A5006052297- Lung Cancer Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Enhanced Recovery After Surgery
- Pleural and Pulmonary Diseases
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Trauma Management and Diagnosis
- Cancer Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Anesthesia and Pain Management
- Delphi Technique in Research
- Nausea and vomiting management
- Congenital Diaphragmatic Hernia Studies
- Dysphagia Assessment and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Colorectal Cancer Treatments and Studies
- Head and Neck Cancer Studies
- Respiratory Support and Mechanisms
- Pectus Deformity Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Esophageal Cancer Research and Treatment
- Nutrition and Health in Aging
- Ion channel regulation and function
St Bartholomew's Hospital
2022-2024
Barts Health NHS Trust
2022-2024
Bristol Royal Infirmary
2011-2022
University Hospitals Bristol NHS Foundation Trust
2014-2022
University Hospitals Bristol and Weston NHS Foundation Trust
2020-2022
National Health Service
2020-2021
North Bristol NHS Trust
2020
Thoracic Surgery Foundation
2020
Royal Brompton & Harefield NHS Foundation Trust
2019
Bristol Hospital
2019
Abstract Aim Lung metastases from colorectal cancer are resected in selected patients the belief that this confers a significant survival advantage. It is generally assumed 5‐year of these would be near zero without metastasectomy. We tested clinical effectiveness practice Pulmonary Metastasectomy Colorectal Cancer (PulMiCC), randomized, controlled noninferiority trial. Method Multidisciplinary teams 14 hospitals recruited with resectable lung into two‐arm Randomization was remote and...
BackgroundThere is limited randomized evidence on the comparative outcomes of early-stage lung cancer resection by video-assisted thoracoscopic surgery (VATS) versus open resection.MethodsWe conducted a parallel-group multicenter trial that recruited participants with known or suspected and randomly assigned them to VATS their lesions. The primary outcome was physical function at 5 weeks as measure recovery using European Organisation for Research Treatment Cancer core health-related quality...
The use of prophylactic radiotherapy to prevent procedure-tract metastases (PTMs) in malignant pleural mesothelioma remains controversial, and clinical practice varies worldwide. We aimed compare with deferred (given only when a PTM developed) suitably powered trial.We did multicentre, open-label, phase 3, randomised controlled trial 22 UK hospitals patients histocytologically proven who had undergone large-bore interventions the 35 days prior recruitment. Eligible were (1:1), using...
Introduction Lung cancer is a leading cause of deaths worldwide and surgery remains the main treatment for early stage disease. Prior to introduction video-assisted thoracoscopic (VATS), lung resection was undertaken through an open thoracotomy. To date, evidence base supporting different surgical approaches based on non-randomised studies, small randomised trials focused mainly short-term in-hospital outcomes. Methods analysis The VIdeo assisted lobectomy versus conventional Open LobEcTomy...
Abstract Aim We wanted to examine survival in patients with resected colorectal cancer (CRC) whose lung metastases are or not resected. Methods Teams participating the study of Pulmonary Metastasectomy Colorectal Cancer (PulMiCC) identified potential candidates for metastasectomy and invited their consent join Stage 1. Baseline data related CRC fitness surgery were collected. Eligible randomization PulMiCC randomized controlled trial (Stage 2). Sites provided case report forms non‐randomized...
Lung cancer is the leading cause of death. Surgery remains main method managing early-stage disease. Minimal-access video-assisted thoracoscopic surgery results in less tissue trauma than open surgery; however, it not known if improves patient outcomes.
Uniportal approaches to video-assisted thoracoscopic surgery (VATS) lobectomy have been described in significant series. Few comparison studies between the two techniques exist. The aim was determine whether uniportal technique had more favourable postoperative outcomes than multiport technique. All VATS lobectomies undertaken at a single university hospital during August 2012 December 2013 were studied. Patients with preoperative opiate use or chronic pain excluded. divided into those and...
Stage III N2 nonsmall cell lung cancer (NSCLC) is a complex disease with poor treatment outcomes. For patients in whom the considered technically resectable, main options include surgery (with neoadjuvant or adjuvant chemotherapy/neoadjuvant chemoradiotherapy (CRT)) CRT followed by immunotherapy (dependent on programmed death ligand 1 status). As there no clear evidence demonstrating survival benefit between these options, patient preference plays an important role. A lack of consensus...
Abstract Background Video-assisted thoracoscopic surgery (VATS) approaches are increasingly used in lung cancer surgery, but little is known about their impact on patients’ health-related quality of life (HRQL). This prospective study measured recovery and HRQL the year after VATS for non-small cell (NSCLC) explored feasibility data collection patients undergoing or open resection. Patients Methods Consecutive referred surgical assessment (VATS surgery) proven/suspected NSCLC completed...
To identify and prioritize technical procedures for simulation-based training to be integrated into the thoracic surgical curriculum.A 3-round Delphi survey was conducted from February 2022 June among 34 key opinion leaders in surgery 14 countries worldwide. The 1st round a brainstorming phase that newly qualified surgeon should able perform. All suggested were categorized, qualitatively analysed sent 2nd round. second investigated: frequency of identified procedure at each institution,...
Vasospasm of arterial conduits used for coronary artery surgery is an important cause graft failure and likely to result partly from raised levels vasoconstrictor substances such as thromboxane A 2 endothelin‐1. Our aim was find pharmacological agents that could prevent agonist‐induced vasospasm. Isometric tension recorded discarded segments human left internal mammary (LIMA). Submaximal contraction evoked by the mimetic U46619 (10 n M ) not inhibited a blocker store‐ receptor‐operated Ca 2+...
Evidence that Enhanced Recovery After Thoracic Surgery (ERAS) improves clinical outcomes is growing. Following the recent publications of international ERAS guidelines in surgery, aim this audit was to capture variation and perceived difficulties implementation, thus helping its development at a national level. We designed an anonymous online survey distributed it via email all 36 centres perform lung lobectomy surgery UK Ireland. It included 38 closed, open multiple-choice questions on core...
8504 Background: Video assisted thoracoscopic surgery (VATS) is a popular access for lung cancer resection. However, there limited information from RCTs in-hospital to one-year clinical efficacy, safety and oncologic outcomes of minimal approach. Methods: VIOLET parallel group multi-center RCT conducted in 9 centers the United Kingdom that recruited participants with known or suspected (cT1-3, N0-1 M0) (ISRCTN13472721). Trial protocol: https://bmjopen.bmj.com/content/9/10/e029507.info....
Many airway management guidelines include the use of exchange catheters (AECs). There are reports, however, harm from their use, both malpositioning and in particular administration oxygen via an AEC leading to barotrauma.We used vitro pig lung model investigate safety administering at 4 different flow rates a high-pressure source 2 AECs: standard catheter soft-tipped catheter. Experiments were performed with positioned either above carina or below it first point resistance advancement...
This study reports the results of an international expert consensus process evaluating assessment intraoperative air leaks (IAL) and treatment postoperative prolonged (PAL) utilizing a Delphi process, with aim helping standardization improving practice.A panel 45 questions was developed submitted to working group experts in minimally invasive lung cancer surgery. Modified methodology used review responses, including 3 rounds voting. The defined priori as >50% agreement among experts....
We determined whether voltage gated K+ (KV) channels are expressed and functional in human detrusor smooth muscleInformation on KV was obtained using electrophysiological patch clamp, immunofluorescence, Western blot isometric tension recording techniquesPatch clamp recordings from cells revealed a Ca2+ independent current that activated by depolarization range near the resting potential of muscle. The inhibited 3,4-diaminopyridine, blocker channels. Antibodies targeted to KValpha1 subunits...