A5034136237- Transplantation: Methods and Outcomes
- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Organ Transplantation Techniques and Outcomes
- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Tracheal and airway disorders
- Mechanical Circulatory Support Devices
- Estrogen and related hormone effects
- Organ and Tissue Transplantation Research
- Lung Cancer Treatments and Mutations
- Cardiac Structural Anomalies and Repair
- Congenital Diaphragmatic Hernia Studies
- Peptidase Inhibition and Analysis
- Trauma and Emergency Care Studies
- Polyomavirus and related diseases
- Head and Neck Cancer Studies
- Stress Responses and Cortisol
- Medical Imaging and Pathology Studies
- Inflammatory mediators and NSAID effects
- Congenital Heart Disease Studies
- Anesthesia and Pain Management
- Renal Transplantation Outcomes and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
Mater Misericordiae University Hospital
2010-2024
St. Vincent's University Hospital
2013-2024
Merck & Co., Inc., Rahway, NJ, USA (United States)
2023-2024
Edinburgh Royal Infirmary
2022
Royal College of Surgeons in Ireland
2020
Cork University Hospital
2006-2019
ProQuest (United States)
2019
Australia and New Zealand Banking Group
2019
Royal Australasian College of Surgeons
2019
Beaumont Hospital
2018
Psychological stress increases the circulating levels of hormones cortisol and norepinephrine (NE). Chronic exposure to elevated has been linked a reduced response chemotherapy through induction DNA damage. We hypothesize that hormone signalling may induce damage production reactive oxygen species (ROS)/reactive nitrogen (RNS) interference in repair processes, promoting tumourigenesis. Breast cancer cell lines were incubated with physiological NE presence absence receptor antagonists...
To identify and prioritize technical procedures for simulation-based training to be integrated into the thoracic surgical curriculum.A 3-round Delphi survey was conducted from February 2022 June among 34 key opinion leaders in surgery 14 countries worldwide. The 1st round a brainstorming phase that newly qualified surgeon should able perform. All suggested were categorized, qualitatively analysed sent 2nd round. second investigated: frequency of identified procedure at each institution,...
Irish health services have been repurposed in response to the COVID-19 pandemic. Critical care re-focused on management of patients. This presents a major challenge for specialities such as cardiothoracic surgery that are reliant intensive unit (ICU) resources.The aim this study was evaluate impact pandemic activity at surgical National Cardiothoracic Surgery and Transplant Centre.A comparison performed cardiac transplant caseload first 4 months 2019 2020 using data collected prospectively...
OBJECTIVE: To compare the effects of three cyclooxygenase-2 (COX-2) inhibitors: nimesulide, meloxicam, and celecoxib, which exhibit varying COX-2 selectivity, on contractile activity in pregnant (before after labor) nonpregnant human myometrial tissue vitro. METHODS: Isometric tension recording was performed under physiologic conditions isolated strips obtained from 33 women undergoing hysterectomy or either elective emergency cesarean section. The cumulative additions celecoxib (between 1...
Transplant rejection remains a clinical problem despite therapies that focus on lymphocyte suppression, with little attention focused the neutrophil. Neutrophils are however first leukocyte to infiltrate allograft, capable of causing myocardial damage and may facilitate lymphocytes recruitment. We hypothesised an early allograft neutrophil infiltration influences severity.Myocardial was assessed using CD15 myeloperoxidase immunohistochemistry surveillance endomyocardial biopsy specimens from...
Postoperative nausea and vomiting is common after cardiac surgery may contribute to significant morbidity. Gastric decompression during anesthesia has been used for postoperative prophylaxis in shorter duration noncardiac with conflicting results. We tested the hypothesis that gastric elective coronary revascularization cardiopulmonary bypass continued afterwards until tracheal extubation would reduce incidence of or retching nausea. In a prospective, randomized, cohort study, 104 patients...
Previous studies from our group demonstrated the anti-inflammatory properties of statins on cardiopulmonary bypass (CPB), through inhibition neutrophil transendothelial migration. We sought to determine utility preoperative statin patients undergoing cardiac surgery, investigate any moderating effects systemic inflammatory response (SIRS) with CPB, and evaluate clinical impact patients. This is a prospective, randomised controlled trial national regulatory body approval. Eligible were...
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease that results in progressive respiratory failure and death. Antifibrotic therapy has been shown to slow progression [1, 2]. For many patients [3], transplantation the only intervention recognised provide significant survival benefit [4]. IPF commonly affects older patients, with median age at diagnosis of 66 years old [5]. Without transplantation, from 2–4 However, registry data indicates impaired outcomes following for 6]. These...
We have previously demonstrated the role of univentricular pacing modalities in influencing coronary conduit flow immediate post-operative period cardiac surgery patient. wanted to determine mechanism this improved and, addition, explore possible benefits with biventricular pacing. Sixteen patients undergoing first time elective artery bypass grafting who required following were recruited. Comparison output and was performed between VVI DDD a single right ventricular lead placement. Cardiac...
More data are needed regarding the radiology, co-morbidities and natural history of smoking-related interstitial fibrosis (SRIF), a common pathological finding, mainly described heretofore in association with lung cancer, where respiratory bronchiolitis (RB) usually co-exists. We prospectively acquired high resolution CT scan (edge-enhancing reconstructions) to detect any radiologic abnormality (ILA) individuals who ultimately underwent surgical lobectomy for cancer (n = 20),...
Preoperative methicillin-resistant Staphylococcus aureus (MRSA) carriage is associated with higher rates of postoperative MRSA infection. Carriage can be eradicated but this requires delaying surgery, which presents a dilemma when the surgery urgent. We analysed incidence preoperative and impact on outcomes in cardiac population.Patient data were collected prospectively from 2000 to 2007 (n=3789). screening performed at preadmission clinic for elective patients admission hospital all...