A5024909099- Erythropoietin and Anemia Treatment
- Prostate Cancer Diagnosis and Treatment
- Parathyroid Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Vitamin D Research Studies
- Dialysis and Renal Disease Management
- Prostate Cancer Treatment and Research
- Sexual function and dysfunction studies
- Microscopic Colitis
- Chronic Kidney Disease and Diabetes
- Radiomics and Machine Learning in Medical Imaging
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Inflammatory Bowel Disease
- Diabetes Treatment and Management
- Ethics in Clinical Research
- Patient-Provider Communication in Healthcare
- Eicosanoids and Hypertension Pharmacology
- Nutrition, Genetics, and Disease
- Venous Thromboembolism Diagnosis and Management
- Systemic Lupus Erythematosus Research
- Blood Coagulation and Thrombosis Mechanisms
- Blood transfusion and management
- Muscle and Compartmental Disorders
- Advanced MRI Techniques and Applications
University College London
2014-2023
Royal London Hospital
2023
Whipps Cross University Hospital
2023
Barts Health NHS Trust
2023
Royal Free London NHS Foundation Trust
2023
Mayo Clinic
2023
MRC Prion Unit
2022
Steno Diabetes Centers
2021
University of Copenhagen
2021
MRC Clinical Trials Unit at UCL
2014-2016
Rivaroxaban is established for the treatment and secondary prevention of venous thromboembolism, but whether it useful in patients with antiphospholipid syndrome uncertain.This randomised, controlled, open-label, phase 2/3, non-inferiority trial, done two UK hospitals, included who were taking warfarin previous a target international normalised ratio 2·5. Patients randomly assigned 1:1 to continue or receive 20 mg oral rivaroxaban daily. Randomisation was centrally, stratified by centre...
Mortality rates from chronic kidney disease (CKD) have increased in the last decade. In this pre-specified analysis of DAPA-CKD trial, we determined effects dapagliflozin on cardiovascular and non-cardiovascular causes death.DAPA-CKD was an international, randomized, placebo-controlled trial with a median 2.4 years follow-up. Eligible participants were adult patients CKD, defined as urinary albumin-to-creatinine ratio (UACR) 200-5000 mg/g estimated glomerular filtration rate (eGFR) 25-75...
This pre-specified analysis of DAPA-CKD assessed the impact sodium-glucose cotransporter 2 inhibition on abrupt declines in kidney function high-risk patients based having chronic disease (CKD) and substantial albuminuria. was a randomized, double-blind, placebo-controlled trial that had median follow-up 2.4 years. Adults with CKD (urinary albumin-to-creatinine ratio 200–5000 mg/g estimated glomerular filtration rate 25–75 mL/min/1.73m2) were randomized to dapagliflozin 10 mg/day matched...
Introduction Prostate MRI is a well-established tool for the diagnostic work-up men with suspected prostate cancer (PCa). Current recommendations advocate use of multiparametric (mpMRI), which composed three sequences: T2-weighted sequence (T2W), diffusion-weighted (DWI) and dynamic contrast-enhanced (DCE). Prior studies suggest that biparametric (bpMRI) approach, omitting DCE sequences, may not compromise clinically significant detection, though there are limitations to these studies, it...
Background High variability in prostate MRI quality might reduce accuracy cancer detection. Purpose To prospectively evaluate the of scanners taking part control phase global PRIME (Prostate Imaging Using ± Contrast Enhancement) trial using Prostate Quality (PI-QUAL) standardized scoring system, give recommendations on how to improve protocols, and establish whether could be improved by these recommendations. Materials Methods In prospective clinical (PRIME), for each scanner, centers...
This study examined the efficacy of C.E.R.A., a continuous erythropoietin receptor activator, for correcting anemia in patients who had chronic kidney disease (CKD) and were not on dialysis.In this open-label, randomized, parallel-group, Phase III study, 324 adult with CKD dialysis nor receiving treatment erythropoiesis-stimulating agents (ESAs) randomly assigned (1:1) to receive subcutaneous C.E.R.A. once every 2 wk or darbepoetin alfa weekly during an 18-wk correction period 10-wk...
Introduction The current mainstay of the treatment thrombotic antiphospholipid syndrome (APS) is long-term anticoagulation with vitamin K antagonists (VKAs) such as warfarin. Non-VKA oral anticoagulants (NOACs), which include rivaroxaban, have been shown to be effective and safe compared warfarin for venous thromboembolism (VTE) in major phase III prospective, randomized controlled trials (RCTs), but results may not directly generalizable patients APS. Aims primary aim demonstrate, APS...
The COVID-19 pandemic has posed daunting challenges when conducting clinical research. Adopting new technologies such as remote electronic consent (e-Consent) can help overcome them. However, guidelines for e-Consent implementation in ongoing trials are currently lacking. NeuroSAFE PROOF trial is a randomized evaluating the role of frozen section analysis during RARP prostate cancer. In response to crisis, recruitment was halted, and solution designed. aim this paper describe process...
Crohn's disease (CD) is a lifelong, relapsing and remitting inflammatory condition of the intestine. Medical imaging crucial for diagnosis, phenotyping, activity assessment detecting complications. Diverse small bowel tests are available but standard algorithm deployment lacking. Many hospitals employ that impart ionising radiation, particular concern to this young patient population. Magnetic resonance enterography (MRE) ultrasound (USS) attractive options, as they do not use radiation....
Abstract Background Previous studies suggest that the beneficial health effects of a diet rich in whole grains could be result individual fibres found grain. The present study aimed to investigate influence high either wheat fibre (as an example insoluble fibre) or inulin (a nondigestible carbohydrate) on markers cardiovascular disease. Methods Ten male participants classified as at higher risk disease [mean (SD) body mass index 30.2 (3) kg m −2 , mean waist circumference 106.4 (7) cm, age...
The response of the parathyroids to an infusion calcium has been studied in patients with secondary hyperparathyroidism due either vitamin D deficiency or chronic renal failure. Two specific homologous immunoradiometric assays for human parathyroid hormone (PTH) have used assess response, one amino‐terminus (N‐PTH), other carboxy‐terminus (C‐PTH) molecule. In both deficient and uraemic patients, a 4 mg/kg/h generally h, suppression N‐PTH was similar, falling around 20–30% initial value....
Summary The National Cancer Imaging Translational Accelerator (NCITA) is creating a UK national coordinated infrastructure for accelerated translation of imaging biomarkers clinical use. Through the development standardised protocols, data integration tools and ongoing training programmes, NCITA provides unique scalable biomarker qualification using multicentre studies.
Abstract Background Robotic radical prostatectomy (RARP) is a first-line curative treatment option for localized prostate cancer. Postoperative erectile dysfunction and urinary incontinence are common associated adverse side effects that can negatively impact patients’ quality of life. Preserving the lateral neurovascular bundles (NS) during RARP improves functional outcomes. However, selecting men NS may be difficult when there concern about incurring in positive surgical margin (PSM) which...
Skeletal muscle metabolism during exercise was compared in 5 patients with end-stage renal disease (ESRD) and 8 healthy controls, using a noninvasive technique, 31P magnetic resonance spectroscopy (MRS). After 3 months of anaemia correction recombinant human erythropoietin (rHuEPO) these were re-evaluated. Maximal power achieved by the ESRD dynamic wrist flexion test 33% lower (p < 0.05) than controls. Similarly group, at onset metabolic acidosis (the intracellular threshold) 29% less The...
<h3>Introduction</h3> Circulating prostaglandin E<sub>2</sub> levels are elevated in acutely decompensated cirrhosis and have been shown to contribute immune suppression. Albumin binds inactivates this hormone. Human albumin solution could thus be repurposed as an restorative drug these patients. This feasibility study aims determine whether it is possible safe restore serum >30 g/L maintain at level patients admitted with acute using repeated 20% human infusions according daily levels....
Twenty-three patients with end-stage renal failure on maintenance haemodialysis were treated 1, 25-dihydroxy vitamin D3 or 24–25-dihydroxy for 3–32 months (total 232 patient months). Treatment was marked by symptomatic, biochemical and histological improvements in the majority of patients. In constrast, treatment 24, produced no such developed severe symptomatic bone disease. Successful transplantation resulted rapid improvement symptoms, biochemistry histology nine 10 irrespective whether...
A study was conducted evaluating the response of serum parathyroid hormone to acute hypercalcaemia and long term administration 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in patients receiving maintenance haemodialysis. During infusion elemental calcium 4 mg/kg/h over four hours 12 not vitamin D concentration amino terminal fell by 31-96% (mean 74.8 (SD 17.6)%) while that carboxy changed little. There a strong inverse correlation between baseline percentage fall during (r = 0.88; p less than...
Validated patient-reported outcome measures (PROMs) have an important role in clinical practice and research studies. The outcomes may be used for patient counselling, clinician decision-making disease or treatment monitoring. Critically, PROMs are comparison of efficacy approaches However, PROMS remain under-utilised research. It is not uncommon studies to clinician-led; thus, prioritisation deemed more the can lead omission PROMS. Further challenges clinicians exist identifying relevant...
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