A5044372334- Glioma Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Advanced MRI Techniques and Applications
- Medical Image Segmentation Techniques
- Advanced Neuroimaging Techniques and Applications
- Epilepsy research and treatment
- Neurological disorders and treatments
- Medical Imaging Techniques and Applications
- Pharmacological Effects and Toxicity Studies
- Surgical Simulation and Training
- Spine and Intervertebral Disc Pathology
- Medical Imaging and Analysis
- Meningioma and schwannoma management
- Radiomics and Machine Learning in Medical Imaging
- COVID-19 and healthcare impacts
- Pituitary Gland Disorders and Treatments
- Cell Adhesion Molecules Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Anatomy and Medical Technology
- Advanced Neural Network Applications
- Augmented Reality Applications
- Intracranial Aneurysms: Treatment and Complications
- Radiation Dose and Imaging
- Fetal and Pediatric Neurological Disorders
- Protease and Inhibitor Mechanisms
Philipps University of Marburg
2016-2025
Helios Dr. Horst Schmidt Kliniken Wiesbaden
2020-2025
Brain (Germany)
2021
Universitätsklinikum Gießen und Marburg
2018-2020
Marquette General Hospital
2017
Tongji Hospital
2015
University of Freiburg
2015
King's College London
2015
Alverno College
2012
Medical College of Wisconsin
2012
Summary Objective To provide first data on inpatient costs and cost‐driving factors due to nonrefractory status epilepticus ( NSE ), refractory RSE super‐refractory SRSE ). Methods In 2013 2014, all adult patients treated SE ) at the university hospitals in Frankfurt, Greifswald, Marburg were analyzed for healthcare utilization. Results We evaluated 341 admissions 316 (65.7 ± [standard deviation]18.2 years; 135 male) . Mean of hospital treatment €14,946 (median €5,278, range €776–€152,911,...
Study Design: A prospective, case-based, observational study. Objectives: To investigate how microscope-based augmented reality (AR) support can be utilized in various types of spine surgery. Methods: In 42 spinal procedures (12 intra- and 8 extradural tumors, 7 other intradural lesions, 11 degenerative cases, 2 infections, deformities) AR was implemented using operating microscope head-up displays (HUDs). Intraoperative low-dose computed tomography used for automatic registration. Nonlinear...
Low registration errors are an important prerequisite for reliable navigation, independent of its use in cranial or spinal surgery. Regardless whether navigation is used trajectory alignment biopsy implant procedures, sophisticated augmented reality applications, all depend on a correct patient space and image space. In contrast to fiducial, landmark, surface matching-based registration, the application intraoperative imaging allows user-independent automatic which less error prone. The...
Despite multimodal treatment, glioblastoma (GBM) therapy with temozolomide (TMZ) remains inefficient due to chemoresistance. Matrix metalloproteinase (MMP) and a disintegrin metalloprotease (ADAM), increased in GBM, could contribute chemoresistance TMZ-induced recurrence of glioblastoma. TMZ inducibility metalloproteases was determined GBM cell lines, primary cells, tissues from recurrent GBM. sensitivity invasiveness cells were assessed the presence inhibitors batimastat (BB-94) marimastat...
Due to poor prognosis of glioblastoma (GBM), there is an urgent need develop new therapeutic strategies. Besides eliminating GBM tumor cells and stem cells, a novel approach aims target Glioma-associated microglia/macrophages (GAMs). We investigated the molecular profile GAMs correlated with patient by exploiting M1/M2-like polarization markers in cohort 20 patients. Using quantitative PCR (qPCR), CXCL10 (M1) CCL13 (M2) were validated human macrophages applied global analysis tissue....
Metastatic breast cancer affects long-term survival and is a major cause of death for women worldwide. The Metalloprotease-Disintegrin ADAM8 promotes development brain metastasis in mouse model. Here, abundant expression was detected primary human tumors associated metastases. To investigate the function metastasis, MB-231 cells with knockdown (MB-231_shA8) scramble control (MB-231_shCtrl) were analyzed their capability to develop In vitro, formation metastatic complexes hanging drops...
BackgroundThe need for imaging-guided optimization of Deep Brain Stimulation (DBS) parameters is increasing with recent developments sophisticated lead designs offering highly individualized, but time-consuming and complex programming.ObjectiveThe objective this study was to compare changes in motor symptoms Parkinson's Disease (PD) the corresponding volume electrostatic field (VEsF) achieved by DBS programming using GUIDE XT™, a commercially available software visualization leads within...
Background: The aim of surgery for skull base meningiomas is maximal resection with minimal damage to the involved cranial nerves and cerebral vessels; thus, implementation technologies improved orientation in surgical field, such as neuronavigation augmented reality (AR), interest. Methods: Included study were 39 consecutive patients (13 male, 26 female, mean age 64.08 ± 13.5 years) who underwent using microscope-based AR automatic patient registration intraoperative computed tomography...
Glioblastoma (GBM) as the most common and aggressive brain tumor is characterized by genetic heterogeneity, invasiveness, radio-/chemoresistance, occurrence of GBM stem-like cells. The metalloprotease-disintegrin ADAM8 highly expressed in immune cells correlates with poor survival. In GBM, affects intracellular kinase signaling increases expression levels osteopontin/SPP1 matrix metalloproteinase 9 (MMP9) an unknown mechanism. Here we explored whether microRNA (miRNA) could be regulators...
Background: Pharmacoresistant epilepsy affects approximately one-third of all patients, and resective surgery may offer favorable outcomes for carefully selected patients with focal epilepsy. The accurate identification the epileptogenic zone (EZ) is essential successful surgery, particularly in cases where non-invasive diagnostics are inconclusive. Invasive stereoelectroencephalography (SEEG) a reliable approach to localizing EZ, especially MRI-negative cases. Methods: This retrospective...
Invasion of tumor cells critically depends on cell‐cell or cell‐extracellular matrix interactions. Enzymes capable modulating these interactions belong to the proteinase families ADAM (a disintegrin and metalloprotease) MMP (matrix proteins. Our objective is examine their expression levels evaluate relationship between cavernous sinus invasion in pituitary adenomas. Tissue samples from 35 patients with adenomas were analyzed. Quantitative real‐time polymerase chain reaction (qPCR) was...
About 95% of patients with Glioblastoma (GBM) show tumor relapse, leaving them limited therapeutic options as recurrent tumors are most often resistant to the first line chemotherapy standard Temozolomide (TMZ). To identify molecular pathways involved in TMZ resistance, primary GBM Stem-like Cells (GSCs) were isolated, characterized, and selected for resistance vitro. Subsequently, RNA sequencing analysis was performed revealed a total 49 differentially expressed genes (|log2-fold change|...
Abstract Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer with a median survival only 15 months. To complement standard treatments including surgery, radiation and chemotherapy, it essential to understand contribution GBM tumor microenvironment. Brain macrophages microglia particularly contribute angiogenesis, major hallmark GBM. ADAM8 , metalloprotease-disintegrin strongly expressed in cells associated immune GBMs, related angiogenesis correlates poor clinical...
Surgical treatment of spondylodiscitis allows for rapid mobilization and shortens hospital stays, which makes surgical the first-line therapy. We aim to describe our experiences with operative on determine parameters that are important in prediction outcomes. A retrospective review identified 237 patients who were operatively treated institution between January 2010 December 2018. Clinical data collected through electronic records relevant imaging. In all cases, contrast-enhancing MRI from...