Chris Brew‐Graves
A5002074685- Prostate Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Urinary and Genital Oncology Studies
- Advances in Oncology and Radiotherapy
- Urologic and reproductive health conditions
- Breast Lesions and Carcinomas
- Urological Disorders and Treatments
- Lung Cancer Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Breast Implant and Reconstruction
- Colorectal Cancer Treatments and Studies
- Pediatric Urology and Nephrology Studies
- Urinary Bladder and Prostate Research
- Renal cell carcinoma treatment
- Pelvic floor disorders treatments
- Ethics in Clinical Research
- Cancer Diagnosis and Treatment
- Urinary Tract Infections Management
- Peripheral Nerve Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Sexual function and dysfunction studies
University College London
2016-2025
Faculty (United Kingdom)
2020-2023
Royal Free London NHS Foundation Trust
2023
Royal London Hospital
2012-2023
Healthcare Quality Improvement Partnership
2023
Whipps Cross University Hospital
2023
Barts Health NHS Trust
2023
Mayo Clinic
2023
Age UK
2020
University College Hospital
2012-2018
Multiparametric magnetic resonance imaging (MRI), with or without targeted biopsy, is an alternative to standard transrectal ultrasonography-guided biopsy for prostate-cancer detection in men a raised prostate-specific antigen level who have not undergone biopsy. However, comparative evidence limited.In multicenter, randomized, noninferiority trial, we assigned clinical suspicion of prostate cancer had previously undergo MRI, Men the MRI-targeted group underwent (without cores) if MRI was...
Abstract Objective To determine whether risk adapted intraoperative radiotherapy, delivered as a single dose during lumpectomy, can effectively replace postoperative whole breast external beam radiotherapy for early cancer. Design Prospective, open label, randomised controlled clinical trial. Setting 32 centres in 10 countries the United Kingdom, Europe, Australia, States, and Canada. Participants 2298 women aged 45 years older with invasive ductal carcinoma up to 3.5 cm size, cN0-N1,...
Robot-assisted radical cystectomy is being performed with increasing frequency, but it unclear whether total intracorporeal surgery improves recovery compared open for bladder cancer.
Lung metastasectomy in the treatment of advanced colorectal cancer has been widely adopted without good evidence survival or palliative benefit. We aimed to test its effectiveness a randomised controlled trial (RCT).
Multiparametric magnetic resonance imaging (mpMRI)-targeted prostate biopsies can improve detection of clinically significant cancer and decrease the overdetection insignificant cancers. It is unknown whether visual-registration targeting sufficient or augmentation with image-fusion software needed.
<h3>Importance</h3> Conventional adjuvant radiotherapy for breast cancer given daily several weeks is onerous and expensive. Some patients may be obliged to choose a mastectomy instead, some forgo altogether. We proposed clinical trial test whether could safely limited the tumor bed. <h3>Objective</h3> To determine delayed second-procedure targeted intraoperative (TARGIT-IORT) noninferior whole-breast external beam (EBRT) in terms of local control. <h3>Design, Setting, Participants</h3> In...
Introduction Bladder cancer (BC) is a common malignancy and one of the most expensive to manage. Radical cystectomy (RC) with pelvic lymphadenectomy gold standard treatment for high-risk BC. Reductions in morbidity mortality from RC may be achieved through robot-assisted (RARC). Prospective comparisons between open (ORC) RARC have been limited by sample size, use extracorporeal reconstruction outcomes important ORC. Conversely, while gaining popularity, there little evidence suggest it...
Abstract Aim We wanted to examine survival in patients with resected colorectal cancer (CRC) whose lung metastases are or not resected. Methods Teams participating the study of Pulmonary Metastasectomy Colorectal Cancer (PulMiCC) identified potential candidates for metastasectomy and invited their consent join Stage 1. Baseline data related CRC fitness surgery were collected. Eligible randomization PulMiCC randomized controlled trial (Stage 2). Sites provided case report forms non‐randomized...
Introduction Prostate MRI is a well-established tool for the diagnostic work-up men with suspected prostate cancer (PCa). Current recommendations advocate use of multiparametric (mpMRI), which composed three sequences: T2-weighted sequence (T2W), diffusion-weighted (DWI) and dynamic contrast-enhanced (DCE). Prior studies suggest that biparametric (bpMRI) approach, omitting DCE sequences, may not compromise clinically significant detection, though there are limitations to these studies, it...
Background High variability in prostate MRI quality might reduce accuracy cancer detection. Purpose To prospectively evaluate the of scanners taking part control phase global PRIME (Prostate Imaging Using ± Contrast Enhancement) trial using Prostate Quality (PI-QUAL) standardized scoring system, give recommendations on how to improve protocols, and establish whether could be improved by these recommendations. Materials Methods In prospective clinical (PRIME), for each scanner, centers...
Radical prostatectomy (RP) is an established treatment for localised prostate cancer that can have a significant impact on urinary and sexual function, with recovery over time. Our aim was to describe functional in the first year after RP, reporting descriptive outcomes alongside validated patient-reported outcome measure scores (Expanded Prostate Cancer Index Composite, EPIC-26).
Computerized tomography urogram is recommended when investigating patients with hematuria. We determined the incidence of urinary tract cancer and compared diagnostic accuracy computerized to that renal bladder ultrasound for identifying cancer.The DETECT (Detecting Bladder Cancer Using UroMark Test) I study a prospective observational recruiting 18 years old or older following presentation macroscopic microscopic hematuria at total 40 hospitals. All underwent cystoscopy upper imaging...
Background Based on our laboratory work and clinical trials we hypothesised that radiotherapy after lumpectomy for breast cancer could be restricted to the tumour bed. In collaboration with industry developed a new device surgical operation delivering single-dose radiation bed – tissues at highest risk of local recurrence. We named it TARGeted Intraoperative radioTherapy (TARGIT). From 1998 confirmed its feasibility safety in pilot studies. Objective To compare TARGIT within risk-adapted...
The TARGIT-A trial reported risk-adapted targeted intraoperative radiotherapy (TARGIT-IORT) during lumpectomy for breast cancer to be as effective whole-breast external beam (EBRT). Here, we present further detailed analyses.In total, 2298 women (≥45 years, invasive ductal carcinoma ≤3.5 cm, cN0-N1) were randomised. We investigated the impact of tumour size, grade, ER, PgR, HER2 and lymph node status on local recurrence-free survival, recurrence distant relapse mortality. analysed predictive...
The COVID-19 pandemic has posed daunting challenges when conducting clinical research. Adopting new technologies such as remote electronic consent (e-Consent) can help overcome them. However, guidelines for e-Consent implementation in ongoing trials are currently lacking. NeuroSAFE PROOF trial is a randomized evaluating the role of frozen section analysis during RARP prostate cancer. In response to crisis, recruitment was halted, and solution designed. aim this paper describe process...
Importance The value to payers of robot-assisted radical cystectomy with intracorporeal urinary diversion (iRARC) when compared open (ORC) for patients bladder cancer is unclear. Objectives To compare the cost-effectiveness iRARC that ORC. Design, Setting, and Participants This economic evaluation used individual patient data from a randomized clinical trial at 9 surgical centers in United Kingdom. Patients nonmetastatic were recruited March 20, 2017, January 29, 2020. analysis health...
Introduction Children having surgery, and their parents, commonly have anxiety in the preoperative period, this may impact longer-term health quality of life. Psychological preparation can be expensive time-consuming, type effectiveness preparatory interventions are variable. The aim randomised controlled trial (RCT) is to evaluate clinical a smartphone psychological application with virtual reality (VR) capability (the ‘Little Journey app’ (LJ)), at reducing its sequelae children carers....
Sparing the periprostatic neurovascular bundles during robot-assisted radical prostatectomy (RARP) improves postoperative erectile function and early urinary continence recovery. The NeuroSAFE technique, a standardised frozen section analysis, enables accurate real-time detection of positive surgical margins nerve-sparing, increasing likelihood successful nerve preservation. However, impact technique on patient outcomes remains uncertain. We aimed to assess effect NeuroSAFE-guided RARP...
Objectives To report on the methods, peri‐operative outcomes and histopathological concordance between frozen final section from NeuroSAFE PROOF feasibility study (NCT03317990). Patients Methods Between May 2018 March 2019, 49 patients at two UK centres underwent robot‐assisted radical prostatectomy (RARP). Twenty‐five patient were randomized to RARP (intervention arm) 24 standard (control arm). Frozen was compared paraffin margin assessment in 25 arm. Operation timings complications...
Objectives To determine the diagnostic accuracy of urinary cytology to diagnose bladder cancer and upper tract urothelial ( UTUC ) as well outcome patients with a positive urine normal haematuria investigations in multicentre prospective observational study investigated for haematuria. Patient methods The DETECT I (clinicaltrials.gov NCT 02676180) recruited presenting following referral secondary case at 40 hospitals. All had cystoscopy imaging (renal ultrasound [ RBUS ] and/ or CT urogram...