A5052889912- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Lung Cancer Research Studies
- Pleural and Pulmonary Diseases
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Virus-based gene therapy research
- Tracheal and airway disorders
- Cancer Research and Treatments
- Cancer Diagnosis and Treatment
- Myasthenia Gravis and Thymoma
- Cancer, Hypoxia, and Metabolism
- Multiple and Secondary Primary Cancers
- Cardiac, Anesthesia and Surgical Outcomes
- Head and Neck Cancer Studies
- Congenital Diaphragmatic Hernia Studies
- Herpesvirus Infections and Treatments
- Pituitary Gland Disorders and Treatments
- CAR-T cell therapy research
- Global Cancer Incidence and Screening
- Meningioma and schwannoma management
- Metastasis and carcinoma case studies
Montefiore Medical Center
2021-2025
Albert Einstein College of Medicine
2021-2025
Montefiore Einstein Comprehensive Cancer Center
2023-2024
Montefiore Health System
2021-2024
Cornell University
2014-2023
RELX Group (United States)
2023
New York Proton Center
2023
Faculty of 1000 (United States)
2023
The Bronx Defenders
2023
New York Hospital Queens
2013-2022
The epidermal growth-factor receptor (EGFR) tyrosine kinase inhibitor erlotinib has been proven to be highly effective in the treatment of nonsmall cell lung cancer (NSCLC) harboring oncogenic EGFR mutations. majority patients, however, will eventually develop resistance and succumb disease. Recent studies have identified secondary mutations (EGFR T790M) amplification N-Methyl-N′-nitro-N-nitroso-guanidine (MNNG) HOS transforming gene (MET) oncogene as two principal mechanisms acquired...
Abstract Tumors systemically initiate metastatic niches in distant target organs. These niches, composed of bone marrow–derived hematopoietic cells, provide permissive conditions for future metastases. However, the mechanisms by which these cells mediate outgrowth tumor are not completely known. Using mouse models spontaneous breast cancer, we show enhanced recruitment CD11b+Gr1+ myeloid progenitor premetastatic lungs. Gene expression profiling revealed that from lungs express versican, an...
In Brief Objective: Several population-based studies have shown that the total number of surgically removed lymph nodes is independently associated with overall and disease-free survival in a variety gastrointestinal cancers. this retrospective study, impact nodal count on esophageal cancer was examined using single institution surgical database. Methods: We conducted review 264 patients treated by esophagectomy without neoadjuvant therapy between January 1988 December 2006. The association...
We examined the Nationwide Inpatient Sample (NIS) database to compare short-term postoperative outcomes following open and thoracoscopic lobectomy. Thoracoscopic (video-assisted thoracic surgery) lobectomy has been demonstrated be associated with fewer complications compared thoracotomy in several large case series. However, as no randomized trial performed, there are many who question this. NIS for all patients undergoing their principal procedure either via or from 2007 08. of these two...
Purpose The American Society for Radiation Oncology (ASTRO) produced an evidence-based guideline on treatment with stereotactic body radiotherapy (SBRT) patients early-stage non-small-cell lung cancer. ASCO has a policy and set of procedures endorsing and/or adapting clinical practice guidelines that have been developed by other professional organizations. Methods ASTRO Evidence-Based Guideline Stereotactic Body Radiotherapy Early-Stage Non-Small-Cell Lung Cancer was reviewed developmental...
Chylothorax remains an uncommon but challenging clinical problem. Thoracic duct ligation is the treatment of choice for postsurgical patients. However, optimal traumatic patients unclear. We wanted to examine outcomes with high output or recurrent chylothorax who were treated by surgical means.From December 1992 April 2008, 29 underwent procedures (> 1 L/day) (16) (13). analyzed these determine approach, perioperative complications, and approach.Of patients, 12 developed following...
Pulmonary fibrosis is characterized by an inflammatory response that includes macrophages, neutrophils, lymphocytes, and mast cells. The purpose of this study was to evaluate whether cells play a role in initiating pulmonary fibrosis. induced with bleomycin mast-cell-deficient WBB6F1-W/Wv (MCD) mice their congenic controls (WBB6F1-+/+). Mast cell deficiency protected against bleomycin-induced fibrosis, but protection reversed the re-introduction lungs MCD mice. Two mediators were identified...
Significance p53 is one of the most intensively studied tumor-suppressor genes. We identified a naturally occurring isoform, generated by an alternative-splicing event, that, although lacking transcriptional activity and canonical tumor suppressor functions, able to reprogram cells toward acquisition metastatic features via cyclophilin D interaction in mitochondria matrix. Interestingly, this isoform expressed on tissue injury tumors characterized increased spread. In some these tumors,...
Cancer cells undergo a metabolic reprogramming but little is known about alterations of other within tumors. We use mass spectrometry-based profiling and pathway-based systems analysis to compare 21 primary human lung cancer-associated fibroblast lines (CAF) "normal" (NF) generated from adjacent nonneoplastic tissue. CAFs are protumorigenic, although the mechanisms by which support tumors have not been elucidated. identified several pathways whose metabolite abundance globally distinguished...