A5069535975- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Urologic and reproductive health conditions
- Urinary and Genital Oncology Studies
- Genital Health and Disease
- Colorectal Cancer Screening and Detection
- AI in cancer detection
- Renal cell carcinoma treatment
- Autopsy Techniques and Outcomes
- Molecular Biology Techniques and Applications
- Urological Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Cancer, Lipids, and Metabolism
- Global Cancer Incidence and Screening
- Infectious Diseases and Mycology
- CNS Lymphoma Diagnosis and Treatment
- Clinical practice guidelines implementation
- Advanced Radiotherapy Techniques
- Cancer, Hypoxia, and Metabolism
- Renal and Vascular Pathologies
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Research and Treatments
- Artificial Intelligence in Healthcare and Education
- Oral Health Pathology and Treatment
North Bristol NHS Trust
2014-2025
Southmead Hospital
2014-2024
National Health Service
2024
Royal Bournemouth Hospital
2024
Cleveland Clinic
2019
Velindre Cancer Centre
2016
University of Bristol
2016
Belfast Health and Social Care Trust
2012
Royal Devon & Exeter NHS Foundation Trust
2012
Bristol Royal Infirmary
1999-2008
The comparative effectiveness of treatments for prostate cancer that is detected by prostate-specific antigen (PSA) testing remains uncertain.
Between 1999 and 2009 in the United Kingdom, 82,429 men between 50 69 years of age received a prostate-specific antigen (PSA) test. Localized prostate cancer was diagnosed 2664 men. Of these men, 1643 were enrolled trial to evaluate effectiveness treatments, with 545 randomly assigned receive active monitoring, 553 undergo prostatectomy, radiotherapy.
BackgroundLong-term patient-reported outcomes are needed to inform treatment decisions for localized prostate cancer.MethodsPatient-reported of 1643 randomly assigned participants in the ProtecT (Prostate Testing Cancer and Treatment) trial were evaluated assess functional quality-of-life impacts prostatectomy, radiotherapy with neoadjuvant androgen deprivation, active monitoring. This article focuses on from 7 12 years using mixed effects linear logistic models.ResultsResponse rates...
Importance The Cluster Randomized Trial of PSA Testing for Prostate Cancer (CAP) reported no effect prostate-specific antigen (PSA) screening on prostate cancer mortality at a median 10-year follow-up (primary outcome), but the long-term effects remain unclear. Objective To evaluate single invitation cancer–specific 15-year compared with screening. Design, Setting, and Participants This secondary analysis CAP randomized clinical trial included men aged 50 to 69 years identified 573 primary...
The ProtecT trial reported intention-to-treat analysis of men with localised prostate cancer (PCa) randomly allocated to active monitoring (AM), radical prostatectomy, and external beam radiotherapy. To determine report outcomes according treatment received in randomised choice cohorts. This study focuses on secondary care. Men clinically at one nine UK centres were invited participate the comparing AM, Two cohorts included 1643 who agreed be randomised; 997 declined randomisation chose...
To investigate the functional and quality of life (QoL) outcomes treatments for localised prostate cancer inform treatment decision-making.Men aged 50-69 years diagnosed with by prostate-specific antigen testing biopsies at nine UK centres in Prostate Testing Cancer Treatment (ProtecT) trial were randomised to, or chose one of, three treatments. Of 2565 participants, 1135 men received active monitoring (AM), 750 a radical prostatectomy (RP), 603 external-beam radiotherapy (EBRT) concurrent...
To determine the accuracy of radiographic studies, ureteroscopy, biopsy, and cytology in predicting histopathology upper-tract transitional cell carcinoma (TCC).From 1998 to 2006, 46 lesions were diagnosed ureteroscopically underwent nephroureterectomy, 30 them subjected direct ureteroscopic inspection biopsy. Fresh samples delivered cytopathology laboratory histology prepared whenever visible tissue was present. Radiological, ureteroscopic, cytology, biopsy data compared actual grades...
The Gleason score is the most important prognostic marker for prostate cancer patients, but it suffers from significant observer variability. Artificial intelligence (AI) systems based on deep learning can achieve pathologist-level performance at grading. However, of such degrade in presence artifacts, foreign tissue, or other anomalies. Pathologists integrating their expertise with feedback an AI system could result a synergy that outperforms both individual pathologist and system. Despite...
Objective To test the hypothesis that baseline clinico‐pathological features of men with localized prostate cancer (PCa) included in ProtecT (Prostate Testing for Cancer and Treatment) trial who progressed ( n = 198) at a 10‐year median follow‐up were different from those stable disease 1409). Patients Methods We stratified study participants according to risk progression using clinical stage, pathological grade PSA level, Cox proportional hazard models. Results The findings showed 34% 505)...
To describe the histopathological features of a series patients with ketamine-related cystitis.Seventeen cystitis, who had undergone biopsy, were identified and reviewed. Twelve showed ulceration significant urothelial atypia. In 10 these, immunohistochemistry was performed; 9/10 high p53 immunoreactivity 7/10 moderate to levels Ki67 reactivity, but all negative for cytokeratin 20.Ketamine can lead reactive changes that mimic carcinoma in situ, long-term cancer risk remains unknown.
Background Prostate cancer is the most common among men in UK. Prostate-specific antigen testing followed by biopsy leads to overdetection, overtreatment as well undertreatment of disease. Evidence treatment effectiveness has lacked because paucity randomised controlled trials comparing conventional treatments. Objectives To evaluate treatments for localised prostate (active monitoring, radical prostatectomy and radiotherapy) aged 50–69 years. Design A prospective, multicentre...
Abstract The International Society of Urological Pathology (ISUP) hosts a reference image database supervised by experts with the purpose establishing an international standard in prostate cancer grading. Here, we aimed to identify areas grading difficulties and compare results those obtained from artificial intelligence system trained In series 87 needle biopsies cancers selected include problematic cases, failed reach 2/3 consensus 41.4% (36/87). Among non-consensus weighted kappa was 0.77...
Since radical prostatectomy is performed to cure prostate cancer, identification of markers enabling preoperative prediction relapse after essential counsel and select patients for adjuvant therapy. Aberrant p53, bcl-2, CD44 E-cadherin immunohistochemistry has been associated with aggressiveness in cancer. We assessed these biomarkers biopsy specimens as predictors biochemical relapse.A total 76 untreated clinically localized prostatic adenocarcinoma underwent prostatectomy. Preoperative...
Aims Despite efforts to standardise grading of prostate cancer, even among experts there is still a considerable variation in practices. In this study we describe the use Pathology Imagebase, novel reference image library, for setting an international standard cancer grading. Methods and results The International Society Urological ( ISUP ) recently launched database supervised by experts. A panel 24 pathology reviewed independently microphotographs 90 cases needle biopsies with cancer....
Early detection and treatment of asymptomatic men with advanced high-risk prostate cancer (PCa) may improve survival rates. To determine outcomes for diagnosed PCa following prostate-specific antigen (PSA) testing who were excluded from the ProtecT randomised trial. Mortality was compared 492 followed up a median 7.4 yr to contemporaneous cohort UK Anglia Cancer Network (ACN) matched subset ACN. PCa-specific all-cause mortality using Kaplan-Meier analysis Cox's proportional hazards...
Accurate cause of death assignment is crucial for prostate cancer epidemiology and trials reporting cancer-specific mortality outcomes. We compared certificate information with independent evaluation by an expert committee within a trial (2002–2015). Of 1236 deaths assessed, attributed 523 (42%) to cancer, agreeing in 1134 cases (92%, 95% CI: 90%, 93%). The sensitivity certificates identifying as classified the was 91% (95% 89%, 94%); specificity 92% 94%). Sensitivity were lower where...
Objectives To report on the methods, peri‐operative outcomes and histopathological concordance between frozen final section from NeuroSAFE PROOF feasibility study (NCT03317990). Patients Methods Between May 2018 March 2019, 49 patients at two UK centres underwent robot‐assisted radical prostatectomy (RARP). Twenty‐five patient were randomized to RARP (intervention arm) 24 standard (control arm). Frozen was compared paraffin margin assessment in 25 arm. Operation timings complications...
A hybrid-three tier system with low grade (LG), high grade- G2 (HG-G2), G3 (HG-G3) has been proposed in recognition of, and to help address, the clinical heterogeneity within WHO 2004/2022. We assessed interobserver reproducibility amongst international uropathologists using this three-tier approach. Papillary Ta nonmuscle invasive bladder cancer (NMIBC) specimens (n = 30) were selected graded by two 2004/2022 1973 categorized as LG 15), HG-G2 8), HG-G3 7), photographed at 10× 20×...
Sparing the periprostatic neurovascular bundles during robot-assisted radical prostatectomy (RARP) improves postoperative erectile function and early urinary continence recovery. The NeuroSAFE technique, a standardised frozen section analysis, enables accurate real-time detection of positive surgical margins nerve-sparing, increasing likelihood successful nerve preservation. However, impact technique on patient outcomes remains uncertain. We aimed to assess effect NeuroSAFE-guided RARP...
Abstract Objective To investigate the added value of systematic biopsies in men referred with suspected PCa undergoing visual registration targeted local anaesthetic transperineal prostate (LATPB) as their first biopsy for MRI‐P visible lesions (MRI Score≥3) a real‐world setting. Patients and methods The outcomes 2611 naïve MRI Score≥3 who underwent combined LATPB at 5 hospitals between 2021 2024 were studied. primary outcome was clinically significant (csPCa [Gleason≥ 3 + 4 = 7])) cancer...
Subungual keratotic tumours are rare. The clinical and histological distinctions between subungual keratoacanthomas (SUKAs) squamous cell carcinomas (SCCs) important, but often difficult. Adequate methods of differentiation the two required, both for purpose management assessment prognosis.To establish value immunohistochemical staining patterns proliferating cells to distinguish SUKAs SCCs.In total, 20 from patients were examined with techniques using bcl-2, Ki67 p53.Of patients, 4 had...
Vascular endothelial growth factor (VEGF) undergoes alternative splicing to produce both proangiogenic and antiangiogenic isoforms. Preferential of VEGF is determined by serine-arginine protein kinase 1 (SRPK1), which upregulated in a number cancers. In the present study, we aimed investigate SRPK1 expression prostate cancer (PCa) its association with progression. was assessed using immunohistochemistry PCa tissue extracted from radical prostatectomy specimens 110 patients. significantly...