A5005271692- Lung Cancer Diagnosis and Treatment
- Cancer survivorship and care
- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Tracheal and airway disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Reconstructive Surgery and Microvascular Techniques
- COVID-19 Clinical Research Studies
- Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Trauma Management and Diagnosis
- Pleural and Pulmonary Diseases
- Voice and Speech Disorders
- Oral and Maxillofacial Pathology
- Acute Ischemic Stroke Management
- RNA Research and Splicing
- Reconstructive Facial Surgery Techniques
- Esophageal and GI Pathology
- Venous Thromboembolism Diagnosis and Management
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
University of Electronic Science and Technology of China
2010-2025
Sichuan Cancer Hospital
2016-2025
Wuhan Polytechnic University
2023-2025
Fudan University
2021-2025
Ningxia Medical University
2025
First Affiliated Hospital of GuangXi Medical University
2025
Guangxi Medical University
2025
China Medical University
2013-2024
Yale University
2022-2024
Zhejiang University
2020-2024
Abstract Background Grip strength is a widely used and well-validated measure of overall health that increasingly understood to index risk for psychiatric illness neurodegeneration in older adults. However, existing work has not examined how grip relates comprehensive set mental outcomes, which can detect early signs cognitive decline. Furthermore, whether brain structure mediates associations between cognition remains unknown. Methods Based on cross-sectional longitudinal data from over...
Breast cancer is one of the most common malignant cancers among women. Cancer cells and adjacent determine development disease. Tumor associated macrophages (TAMs) are involved in regulation different stages progression. LncRNAs play an important role tumor growth metastasis. However, function lncRNA macrophage cell interaction poorly described. Here we reported that SNHG1 functioned as a modulator M2 polarization regulated angiogenesis. We indicated knockdown inhibited by suppression STAT6...
We aimed to evaluate the efficacy and feasibility of patient-reported outcome (PRO)-based symptom management in early period after lung cancer surgery.Before surgery, patients with clinically diagnosed were randomly assigned 1:1 receive postoperative PRO-based or usual care. All reported symptoms on MD Anderson Symptom Inventory-Lung Cancer presurgery, daily postsurgery, twice a week discharge for up 4 weeks via an electronic PRO system. In intervention group, treating surgeons responded...
After complete spinal cord injuries (SCI), segments below the lesion maintain inter-segmental communication via intraspinal propriospinal network. However, it is unknown whether selective manipulation of these circuits can restore locomotor function in absence brain-derived inputs. By taking advantage compromised blood-spinal barrier following SCI, we optimized a set procedures which AAV9 vectors administered tail vein efficiently transduce neurons lesion-adjacent after thoracic crush injury...
Digital technology policies beyond the traditional urban–rural dichotomy have become critical in economic and industrial integration. Few empirical studies examine specific impact pathway of digital economy policy on urbanisation, especially urbanisation driven by economy. This study attempts to reveal linkage between provide a reference for cities aiming achieve urban transformation through upgrading their economies. Based previous research, this work examines Chongqing, major city terms...
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary point, may be published when key planned co-primary or secondary analyses are not yet available. Trial Updates provide an opportunity to disseminate additional results from studies, in JCO elsewhere, for which point has already been reported. We previously reported superior symptom control of electronic patient-reported outcome (ePRO)–based management...
Carvacrol, a component of thyme oil, as novel antitumor agent, has been implicated in several types cancer cells. However, the mechanisms underlying effect carvacrol human oral squamous cell carcinoma (OSCC) remain unclear. Here, we report that significantly inhibits tumor proliferation, metastasis and invasion, induces apoptosis OSCC. Our results demonstrated molecular Tca-8113 G1/S cycle arrest through downregulation CDK regulator CCND1 CDK4, upregulation inhibitor P21. Further analysis...
Exposure to addictive drugs triggers synaptic plasticity in reward-related brain regions, such as the midbrain, nucleus accumbens and prefrontal cortex. Effects of chronic drug exposure on other areas have not been fully investigated. Here, we characterize motor cortex after methamphetamine self-administration rats. We show that this causes a loss corticostriatal rat slices impaired learning rotarod task. These findings are paralleled by observation lack transcranial magnetic...
Previous studies have proved that periodontitis is an independent risk factor of oral squamous cell carcinoma (OSCC) epidemiologically. Along with the important role microbiota in cancer process and specific anatomical position, our study explored microbial composition functions gingival (GSCC). GSCC patients (n = 10), matched 15), healthy individuals 15) were recruited. Saliva, subgingival plaque, tongue dorsum, buccal mucosa, cancerous tissue, paracancerous tissue samples collected. 16S...
Chronic liver diseases of all etiologies exist along a spectrum with varying degrees hepatic fibrosis. Despite accumulating evidence implying associations between fibrosis and cognitive functioning, there is limited research exploring the underlying neurobiological factors possible mediating role inflammation on liver-brain axis.
Background: Electronic symptom monitoring via patient-reported outcomes in surgical oncology is limited owing to lengthy instruments and non-specific items common outcome instruments. To establish electronic through a clinically relevant fit-for-purpose core set of patients undergoing lung cancer surgery. Materials methods: One qualitative (Cohort 1) two prospective studies (Cohorts 2 3) were conducted between 2018 2022. Patients surgery recruited. Items symptoms daily functioning generated...
Abstract According to the global cancer statistic, lung is one of most dangerous tumors, which poses a serious threat human health. Exploration mechanism and new targeted therapeutic measures always hot topic. Long noncoding RNA (lncRNA) an important factor affecting development tumors. However, research on lncRNA in progress needs be further expanded. In this study, we found that expression GMDS‐AS1 was significantly reduced adenocarcinoma (LUAD) tissues cells. Upregulated can inhibit...
Proteotoxic stress drives numerous degenerative diseases. Cells initially adapt to misfolded proteins by activating the unfolded protein response (UPR), including endoplasmic-reticulum-associated degradation (ERAD). However, persistent triggers apoptosis. Enhancing ERAD is a promising therapeutic approach for misfolding The ER-localized Zn
Background This study investigated the quality of life Chinese patients with malignant tumors who had undergone immediate free flap reconstruction surgery. In addition, we compared 2 groups patients: those received radial forearm surgery and others anterolateral thigh perforator Methods Quality was assessed using Medical Outcomes Study‐Short Form‐36 (MOS SF‐36) University Washington Life (UW‐QOL) questionnaires 12 months after reconstruction. Results A total 121 163 were returned (74.2%)....
Abstract Accurate classification of adenocarcinoma (AC) and squamous cell carcinoma (SCC) in lung cancer is critical to physicians’ clinical decision-making. Exhaled breath analysis provides a tremendous potential approach non-invasive diagnosis but was rarely reported for subtypes classification. In this paper, we firstly proposed combined method, integrating K-nearest neighbor classifier (KNN), borderline2-synthetic minority over-sampling technique (borderlin2-SMOTE), feature reduction...
Following lung cancer surgery, patients often experience severe symptoms which are not properly assessed at discharge. The aim of this study was to identify the clinical presentation discharge and influencing factors postoperative in who have undergone surgery.This cross-sectional analysed data from participated a prospective cohort that enrolled underwent surgery six tertiary hospitals People's Republic China, November 2017 January 2020. Patient were measured using MD Anderson Symptom...