A5068243804- Invertebrate Immune Response Mechanisms
- Insect Resistance and Genetics
- Neurobiology and Insect Physiology Research
- Insect symbiosis and bacterial influences
- Insect Utilization and Effects
- Insect and Arachnid Ecology and Behavior
- Insect and Pesticide Research
- Antimicrobial Peptides and Activities
- Studies on Chitinases and Chitosanases
- Entomopathogenic Microorganisms in Pest Control
- Aquaculture disease management and microbiota
- Silk-based biomaterials and applications
- Insect Pest Control Strategies
- Enzyme-mediated dye degradation
- Iron Metabolism and Disorders
- Mosquito-borne diseases and control
- Chronic Lymphocytic Leukemia Research
- Vector-borne infectious diseases
- CRISPR and Genetic Engineering
- Protease and Inhibitor Mechanisms
- Lymphoma Diagnosis and Treatment
- Insect-Plant Interactions and Control
- Enzyme Production and Characterization
- Trypanosoma species research and implications
- Viral Infectious Diseases and Gene Expression in Insects
Kansas State University
2016-2025
Kazan State Medical University
2024
Saratov State Medical University
2024
Ministry of Health of the Russian Federation
2024
Rostov State Medical University
2024
Research Institute of Human Morphology
2024
Russian Scientific Center of Surgery
2024
University of Oxford
2024
Building Research Institute
2024
Mirai Hospital
2024
Abstract Social insects are able to mount both group‐level and individual defences against pathogens. Here we focus on defences, by presenting a genome‐wide analysis of immunity in social insect, the honey bee Apis mellifera . We present models for each four signalling pathways associated with immunity, identifying plausible orthologues nearly all predicted pathway members. When compared sequenced Drosophila Anopheles genomes, bees possess roughly one‐third as many genes 17 gene families...
Mosquitoes are vectors of parasitic and viral diseases immense importance for public health. The acquisition the genome sequence yellow fever Dengue vector, Aedes aegypti (Aa), has enabled a comparative phylogenomic analysis insect immune repertoire: in Aa, malaria vector Anopheles gambiae (Ag), fruit fly Drosophila melanogaster (Dm). Analysis signaling pathways response modules reveals both conservative rapidly evolving features associated with different functional gene categories...
Cuticle tanning (or sclerotization and pigmentation) in invertebrates involves the oxidative conjugation of proteins, which renders them insoluble hardens darkens color exoskeleton. Two kinds phenoloxidases, laccase tyrosinase, have been proposed to participate tanning, but proof true identity enzyme(s) responsible for this process has elusive. We report cloning cDNAs laccases tyrosinases from red flour beetle, Tribolium castaneum , as well their developmental patterns expression. To test...
Abstract Functional analysis of the two chitin synthase genes, TcCHS1 and TcCHS2 , in red flour beetle, Tribolium castaneum revealed unique complementary roles for each gene. TcCHS1‐ specific RNA interference (RNAi) disrupted all three types moult (larval–larval, larval–pupal pupal–adult) greatly reduced whole‐body content. Exon‐specific RNAi showed that splice variant 8a was required both larval‐pupal pupal‐adult moults, whereas 8b only latter. ‐specific had no effect on metamorphosis or...
A lipopolysaccharide-specific lectin, immulectin-2, was isolated from plasma of the tobacco hornworm,Manduca sexta. Immulectin-2 has specificity for xylose, glucose, lipopolysaccharide, and mannan. cDNA clone encoding immulectin-2 an Escherichia coli-inducedM. sexta larval fat body library. The is 1253 base pairs long, with open reading frame 981 pairs, a 327-residue polypeptide. member C-type lectin superfamily. It consists two carbohydrate recognition domains, which similar to organization...
Activation of pro-phenol oxidase (proPO) in insects and crustaceans is important defense against wounding infection. The proPO zymogen activated by a specific proteolytic cleavage. PO oxidizes phenolic compounds to produce quinones, which may help kill pathogens can also be used for synthesis melanin seal wounds encapsulate parasites. We have isolated from the tobacco hornworm, Manduca sexta , serine proteinase that activates proPO, cloned its cDNA. activating (PAP) hydrolyzed artificial...
Pattern recognition proteins function in innate immune responses by binding to molecules on the surface of invading pathogens and initiating host defense reactions. We report purification molecular cloning a cDNA for 53-kDa β1,3-glucan-recognition protein from tobacco hornworm,Manduca sexta. This is constitutively expressed fat body secreted into hemolymph. The contains region with sequence similarity several glucanases, but it lacks glucanase activity. It binds agglutinates yeast, as well...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular structure of an apolipoprotein determined at 2.5-.ANG. resolutionDeborah R. Breiter, Michael Kanost, Matthew M. Benning, Gary Wesenberg, John H. Law, A. Wells, Ivan Rayment, and Hazel HoldenCite this: Biochemistry 1991, 30, 3, 603–608Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January...
Proteolytic activation of prophenoloxidase in insects is a component the host defense system against invading pathogens and parasites. We have purified from hemolymph tobacco hornworm, Manduca sexta, new serine proteinase that cleaves prophenoloxidase. This enzyme, designated prophenoloxidase-activating proteinase-2 (PAP-2), differs another PAP, previously isolated integuments same insect (PAP-1). PAP-2 contains two clip domains at its amino terminus catalytic domain carboxyl terminus,...