A5061685689- Genetics, Aging, and Longevity in Model Organisms
- CRISPR and Genetic Engineering
- Chromosomal and Genetic Variations
- RNA Research and Splicing
- Neurobiology and Insect Physiology Research
- RNA modifications and cancer
- Smart Parking Systems Research
- MicroRNA in disease regulation
- Hepatitis C virus research
- Monoclonal and Polyclonal Antibodies Research
- Insect and Arachnid Ecology and Behavior
- SARS-CoV-2 and COVID-19 Research
- Vasculitis and related conditions
- Influenza Virus Research Studies
- Antifungal resistance and susceptibility
- Tactile and Sensory Interactions
- Sinusitis and nasal conditions
- Teratomas and Epidermoid Cysts
- Virology and Viral Diseases
- Insect Utilization and Effects
- Asphalt Pavement Performance Evaluation
- Fetal and Pediatric Neurological Disorders
- Hydrology and Watershed Management Studies
- Innovation Diffusion and Forecasting
- Digital Imaging for Blood Diseases
Whitehead Institute for Biomedical Research
2021-2024
Manipal Academy of Higher Education
2023
Institute of Management Technology
2023
Guru Ghasidas Vishwavidyalaya
2022
Manipal University Jaipur
2022
Max Super Speciality Hospital
2022
Harvard University
2015-2021
Hôpital Militaire Avicenne
2021
Boston VA Research Institute
2019-2021
Max Healthcare
2021
Gene silencing mediated by dsRNA (RNAi) can persist for multiple generations in Caenorhabditis elegans (termed RNAi inheritance). Here we describe the results of a forward genetic screen C. that has identified six factors required inheritance: GLH-1/VASA, PUP-1/CDE-1, MORC-1, SET-32, and two novel nematode-specific term here (heritable defective) HRDE-2 HRDE-4 The new inheritance exhibit mortal germline (Mrt) phenotypes, which show is likely caused epigenetic deregulation germ cells. We also...
Acquisition of new proteins by viruses usually occurs through horizontal gene transfer or duplication, but another, less common mechanism is the usage completely partially overlapping reading frames. A case acquisition a protein introduction start codon in an alternative frame encoded open (orf) 9b SARS coronavirus. This overlaps with nucleocapsid (N) (orf9a). Our findings indicate that orf9b features discordant codon-usage pattern. We analyzed evolution concert orf9a using sequence data...
Abstract Background Insects detect environmental chemicals via a large and rapidly evolving family of chemosensory receptor proteins. Although our understanding the molecular genetic basis for Drosophila chemoreception has increased enormously in last decade, similar other insects remains limited. The tobacco hornworm, Manduca sexta, long been an important model insect chemosensation, particularly from ecological, behavioral, physiological standpoints. It is also major agricultural pest on...
Temperature modulates the peripheral taste response of many animals, in part by activating transient receptor potential (Trp) cation channels. We hypothesized that temperature would also modulate responses larval Manduca sexta. recorded excitatory lateral and medial styloconic sensilla to chemical stimuli at 14, 22, 30 °C. The 5 stimuli—a salt (KCl), 3 sugars (sucrose, glucose, inositol) an alkaloid (caffeine)—were unaffected temperature. In contrast, aversive compound, aristolochic acid...
MicroRNAs (miRNAs) associate with Argonaute (AGO) proteins to form complexes that direct mRNA repression. miRNAs are also the subject of regulation. For example, some destabilized through a pathway in which pairing specialized transcripts recruits ZSWIM8 E3 ubiquitin ligase, polyubiquitinates AGO, leading its degradation and exposure miRNA cellular nucleases. Here, we found 22 C. elegans sensitive loss EBAX-1, ortholog nematodes, implying these might be this target-directed (TDMD). The...
Groundwater is best portrayed as the world's truly covered up treasure. It has had an effect in giving safe drinking water during dry season. biggest open store of fresh (barring ice sheets and icy masses) comprises around 94% all water. Rajasthan witnesses scarcity problem therefor, it aims at forecasting rainfall state, based on different features provided by state government. The motivation paper to predict groundwater level so that proper conservative methods can be applied raise ground...
The gravity of "second wave" COVID-19 has effaced many new challenges in India; mucormycosis being a recent one. Diabetes mellitus (DM) is known significant risk factor for mucormycosis. Here, we present our experience with rhino-orbital-cerebral (ROCM) during the wave COVID-19" at tertiary health care centre North India.This case series includes four cases ROCM that were managed by neurosurgical team view ofcerebral involvement.All an exception one (Case 1), had history treatment pneumonia....
Abstract In today’s society, where independent living is becoming increasingly important, it can be extremely constricting for those who are blind. Blind and visually impaired (BVI) people face challenges because they need manual support to prompt information about their environment. this work, we took our first step towards developing an affordable high-performing eye wearable assistive device, DRISHTI, provide visual navigation assistance BVI people. This system comprises a camera module,...
Abstract Mobile genetic elements threaten genome integrity in all organisms. MUT-2/RDE-3 is a ribonucleotidyltransferase required for transposon silencing and RNA interference (RNAi) C. elegans . When tethered to RNAs heterologous expression systems, RDE-3 can add long stretches of alternating non-templated uridine (U) guanosine (G) ribonucleotides the 3’ termini these (polyUG or pUG tails). Here, we show that, its natural context , adds tails RNAs, as well targets RNAi. with more than 16...
Abstract Noncoding RNAs have emerged as mediators of transgenerational epigenetic inheritance (TEI) in a number organisms. A robust example RNA-directed TEI is the gene silencing states following RNA interference (RNAi) metazoan C. elegans . During RNAi inheritance, transmitted by self-perpetuating cascade siRNA-directed poly(UG) tailing mRNA fragments (pUGylation), followed siRNA synthesis from poly(UG)-tailed templates (termed pUG RNA/siRNA cycling). Despite nature cycling, finite,...
ABSTRACT MicroRNAs (miRNAs) associate with Argonaute (AGO) proteins to form complexes that direct mRNA repression. miRNAs are also the subject of regulation. For example, some destabilized through a pathway in which pairing specialized transcripts recruits ZSWIM8 E3 ubiquitin ligase, polyubiquitinates AGO, leading its degradation and exposure miRNA cellular nucleases. Here, we found 22 C. elegans sensitive loss EBAX-1, ortholog nematodes, implying these might be this target-directed (TDMD)....
In today's society, where independent living is becoming increasingly important, it can be extremely constricting for those who are blind. Blind and visually impaired (BVI) people face challenges because they need manual support to prompt information about their environment. this work, we took our first step towards developing an affordable high-performing eye wearable assistive device, DRISHTI, provide visual navigation assistance BVI people. This system comprises a camera module, ESP32...