A5023584107- Prostate Cancer Diagnosis and Treatment
- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Prostate Cancer Treatment and Research
- Respiratory and Cough-Related Research
- Bladder and Urothelial Cancer Treatments
- Pediatric health and respiratory diseases
- Antibiotic Use and Resistance
- Neonatal and fetal brain pathology
- Pneumonia and Respiratory Infections
- Innovations in Medical Education
- Ethics in Clinical Research
- Asthma and respiratory diseases
- Patient-Provider Communication in Healthcare
- Cerebrospinal fluid and hydrocephalus
- 3D Printing in Biomedical Research
- Microfluidic and Bio-sensing Technologies
- Global Cancer Incidence and Screening
- Healthcare Systems and Technology
- Health Systems, Economic Evaluations, Quality of Life
- Cutaneous lymphoproliferative disorders research
- Inflammatory Bowel Disease
- Patient Satisfaction in Healthcare
- Diabetes and associated disorders
- Interprofessional Education and Collaboration
University of Bristol
2016-2025
Pennsylvania State University
2025
The Ohio State University
2010-2025
Harvard University
2015-2023
At Bristol
2020-2023
Institute of Population and Public Health
2023
A.T. Still University
2023
South Pointe Hospital
2023
Cleveland Clinic
2023
Massachusetts General Hospital
2021
Between 1999 and 2009 in the United Kingdom, 82,429 men between 50 69 years of age received a prostate-specific antigen (PSA) test. Localized prostate cancer was diagnosed 2664 men. Of these men, 1643 were enrolled trial to evaluate effectiveness treatments, with 545 randomly assigned receive active monitoring, 553 undergo prostatectomy, radiotherapy.
Importance Prostate cancer screening remains controversial because potential mortality or quality-of-life benefits may be outweighed by harms from overdetection and overtreatment. Objective To evaluate the effect of a single prostate-specific antigen (PSA) intervention standardized diagnostic pathway on prostate cancer–specific mortality. Design, Setting, Participants The Cluster Randomized Trial PSA Testing for Cancer (CAP) included 419 582 men aged 50 to 69 years was conducted at 573...
BackgroundLong-term patient-reported outcomes are needed to inform treatment decisions for localized prostate cancer.MethodsPatient-reported of 1643 randomly assigned participants in the ProtecT (Prostate Testing Cancer and Treatment) trial were evaluated assess functional quality-of-life impacts prostatectomy, radiotherapy with neoadjuvant androgen deprivation, active monitoring. This article focuses on from 7 12 years using mixed effects linear logistic models.ResultsResponse rates...
Importance The Cluster Randomized Trial of PSA Testing for Prostate Cancer (CAP) reported no effect prostate-specific antigen (PSA) screening on prostate cancer mortality at a median 10-year follow-up (primary outcome), but the long-term effects remain unclear. Objective To evaluate single invitation cancer–specific 15-year compared with screening. Design, Setting, and Participants This secondary analysis CAP randomized clinical trial included men aged 50 to 69 years identified 573 primary...
The ProtecT trial reported intention-to-treat analysis of men with localised prostate cancer (PCa) randomly allocated to active monitoring (AM), radical prostatectomy, and external beam radiotherapy. To determine report outcomes according treatment received in randomised choice cohorts. This study focuses on secondary care. Men clinically at one nine UK centres were invited participate the comparing AM, Two cohorts included 1643 who agreed be randomised; 997 declined randomisation chose...
To investigate the functional and quality of life (QoL) outcomes treatments for localised prostate cancer inform treatment decision-making.Men aged 50-69 years diagnosed with by prostate-specific antigen testing biopsies at nine UK centres in Prostate Testing Cancer Treatment (ProtecT) trial were randomised to, or chose one of, three treatments. Of 2565 participants, 1135 men received active monitoring (AM), 750 a radical prostatectomy (RP), 603 external-beam radiotherapy (EBRT) concurrent...
Objective To test the hypothesis that baseline clinico‐pathological features of men with localized prostate cancer (PCa) included in ProtecT (Prostate Testing for Cancer and Treatment) trial who progressed ( n = 198) at a 10‐year median follow‐up were different from those stable disease 1409). Patients Methods We stratified study participants according to risk progression using clinical stage, pathological grade PSA level, Cox proportional hazard models. Results The findings showed 34% 505)...
Background Progressive ventricular dilatation after intraventricular haemorrhage (IVH) in preterm infants has a very high risk of severe disability and death. Drainage, irrigation fibrinolytic therapy (DRIFT), randomised controlled trial (RCT), reduced cognitive impairment at 2 years. Objective To assess if the advantage DRIFT seen years persisted until school age. Participants The RCT conducted four centres recruited 77 with IVH progressive enlargement over specified measurements. Follow-up...
Nicotine and other nicotinic agents are thought to regulate mood in human subjects have antidepressant-like properties animal models. Recent studies demonstrated that blockade of acetylcholine receptors (nAChRs) including those containing the β2 subunit (β2<sup>*</sup>), results effects. Previous shown cytisine, a partial agonist at α4/β2<sup>*</sup> nAChRs, full α3/β4<sup>*</sup> α7 has several rodent models antidepressant efficacy; however, it is not clear whether more selective agonists...
Objectives To present the baseline patient‐reported outcome measures ( PROM s) in Prostate Testing for Cancer and Treatment (ProtecT) randomized trial comparing active monitoring, radical prostatectomy external‐beam conformal radiotherapy localized prostate cancer to compare results with other populations. Materials Methods A total of 1643 men, aged 50–69 years diagnosed clinically disease identified by prostate‐specific antigen PSA ) testing, nine UK cities period 1999–2009 were included....
Lower urinary tract symptoms (LUTS) comprise storage symptoms, voiding and post-voiding symptoms. Prevalence severity of LUTS increase with age the progressive in aged population group has emphasised importance to our society appropriate effective management male LUTS. Identification causal mechanisms is needed optimise treatment uroflowmetry simplest non-invasive test function. Invasive urodynamics can evaluate function function; however, there currently insufficient evidence support...
Background Prostate cancer is the most common among men in UK. Prostate-specific antigen testing followed by biopsy leads to overdetection, overtreatment as well undertreatment of disease. Evidence treatment effectiveness has lacked because paucity randomised controlled trials comparing conventional treatments. Objectives To evaluate treatments for localised prostate (active monitoring, radical prostatectomy and radiotherapy) aged 50–69 years. Design A prospective, multicentre...
Abstract Background Antibiotics are prescribed for over 50% of RTIs in primary care, despite good evidence most patients do not benefit. Rapid multiplex microbiological point-of-care-tests (POCTRM) determine the presence/ absence respiratory pathogens 15 min. Whether POCTRM reduce antibiotic prescribing without worsening patient outcomes is known. Objectives To investigate whether can (i) same-day children and adults presenting to care with RTIs; (ii) change symptom severity on Days 2 4....
Lower urinary tract symptoms (LUTS) are a key indication for surgery in older men. The Urodynamics Prostate Surgery Trial; Randomised Evaluation of Assessment Methods (UPSTREAM) study evaluated the diagnostic pathway men considering to treat LUTS and reported outcomes at 18 mo. This long-term follow-up reports rates prostate 5 yr. UPSTREAM participants who had consented received postal questionnaires yr after randomisation (October 2019-December 2021). primary outcome was patient-reported...
The DNA genome is constantly exposed to agents, such as ultraviolet radiation (UVR), that can alter or eliminate its coding properties through covalent modifications of the template bases. Many these damaging (i.e., lesions) persist into S-phase cell cycle where they may stall canonical replication machinery. In humans, stalling events are circumvented by one at least three interconnected damage tolerance (DDT) pathways; translesion synthesis (TLS), Template Switching (TS), and...
The selection and collection of single cells from within a heterogeneous population is required to produce genetically engineered cell lines, develop new stem for single-cell studies. We describe platform the positive live mammalian while remain adherent their growth surface. Cells were grown on arrays microfabricated, releasable elements composed SU-8 polymer termed "cell pallets". presence air between restricted top surfaces pallets. Single pallets situated large released demand using...
<h3>Importance</h3> Acute lower respiratory tract infection is common and often treated inappropriately in primary care with antibiotics. Corticosteroids are increasingly used but without sufficient evidence. <h3>Objective</h3> To assess the effects of oral corticosteroids for acute adults asthma. <h3>Design, Setting, Participants</h3> Multicenter, placebo-controlled, randomized trial (July 2013 to final follow-up October 2014) conducted 54 family practices England among 401 cough at least 1...
Acute otitis media (AOM) is a common reason for primary care consultations and antibiotic prescribing in children. Options improved pain control may influence consumption. The Children's Ear Pain Study (CEDAR) investigated whether or not providing anaesthetic-analgesic ear drops reduced consumption children with AOM. Secondary objectives included cost-effectiveness. A multicentre, randomised, parallel-group (two-group initially, then three-group) trial. Primary practices England Wales. 1- to...
Background The drainage, irrigation and fibrinolytic therapy (DRIFT) trial, conducted in 2003–6, showed a reduced rate of death or severe disability at 2 years the DRIFT compared with standard treatment group, among preterm infants intraventricular haemorrhage (IVH) post-haemorrhagic ventricular dilatation. Objectives To compare cognitive function, visual sensorimotor ability, emotional well-being, use specialist health/rehabilitative educational services, neuroimaging, economic costs...
BackgroundAssessment of male lower urinary tract symptoms (LUTS) needs to identify predictors symptom outcomes when interventional treatment is planned.ObjectiveTo develop a novel prediction model for prostate surgery and validate it using separate patient cohort derive thresholds key clinical parameters.Design, setting, participantsFrom the UPSTREAM trial 820 men seeking LUTS, analysis bladder diary (BD), International Prostate Symptom Score (IPSS), IPSS-quality life, uroflowmetry data was...
Objectives Cross-sectional studies suggest that around 6% of men undergo prostate-specific antigen (PSA) testing each year in UK general practice (GP). This longitudinal study aims to determine the cumulative pattern over a 10-year period and whether this can be considered equivalent screening for prostate cancer (PCa). Setting, participants outcome measures Patient-level data on PSA tests, biopsies PCa diagnoses were obtained from Clinical Practice Research Datalink (CPRD) years 2002 2011....