A5077057310- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Airway Management and Intubation Techniques
- Medical Imaging and Pathology Studies
- Thyroid and Parathyroid Surgery
- Pleural and Pulmonary Diseases
- Laser Applications in Dentistry and Medicine
- Neuroendocrine Tumor Research Advances
- Respiratory Support and Mechanisms
- Advanced Radiotherapy Techniques
- Lung Cancer Research Studies
- Transplantation: Methods and Outcomes
- Lung Cancer Treatments and Mutations
- Trauma Management and Diagnosis
- Neuroblastoma Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Organ Transplantation Techniques and Outcomes
- Neonatal Respiratory Health Research
- Mechanical Circulatory Support Devices
- Myasthenia Gravis and Thymoma
- Voice and Speech Disorders
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac Arrest and Resuscitation
- Congenital Diaphragmatic Hernia Studies
Philipps University of Marburg
2016-2025
Universitätsklinikum Gießen und Marburg
2013-2023
Klinikum Magdeburg
2016-2021
University Medical Center Freiburg
2008-2014
Universitätsklinik für Chirurgie Wien
2008-2009
University of Freiburg
2006-2008
Klinik Schillerhöhe
2005-2008
Robert Bosch Hospital
2008
Hôpital Sainte-Marguerite
2007
Aix-Marseille Université
2007
Objective: Sublobar resections spare pulmonary function and offer a method of increasing resection rates in patients with lung cancer limited functional operability. Previous studies demonstrated an increased local recurrence rate following wedge compared to segmentectomies stage IA non-small cell (NSCLC). However, prognostic impact this observation has never been shown is still under debate. Therefore, study performed analyse the cancer-related survival sublobar patients. Methods: Over...
Segmentectomy has recently been suggested as alternative to lobectomy for curative treatment of early-stage non-small cell lung cancer (NSCLC). This study was performed investigate if localisation the resected segment or width resection margins influence local recurrence following complete segmentectomy stage IA NSCLC.Between 1987 and 2002, 49 segmentectomies 150 lobectomies were in patients with pT1pN0cM0-NSCLC our institution. Indications a limited pulmonary function severe comorbidity....
Extracellular nucleotides have recently been identified as proinflammatory mediators involved in asthma pathogenesis by signaling via purinergic receptors, but the role of receptor type 6 (P2Y6R) has not previously investigated.To investigate P2Y6R pathogenesis.Acute and chronic OVA model also HDM allergic inflammation C57Bl/6 mice treated with specific antagonist P2Y6R(-/-) were evaluated for classical features asthmatic inflammation. In addition, primary epithelial cell culture from human...
Advanced non-small cell lung cancer (NSCLC) management has become profoundly linked to disease stage and molecular profile. Targeted therapies immunotherapy have refined treatment options. Developments in minimally invasive surgery endovascular techniques necessitate reevaluation of T4-NSCLC resectability, especially for that invades the thoracic aorta (T4invAo). In cases suspected aortic invasion anticipation surgery, a three-dimensional computed tomography (3D CT) reconstruction is...
Typical and atypical carcinoid tumors belong to the neuroendocrine lung tumors. They have low recurrence proliferation rate, lymph node, distant metastases. Nevertheless, these shown a more aggressive behavior. In last years, microRNAs were screened as new tumor markers for their potential diagnostic therapeutic relevance. The expression of hsa-let-7b-5p, hsa-let-7f-5p, hsa-miR-222-3p, targets HMGA2 (high-mobility group A2) CDKN1B (cyclin-dependent kynase inhibitor 1B, p27kip1) was evaluated...
Introduction: Paraneoplastic autoimmune multi-organ syndrome (PAMS) is a rare clinical condition characterized by variable and heterogeneous phenotypes in the presence of neoplasias which largely depend on activation humoral cellular immune responses. Clinically, these patients present with spectrum antibody-driven pemphigus-like lesions to graft-vs.-host-disease-like exanthemas lichenoid inflammatory infiltrate skin. PAMS occasionally associated thymoma, altered surveillance eventually...
As neuroendocrine tumors (NETs) often present as metastatic lesions, immunohistochemical assignment to a site of origin is one the most important tasks in their pathologic assessment. Because fraction NETs eludes typical expression profiles primary localization, additional sensitive and specific markers are required improve diagnostic certainty. We investigated transcription factor Pituitary Homeobox 2 (PITX2) large-scale cohort 909 NET 248 carcinomas (NEC) according immunoreactive score...
Abstract Background Double-lumen tube (DLT) intubation is necessary for thoracic surgery and other operations with the need lung separation. However, DLT insertion complex might result in airway trauma. A new videolaryngoscopy (GVL) a thin blade improve time reduce complexity as well iatrogenic complications compared to conventional direct laryngoscopy (DL) intubation. Methods randomised, controlled trial was conducted 70 patients undergoing elective using Primary endpoint successful The...
Background Our pilot study describes our initial experience to do a laser resection of lung metastases under video-assisted thoracoscopic control via minithoracotomy. With this approach, if needed, mediastinal lymphadenectomy is also possible. Methods In study, 15 patients (11 men and 4 women, mean age: 60 years) with resectable different solid primary tumors (colorectal cancer in seven patients, melanoma three renal cell carcinoma two one each oropharyngeal cancer, breast seminoma) were...
Abstract Introduction Pulmonary segmentectomy, when combined with hilar and mediastinal lymphadenectomy, is currently considered the gold standard treatment for early-stage lung tumors (NSCLC) smaller than 2 cm in diameter. The preoperative planning segmentectomies usually includes a contrast-enhanced CT 2D reconstructions (axial, coronary, sagittal). Recent technological advances allow 3D (volume rendering) of scans, intended to improve surgeon’s understanding segmental anatomy. study aims...
The pulmonary residence time of inhaled glucocorticoids as well their rate and extend absorption into systemic circulation are important facets efficacy-safety profile. We evaluated a novel approach to elucidate the an glucocorticoid. Our objective was monitor compare combined process drug particle dissolution, pro-drug activation course initial distribution from human lung tissue plasma for two different glucocorticoid formulations. chose beclomethasone dipropionate (BDP) delivered by...
Abstract Purpose: MAGE-A gene expression in humans is mostly restricted to tumor cells, and the role of transcripts peptides as diagnostic markers therapeutic targets currently under investigation. Thus far, clinical relevance marker for disseminated cells bone marrow patients with operable lung cancer without overt metastases still unclear. Experimental Design: Preoperative aspirates from 50 consecutive non–small-cell free distant (i.e., pT1-4 pN0-2 M0 R0) were admitted study. Each sample...
This study reports the results of an international expert consensus process evaluating assessment intraoperative air leaks (IAL) and treatment postoperative prolonged (PAL) utilizing a Delphi process, with aim helping standardization improving practice.A panel 45 questions was developed submitted to working group experts in minimally invasive lung cancer surgery. Modified methodology used review responses, including 3 rounds voting. The defined priori as >50% agreement among experts....
Background. Lateral approaches to the spine have gained increased popularity due enabling minimally invasive access spine, less blood loss, decreased operative time, and postoperative pain. The objective of study was analyze use intraoperative computed tomography with navigation implementation augmented reality in facilitating a lateral approach spine. Methods. We prospectively analyzed all patients who underwent surgery from September 2016 January 2021 using CT applying 32-slice movable...
The mammary tumor milk agent was not demonstrable in the aqueous extracts of 4 carcinomata induced by methylcholanthrene female mice which were susceptible to development spontaneous carcinoma but did possess before treatment because foster-nursing. action carcinogen thus dependent upon presence a agent.
<b><i>Background:</i></b> Robust clinical evidence on the efficacy and safety of endoscopic lung volume reduction (ELVR) with one-way valves in patients severe emphysema chronic hypercapnic respiratory failure is lacking. <b><i>Objective:</i></b> The aim this study was to compare patient characteristics, outcome measures, incidences adverse events between COPD undergoing ELVR either a partial pressure carbon dioxide...
Lower respiratory tract infections caused by Streptococcus pneumoniae (Spn) are a leading cause of death globally. Here we investigate the bronchial epithelial cellular response to Spn infection on transcriptomic, proteomic and metabolic level. We found NAD+ salvage pathway be dysregulated upon in cell line model, primary human lung tissue vivo rodents, reduced production NAD+. Knockdown enzymes (NAMPT, NMNAT1) increased bacterial replication. treatment inhibited its growth while other...