A5016638177- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Airway Management and Intubation Techniques
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inhalation and Respiratory Drug Delivery
- Cardiac Arrest and Resuscitation
- Thermal Regulation in Medicine
- Intensive Care Unit Cognitive Disorders
- Tracheal and airway disorders
- Cellular Mechanics and Interactions
- Anesthesia and Sedative Agents
- Phonocardiography and Auscultation Techniques
- Heart Rate Variability and Autonomic Control
- Mechanical Circulatory Support Devices
- Hemodynamic Monitoring and Therapy
- Neuroscience of respiration and sleep
- Criminal Law and Policy
- Non-Invasive Vital Sign Monitoring
- Nosocomial Infections in ICU
- Congenital Diaphragmatic Hernia Studies
- Biosensors and Analytical Detection
- Gaze Tracking and Assistive Technology
- 3D Printing in Biomedical Research
- Gastroesophageal reflux and treatments
- Visual perception and processing mechanisms
University of Freiburg
2016-2025
University Medical Center Freiburg
2016-2025
Universität Hamburg
2025
University Medical Center Hamburg-Eppendorf
2025
University Medical Center of the Johannes Gutenberg University Mainz
2025
Johannes Gutenberg University Mainz
2025
Medizinische Hochschule Brandenburg Theodor Fontane
2025
Justus-Liebig-Universität Gießen
2023
Giessen School of Theology
2023
Johannes Kepler University of Linz
2015-2021
Exhaled breath contains a large amount of biochemical and physiological information concerning one's health provides an alternative route to noninvasive medical diagnosis diseases. In the case lung diseases, hydrogen peroxide (H
It is not clear whether the mechanical properties of respiratory system assessed under dynamic condition ventilation are equivalent to those static conditions. We hypothesized that analyses and mechanics provide different information in acute failure.Prospective multiple-center study.Intensive care units eight German university hospitals.A total 28 patients with lung injury distress syndrome.None.Dynamic were determined during ongoing an incremental positive end-expiratory pressure (PEEP)...
A closed-loop system (AUTOPILOT-BT) for the control of mechanical ventilation was designed to: 1) autonomously achieve goals specified by clinician, 2) optimize ventilator settings with respect to underlying disease and 3) automatically a
Abstract Personalized antibiotherapy ensures that the antibiotic concentration remains in optimal therapeutic window to maximize efficacy, minimize side effects, and avoid emergence of drug resistance due insufficient dosing. However, such individualized schemes need frequent sampling tailor blood concentrations. To optimally integrate monitoring (TDM) into clinical workflow, levels can either be measured using point‐of‐care testing (POCT), or rely on noninvasive sampling. Here, a versatile...
Chronic neck pain is a major public health burden with only limited evidence for the effectiveness of complementary therapies. This study aimed to test efficacy cupping massage in patients pain.Patients chronic non-specific were randomly assigned or wait list control. The intervention group received 5 massages on twice-weekly basis while control continued their usual treatments. primary outcome measure was intensity (0-100 mm visual analogue scale (VAS)) after 3 weeks. Secondary outcomes...
BACKGROUND In contrast to conventional mandatory ventilation, a new ventilation mode, expiratory assistance (EVA), linearises the tracheal pressure decline. OBJECTIVE We hypothesised that due recruiting effect, linearised expiration oxygenates better than volume controlled (VCV). compared EVA with VCV mode regard gas exchange, volumes and pressures lung aeration in model of peri-operative healthy pigs. DESIGN Controlled interventional trial. SETTING Animal operating facility at university...
Objectives: Lung-protective ventilation for acute respiratory distress syndrome aims providing sufficient oxygenation and carbon dioxide clearance, while limiting the harmful effects of mechanical ventilation. “Flow-controlled ventilation”, a constant expiratory flow, has been suggested as new lung-protective strategy. The aim this study was to test whether flow-controlled attenuates lung injury in an animal model syndrome. Design: Preclinical, randomized controlled study. Setting: Animal...
Background Flow‐controlled ventilation (FCV) is a new mode that provides constant inspiratory and expiratory flow. FCV was shown to improve gas exchange lung recruitment in porcine models of healthy injured ventilated lungs. The primary aim our study verify the influences on exchange, respiratory mechanics haemodynamic variables mechanically lung‐healthy patients. Methods After obtaining ethical approval informed consent, we measured arterial blood gases, during volume‐controlled (VCV) 20...
Abstract Background In obese patients, high closing capacity and low functional residual increase the risk for expiratory alveolar collapse. Constant flow, as provided by new flow-controlled ventilation (FCV) mode, was shown to improve lung recruitment. We hypothesized that aeration respiratory mechanics in patients during FCV. Methods compared FCV volume-controlled (VCV) 23 a randomized crossover setting. Starting with baseline measurements, settings were kept identical except mode related...
The mechanical forces acting on lung parenchyma during (mechanical) ventilation and its (patho)physiological consequences are currently under intense scrutiny. Several in vivo cell culture models have been developed to study the pulmonary responses stretch. While providing extremely useful information, these do also suffer from limitations being either too complex for detailed or mechanistic studies, devoid of full complexity present (e.g., different types interstitial matrix). Therefore it...
Objective Non-invasive high-frequency oscillatory ventilation (nHFOV) has recently been described as a novel mode of respiratory support for premature infants. This study was designed to determine whether nHFOV decreases CO 2 partial pressure (pCO ) in infants more effectively than non-invasive continuous positive airway (nCPAP). Design Non-blinded prospective randomised controlled cross-over study. Setting University Medical Center tertiary neonatal intensive care unit. Patients 26 27±2...
Flow-controlled ventilation (FCV) is a new mechanical mode that maintains constant flow during inspiration and expiration with standard tidal volumes via cuffed narrow-bore endotracheal tubes. Originating in manually operated 'expiratory assistance', FCV extends this technique by automatic control of airway flow, monitoring intratracheal pressure peak inspiratory end-expiratory pressure. has not yet been described clinical study.The aim study was to provide an initial assessment mechanically...
Abstract We investigated lung aeration during preoxygenation, mask ventilation, ventilation via endotracheal tube, and the two apnoeic phases in-between. Using electrical impedance tomography we assessed global inhomogeneity, ventral-to-dorsal distribution, area of ventilated end-expiratory volume loss. Global inhomogeneity was increased after (non-obese: 25%, obese: 66%, p<0.005 for both) re-improved with first breaths mechanical (non-obese) or only (obese). Ventral 52%, 36%) second...
<title>Abstract</title> With increasing focus on neurodevelopment in children with congenital heart disease (CHD), early predictive markers are crucial to intervene and improve neurodevelopmental outcome. As postoperative delirium (PD) is known have a long-term impact neurocognitive function adults, investigations into the prevalence identification of modifiable risk factors PD offer new perspectives. We conducted retrospective, single-centre study screening for using Cornell Assessment...
The abducens nerve (AN), our sixth cranial nerve, is responsible for the innervation of lateral rectus muscle eye. a vulnerable structure at skull base with its long intracranial course and complex topographic relationships. AN anatomy in petroclival region, where passes from posterior to middle fossa, great interest neurosurgical procedures. Despite detailed studies past 150 years, there need more recent data on macroscopical microscopical aspects well defined populations. We investigated...
In the clinical situation and in most research work, analysis of respiratory system mechanics is limited to estimation single-value compliances during static or quasi-static conditions. contrast, our SLICE method analyses intratidal nonlinearity under dynamic conditions mechanical ventilation by calculating compliance resistance for six conjoined volume portions (slices) pressure-volume loop multiple linear regression analysis. With gliding-SLICE we present a new approach determine...