A5049922672- Ethics in Clinical Research
- Patient-Provider Communication in Healthcare
- Prostate Cancer Diagnosis and Treatment
- Maternal and Perinatal Health Interventions
- Prostate Cancer Treatment and Research
- Health Systems, Economic Evaluations, Quality of Life
- Global Cancer Incidence and Screening
- Bladder and Urothelial Cancer Treatments
- Colorectal Cancer Screening and Detection
- Vascular Malformations Diagnosis and Treatment
- Pelvic floor disorders treatments
- Shoulder Injury and Treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Maternal and fetal healthcare
- Ethics in medical practice
- Mental Health and Patient Involvement
- Intracranial Aneurysms: Treatment and Complications
- Shoulder and Clavicle Injuries
- Data Analysis and Archiving
- Genetic factors in colorectal cancer
- Empathy and Medical Education
- Palliative Care and End-of-Life Issues
- Muscle and Compartmental Disorders
- Cervical and Thoracic Myelopathy
- Spectroscopy Techniques in Biomedical and Chemical Research
University of Bristol
2016-2025
Southmead Hospital
2020-2023
University of Aberdeen
2022
Manchester Metropolitan University
2022
Cardiff University
2022
University College London
2022
London School of Hygiene & Tropical Medicine
2022
Universidad de Londres
2022
University of Liverpool
2022
North Bristol NHS Trust
2018-2021
Pragmatic randomised controlled trials (RCTs) are considered essential to determine effective interventions for routine clinical practice, but many fail recruit participants efficiently, and some really important RCTs not undertaken because recruitment is thought be too difficult. The 'QuinteT Recruitment Intervention' (QRI) aims facilitate informed decision making by patients about RCT participation increase recruitment. This paper presents the development implementation of QRI. QRI...
BackgroundLong-term patient-reported outcomes are needed to inform treatment decisions for localized prostate cancer.MethodsPatient-reported of 1643 randomly assigned participants in the ProtecT (Prostate Testing Cancer and Treatment) trial were evaluated assess functional quality-of-life impacts prostatectomy, radiotherapy with neoadjuvant androgen deprivation, active monitoring. This article focuses on from 7 12 years using mixed effects linear logistic models.ResultsResponse rates...
Background Randomised controlled trials (RCTs) are essential for evidence-based medicine and increasingly rely on front-line clinicians to recruit eligible patients. Clinicians' difficulties with negotiating equipoise is assumed undermine recruitment, although these issues have not yet been empirically investigated in the context of observable events. We aimed investigate how conveyed during RCT recruitment appointments across six RCTs, a view (i) identifying practices that supported or...
To investigate the functional and quality of life (QoL) outcomes treatments for localised prostate cancer inform treatment decision-making.Men aged 50-69 years diagnosed with by prostate-specific antigen testing biopsies at nine UK centres in Prostate Testing Cancer Treatment (ProtecT) trial were randomised to, or chose one of, three treatments. Of 2565 participants, 1135 men received active monitoring (AM), 750 a radical prostatectomy (RP), 603 external-beam radiotherapy (EBRT) concurrent...
To explore how patients' treatment preferences were expressed and justified during recruitment to a randomized controlled trial (RCT) they influenced participation decisions.Qualitative analysis of audio recordings appointments with 93 participants aged 51-70 years in UK multicenter RCT localized prostate cancer treatments.Treatment at more complex dynamic than previously assumed. Most views about treatments early appointments, ranging on continuum from hesitant well-formed opinions. As...
Purpose To investigate the psychological impact of prostate biopsy, including relationships between physical biopsy-related symptoms and anxiety depression. Patients Methods A prospective cohort 1,147 men, nested within Prostate Testing for Cancer Treatment trial recommended to receive completed questionnaires assessing harms after biopsy in Biopsy Effects study. Psychological was measured using Hospital Anxiety Depression Scale, scores were compared according experiences at 7 35 days...
Rapid diagnostic pathways for cancer have been implemented, but evidence whether shorter intervals (time from primary care presentation to diagnosis) improves survival is lacking. Using the Clinical Practice Research Datalink, we identified patients diagnosed with female breast (8,639), colorectal (5,912), lung (5,737) and prostate (1,763) cancers between 1998 2009, aged >15 years. Presenting symptoms were classified as alert or non-alert, according National Institute Health Care Excellence...
It is common to undertake qualitative research alongside randomised controlled trials (RCTs) when evaluating complex interventions. Researchers tend analyse these datasets one by and then consider their findings separately within the discussion section of final report, rarely integrating quantitative data or findings, missing opportunities combine in order add rigour, enabling thorough more complete analysis, provide credibility results, generate further important insights about intervention...
Cervical traumatic spinal cord injury is a devastating condition. Current management (bony decompression) may be inadequate as after acute severe TSCI, the swollen become compressed against surrounding tough membrane, dura. DISCUS will test hypothesis that, acute, cervical injury, addition of dural decompression to bony improves muscle strength in limbs at 6 months, compared with alone.This prospective, phase III, multicenter, randomized controlled superiority trial. We aim recruit 222...
Background Prostate cancer is the most common among men in UK. Prostate-specific antigen testing followed by biopsy leads to overdetection, overtreatment as well undertreatment of disease. Evidence treatment effectiveness has lacked because paucity randomised controlled trials comparing conventional treatments. Objectives To evaluate treatments for localised prostate (active monitoring, radical prostatectomy and radiotherapy) aged 50–69 years. Design A prospective, multicentre...
Abstract Background More than a third of the 65,000 people living with kidney failure in UK attend dialysis unit 2–5 times week to have their blood cleaned for 3–5 h. In haemodialysis (HD), toxins are removed by diffusion, which can be enhanced using high-flux dialyser. This augmented convection, as occurs haemodiafiltration (HDF), and improved outcomes been reported who able achieve high volumes convection. study compares clinical- cost-effectiveness high-volume HDF compared HD treatment...
Pediatric therapists in school-based practice can incorporate exercise promotion through adaptive cycling for children with disabilities who experience high levels of sedentary behavior and low moderate to vigorous activity. The impacts an pilot program were investigated a community-based participatory study. During eight-week intervention, students had goal riding cycles three times week twenty minutes. Using pre-and post-test design, primary outcomes included individualized attainment...
ABSTRACT Introduction Fully informed consent is essential for ethical trial conduct, yet gaps in participant comprehension and recall can occur, particularly among underserved groups, example, ethnic minorities. This Patient Public Involvement Engagement (PPIE) project explored the engagement of minority communities recruitment discussions, their views about audio recording discussions with healthcare professionals. Methods PPIE engaged Bristol, collaborating community partners to facilitate...
The diagnosis of prostate cancer (PC) can provide a trigger for dietary change, and there is evidence that healthier diets may improve quality life clinical outcomes. However, men’s views about change in PC survivorship are largely unknown. This multi-centre qualitative interview study explored survivorship, to better understand motivations for, barriers to, achieving desired changes. role radical active surveillance treatments on the influence partners were examined. Focus groups also...
Many randomised controlled trials (RCTs) struggle to recruit, despite valiant efforts. The QRI (QuinteT Recruitment Intervention) uses innovative research methods optimise recruitment by revealing previously hidden barriers related the perceptions and experiences of recruiters patients, targeting remedial actions. It was designed be integrated with RCTs anticipating difficulties at outset. A new version intervention (QRI-Two) developed for already underway enrolment shortfalls.QRIs in 12...
Colorectal cancer survival in the UK is lower than other developed countries, but association of time interval between diagnosis and treatment on excess mortality remains unclear.Using data from registries England, we identified 46,511 patients with localised colorectal 1996-2009, who were 15 years older, underwent a major surgical resection within 62 days diagnosis. We used relative risk modeling to investigate (exposure) (outcome).Compared had 25-38 diagnosis, shorter those waiting longer...
<h2>Abstract</h2><h3>Objectives</h3> To explore how the concept of randomization is described by clinicians and understood patients in randomized controlled trials (RCTs) it contributes to patient understanding recruitment. <h3>Study Design Setting</h3> Qualitative analysis 73 audio recordings recruitment consultations from five, multicenter, UK-based RCTs with identified or anticipated difficulties. <h3>Results</h3> One 10 appointments did not include any mention randomization. Most...
Abstract Introduction The COVID-19 pandemic impacted the operationalisation of non-COVID-19 clinical trials globally, particularly site and participant recruitment trial success/stoppage. Trials which anticipate challenges may embed methods such as QuinteT Recruitment Intervention (QRI) to help identify understand sources challenges. Such interventions can shed light on pandemic-related This paper reports our experience impact conducting with an embedded QRI, highlighting how QRI aided in...
Objectives To develop a nurse-led, urologist-supported model of care for men managed by active surveillance or monitoring (AS/AM) localised prostate cancer and provide formative evaluation its acceptability to patients, clinicians nurses. Nurse-led care, comprising an explicit nurse-led protocol with support from urologists, was developed as part the AM arm Prostate testing Treatment (ProtecT) trial. Design Interviews questionnaire surveys clinicians, nurses patients assessed acceptability....
It was anticipated that recruitment to the Cavernous malformations: A Randomised Effectiveness (CARE) pilot randomised trial would be challenging. The compared medical management and surgery (neurosurgical resection or stereotactic radiosurgery) with alone, for people symptomatic cerebral cavernous malformation (ISRCTN41647111). Previous trials comparing surgical intracranial vascular malformations failed recruit target. QuinteT Recruitment Intervention integrated during accrual, September...
Survival from breast cancer in the United Kingdom is lower than other developed countries. It unclear to what extent waiting times for curative surgery affect survival. Using national databases England (cancer registries, Hospital Episode Statistics and Office of National Statistics), we identified 53 689 women with localised cancer, aged ⩾15 years, diagnosed between 1996 2009, who had surgical resection intent within 62 days diagnosis. We used relative survival excess risk modelling...
A diagnosis of prostate cancer leads to emotional distress and anxiety, prompting calls for rapid diagnostic pathways. Nevertheless, it remains unclear what impact time between surgery has upon survival. Using national databases England (cancer registries, Hospital Episode Statistics Office National Statistics), we identified 17,043 men with cancer, aged 15 years older, diagnosed in 1996–2009, who had surgical resection curative intent within 6 months diagnosis. We used relative survival...
The histological diagnosis of prostate cancer requires a needle biopsy. Little is known about the relationship between information provided to prepare men for transrectal ultrasound guided biopsy (TRUS-Bx) and how experience objectives were a) understand men's experiences as compared their expectations; b) propose current evidence-based undergoing TRUS-Bx.