A5002179353- Pneumonia and Respiratory Infections
- Respiratory and Cough-Related Research
- Asthma and respiratory diseases
- Respiratory viral infections research
- Antibiotic Use and Resistance
- Influenza Virus Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Bacterial Infections and Vaccines
- Health Policy Implementation Science
- Pediatric health and respiratory diseases
- Thermal Regulation in Medicine
- Bacterial Identification and Susceptibility Testing
- Delphi Technique in Research
- Climate Change and Health Impacts
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Thermoregulation and physiological responses
- Patient Satisfaction in Healthcare
- Tracheal and airway disorders
- Health Systems, Economic Evaluations, Quality of Life
- Nursing Diagnosis and Documentation
- Inhalation and Respiratory Drug Delivery
- Family and Patient Care in Intensive Care Units
- Mental Health and Patient Involvement
- Urinary Tract Infections Management
University of Oxford
2014-2025
University of Southampton
2023-2025
National Institute for Health Research
2020
Primary Health Care
2017-2019
BackgroundAntibiotic resistance is a global public health threat. Antibiotics are very commonly prescribed for children presenting with uncomplicated lower respiratory tract infections (LRTIs), but there little evidence from randomised controlled trials of the effectiveness antibiotics, both overall or among key clinical subgroups. In ARTIC PC, we assessed whether amoxicillin reduces duration moderately bad symptoms in (non-pneumonic) LRTI primary care, and subgroups.MethodsARTIC PC was...
There remains public misconception about antibiotic use and resistance. Preschool children are at particular risk of receiving unnecessary antibiotics because they commonly present in primary care many childhood infections self-limiting. The aim our study was to explore parents' perceptions understanding resistance the context their young child with an acute respiratory tract infection (RTI) strategies parents would find acceptable minimize for families. Semi-structured interviews were...
Aim We aimed to identify enablers and barriers of using primary care routine data for healthcare research, formulate recommendations improving efficiency in knowledge discovery. Background Data recorded routinely can be used estimating the impact interventions provided within all people who are clinically eligible. Despite official promotion ‘efficient trial designs’, anecdotally researchers Asthma UK Centre Applied Research (AUKCAR) have encountered multiple accessing data. Methods Using...
Background Clinical decision support systems (CDSSs) can promote adherence to clinical guidelines and improve patient outcomes. Exploring implementation determinants during the development of CDSSs enables intervention optimisation acceptability, perceived appropriateness fidelity subsequent implementation. This study sought explore how clinicians perceive use a CDSS which makes recommendations for asthma management based on factors including Fractional exhaled Nitric Oxide testing, be...
Abstract Fractional exhaled nitric oxide (FeNO) testing is used in primary care some areas of the UK to aid asthma diagnosis but less frequently for managing asthma. A randomised controlled trial (RCT) investigating whether an intervention, including FeNO and a clinical algorithm, improves outcomes patients with This study was conducted explore potential implementation intervention. The aim views those vested interest implementing intervention into reviews. In-depth, semi-structured...
BackgroundPostinfectious cough is common in primary care, but has no proven effective treatments. Cysteinyl leukotrienes are involved the pathogenesis of postinfectious and whooping (pertussis). We investigated effectiveness montelukast, a cysteinyl leukotriene receptor antagonist, treatment cough.MethodsIn this randomised, placebo-controlled trial, non-smoking adults aged 16–49 years with 2–8 weeks' duration were recruited from 25 general practices England. Patients tested for pertussis...
<h3>Importance</h3> Acute lower respiratory tract infection is common and often treated inappropriately in primary care with antibiotics. Corticosteroids are increasingly used but without sufficient evidence. <h3>Objective</h3> To assess the effects of oral corticosteroids for acute adults asthma. <h3>Design, Setting, Participants</h3> Multicenter, placebo-controlled, randomized trial (July 2013 to final follow-up October 2014) conducted 54 family practices England among 401 cough at least 1...
Objective To estimate the prevalence and clinical severity of whooping cough (pertussis) in school age children presenting with persistent primary care since introduction implementation preschool pertussis booster vaccination. Design Prospective cohort study (November 2010 to December 2012). Setting General practices Thames Valley, UK. Participants 279 aged 5 15 years who presented a two eight weeks’ duration. Exclusion criteria were likely be caused by serious underlying medical condition,...
Objectives National Institute for Health and Care Excellence guidelines recommend immediate antibiotic treatment of respiratory tract infections in ‘at-risk’ individuals with comorbidities. Observational evidence suggests that influenza particularly predisposes children to bacterial complications. This study investigates general practitioners’ (GPs’) accounts factors influencing their decision-making about prescribing the management at-risk influenza-like illness (ILI). Design Qualitative...
Temperature is an important vital sign for assessing acutely unwell children, and measured frequently in primary care. However, measuring temperature accurately can be challenging. Oral rectal thermometers are invasive poorly tolerated, while axillary require parents or healthcare professionals to undress the child hold thermometer axilla 30 seconds longer. Infrared tympanic easier use, but inaccurate due ear wax insufficient straightening of canal. Non-contact infrared (NCITs) designed...
Background: Persistent cough following an acute respiratory tract infection is common in children, but clinicians may find it difficult to give accurate prognostic information on likely duration of without a microbiologic diagnosis. This study estimates the prevalence Mycoplasma pneumoniae (Mp) and assesses value detecting Mp viruses children with persistent cough. Methods: We retrospectively analyzed blood samples, nasopharyngeal aspirates (NPAs), data from 179 lasting 14 days or longer. Of...
Background Guidelines recommend measuring temperature in children presenting with fever using electronic axillary or tympanic thermometers. Non-contact thermometry offers advantages, yet has not been tested against recommended methods primary care. Aim To compare two different non-contact infrared thermometers (NCITs) to and aged ≤5 years visiting their GP an acute illness. Design setting Method comparison study nested qualitative component. Temperature measurements were taken (Welch Allyn...