A5007849153- Ion channel regulation and function
- Infant Development and Preterm Care
- Neuroscience and Neuropharmacology Research
- Estrogen and related hormone effects
- Lipid Membrane Structure and Behavior
- Cancer, Stress, Anesthesia, and Immune Response
- Cerebral Palsy and Movement Disorders
- Neonatal and fetal brain pathology
- Family and Disability Support Research
- Neonatal Respiratory Health Research
- Receptor Mechanisms and Signaling
- Corneal surgery and disorders
- Telomeres, Telomerase, and Senescence
- Neurobiology and Insect Physiology Research
- Fetal and Pediatric Neurological Disorders
- Stress Responses and Cortisol
- Mast cells and histamine
- Corneal Surgery and Treatments
- Nitric Oxide and Endothelin Effects
- Olfactory and Sensory Function Studies
- Wound Healing and Treatments
- Diet and metabolism studies
- Neuropeptides and Animal Physiology
- Epigenetics and DNA Methylation
- Nicotinic Acetylcholine Receptors Study
University of Brighton
2014-2023
University of Pittsburgh
2019-2022
Virginia Department of Health
2018-2019
Johns Hopkins University
1986-2015
Johns Hopkins Medicine
2001-2015
University of Kent
2007-2009
Great Ormond Street Hospital
2005
University College London
1983-2005
Queen's Medical Centre
1998
University of Sussex
1997
Legislatively mandated programs for early intervention on behalf of handicapped infants often stipulate the inclusion physical therapy as a major component treatment cerebral palsy. To evaluate effects therapy, we randomly assigned 48 (12 to 19 months age) with mild severe spastic diplegia receive either 12 (Group A) or 6 preceded by infant stimulation B). The infant-stimulation program included motor, sensory, language, and cognitive activities increasing complexity. Masked outcome...
Psychological stress increases the circulating levels of hormones cortisol and norepinephrine (NE). Chronic exposure to elevated has been linked a reduced response chemotherapy through induction DNA damage. We hypothesize that hormone signalling may induce damage production reactive oxygen species (ROS)/reactive nitrogen (RNS) interference in repair processes, promoting tumourigenesis. Breast cancer cell lines were incubated with physiological NE presence absence receptor antagonists...
The immune system plays an important role in controlling epithelial ovarian cancer (EOC). EOC is considered to be a "cold tumour," tumour that has not triggered strong response by the system. However, infiltrating lymphocytes (TILs) and expression of programmed cell death ligand (PD-L1) are used as prognostic indicators EOC. Immunotherapy such PD-(L)1 inhibitors have shown limited benefit Since affected behavioural stress beta-adrenergic signalling pathway, this study aimed explore impact...
Primary cultures of ovine pituitary cells were used to characterize the effects estradiol on number GnRH receptors. Number receptors was determined by specific binding a saturating dose radioiodinated analog. Estradiol stimulated an increase in that dose-dependent and had time course similar observed vivo. at concentrations from 0.4 40 nM increased (p < 0.05) relative controls. Numbers 8 24 h after addition estradiol, with maximum occurring 12 h. Actinomycin D (10 μg/ml) cycloheximide (25...
The innate immune system acts as the body’s frontline defense, detecting and responding to pathogenic threats with remarkable precision. Central this defense are inflammatory markers, including cytokines, chemokines, acute-phase proteins, cellular mediators. These markers not only recognize infections damage but also orchestrate cell recruitment signal activation of adaptive immunity. Key cytokines such TNF-α, IL-1, IL-6 play dual roles in promoting inflammation restoring homeostasis....
Type 1 diabetes mellitus (T1DM) is a chronic condition requiring effective management strategies to achieve glycemic stability and enhance quality of life (QoL). Adolescents with T1DM face unique challenges due physiological psychosocial factors, making dietary interventions crucial for optimizing outcomes. This review compared the effects low-carbohydrate diet (LCD) versus standard intake (SDI) on variability QoL among adolescents over three months. Using narrative methodology, article...
Objective: Our hypothesis was that the degree of antenatally diagnosed cerebral ventriculomegaly is related to aneuploidy, perinatal mortality and long-term neurological morbidity. Methods: Ninety-one cases identified from 1 June 1994 July 1999 were examined for prenatal, intrapartum neonatal complications. Pediatric follow-up reviewed infants with birth up as long 4 years. Minor morbidity defined a score 70-80 on clinical adaptive test/clinical linguistic auditory milestone scale included...
Our hypothesis was that the degree of antenatally diagnosed cerebral ventriculomegaly is related to aneuploidy, perinatal mortality and long-term neurological morbidity.Ninety-one cases identified from 1 June 1994 July 1999 were examined for prenatal, intrapartum neonatal complications. Pediatric follow-up reviewed infants with birth up as long 4 years. Minor morbidity defined a score 70-80 on clinical adaptive test/clinical linguistic auditory milestone scale included mild motor or language...
The roll-out of the Pfizer-BioNTech BNT162b2 COVID-19 vaccine has brought many logistical challenges, such as absence comprehensive stability data leading to strict handling instructions during dilution and administration. Accidental mishandling therefore presents challenging clinical dilemmas, which often led providers err on side caution discard mishandled vials rather than risk administering ineffective vaccine. This study aims answer key questions about vaccine's allow for a more...
BK channels regulate vascular tone by hyperpolarizing smooth muscle in response to fluctuating calcium concentrations. Oestrogen has been reported lower blood pressure increasing channel open probability through direct binding the regulatory β1-subunit(s) associated with channel. The present investigation demonstrates that 17β-oestradiol activates complex burst duration of openings. A subconductance state was observed 25% recordings following addition and could reflect uncoupling between...
The human cornea is a tri-laminar structure composed of several cell types with substantial mitotic potential. Age-related changes in the are associated declining visual acuity and onset overt age-related corneal diseases. Corneal transplantation commonly used to restore vision patients damaged or diseased corneas. However, supply donor tissue limited, thus there considerable interest development tissue-engineered alternatives. A major obstacle these approaches short replicative lifespan...
Background: Current literature supporting treatment strategies for osteochondritis dissecans (OCD) has limited prognostic utility. Presently, there is no gold standard an OCD "healing" outcome. Accurate and reliable determination of the healed status on basis radiographs would be valuable to provide a guide evidence-based OCD. The purpose this study was determine interrater intrarater reliability radiographic assessment lesion healing in knee. Methods: A hospital database identified 39...
Abstract Objective There is substantial evidence demonstrating that transferring patients between care providers a high-risk area for medicines management. This study aimed to investigate the effect of sending patients’ hospital discharge letters their nominated community pharmacists on number discrepancies patient’s general practitioner (GP) records and letter self-described medication regime letter. Methods In randomised, controlled trial, 33 participants in two groups, control...
Sodium ion transport across a phospholipid bilayer has been demonstrated by new class of transmembrane channel mimetic compounds in which the filtering effect calixarene coupled to membrane penetrating qualities commercial surfactant.