduction Adalimumab is an effective treatment for autoimmune non-infectious uveitis (ANIU), but it currently only funded a minority of patients with ANIU in the UK as restricted by National Institute Health and Care Excellence guidance. Ophthalmologists believe that adalimumab may be wider range patients. The vs placebo add-on to Standard Therapy Uveitis: Tolerability, Effectiveness cost-effectiveness (ASTUTE) trial will recruit who do not meet funding criteria evaluate effectiveness...
During open heart surgery, patients are connected to a heart-lung bypass machine that pumps blood around the body ("perfusion") while is stopped. Typically cooled during this procedure ("hypothermia") and warmed normal temperature once operation has been completed. The main rationale for "whole cooling" protect organs such as brain, kidneys, lungs, from injury by reducing body's metabolic rate decreasing oxygen consumption. However, hypothermic perfusion also disadvantages can contribute...
Background: Despite improved myocardial protection strategies, cardioplegic arrest and ischemia still result in reperfusion injury. We have previously published a study describing the effects of propofol (an anesthetic agent commonly used cardiac surgery) on metabolic stress, function, injury clinically relevant animal model. concluded that cardioplegia supplementation with at concentration to human clinical setting resulted hemodynamic reduced oxidative when compared standard cardioplegia....
Introduction Gabapentin is an antiepileptic drug currently licensed to treat epilepsy and neuropathic pain but has been used off-label acute postoperative pain. The GAP study will compare the effectiveness, cost-effectiveness safety of gabapentin as adjunct standard multimodal analgesia versus placebo for management after major surgery. Methods analysis a multicentre, double-blind, randomised controlled trial in patients aged 18 years over, undergoing different types surgery (cardiac,...
Background: Concomitant administration of COVID-19 and influenza vaccines would reduce burden on healthcare systems. We assess the safety concomitant administration. Methods: Adults in receipt a single dose ChAdOx1 or BNT162b2 were enrolled at 12 UK sites randomised 1:1 to receive either age-appropriate placebo alongside second vaccine. Three weeks later group who received vaccine, vice versa. Participants followed six weeks. The three seasonal, inactivated (trivalent, MF59C adjuvanted...
Dual antiplatelet therapy (DAPT) with aspirin (ASP) and a P2Y12 blocker is currently standard care after percutaneous coronary intervention (PCI) stent insertion, aims to inhibit platelet function in order prevent thrombosis. The ticagrelor (TIC) has greater effect than the previously used members of this class, such as clopidogrel. In healthy volunteers, TIC sufficient cause strong inhibition, little additional from ASP. Omission ASP may improve safety regimes by reducing bleeding. However,...
Abstract Background In February 2021, the UK Department of Health and Social Care sought evidence on safety immunogenicity COVID-19 influenza vaccine co-administration to inform 2021/2022 policy. Co-administration could support uptake reduce healthcare appointments. ComFluCOV was a randomised controlled trial designed provide this evidence. This report outlines methods used deliver in 6 months answer an urgent public health question as part pandemic response. Methods commissioned by managed...
Abstract Background In early 2021, the Department of Health and Social Care in UK called for research on safety immunogenicity concomitant administration COVID-19 influenza vaccines. Co-administration these vaccines would facilitate uptake reduce number healthcare visits required. The ComFluCOV trial was designed to deliver necessary evidence time inform autumn (September–November) 2021 vaccination policy. This paper presents statistical methodology applied help successfully results 6...
ObjectivesIVAN and TANDEM are factorial randomised controlled trials (RCTs) of different treatment regimens for wet AMD, involving off-label use bevacizumab.Safety data being collected but, given follow-up visits every 4-8 weeks up to 3 years verbatim reporting, difficult collate.We have developed a database solution the trial minimise duplicate adverse events or without resolution dates, based on lessons learnt in IVAN trial.
Introduction Lung cancer is the most common cause of death worldwide and patients present with extensive disease. One-year survival improving but remains low (37%) despite novel systemic anti-cancer treatments forming current standard care. Although new therapies improve survival, have residual disease after treatment, little known on how best to manage it. Therefore, management varies across UK, some receiving only maintenance treatment while others receive local consolidative (LCT),...