A5042614530- Clinical Laboratory Practices and Quality Control
- Healthcare cost, quality, practices
- Meta-analysis and systematic reviews
- Diabetes Management and Research
- Health Systems, Economic Evaluations, Quality of Life
- Dialysis and Renal Disease Management
- Acute Myocardial Infarction Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Clinical practice guidelines implementation
- Chronic Kidney Disease and Diabetes
- Heart Failure Treatment and Management
- Health Sciences Research and Education
- Monoclonal and Polyclonal Antibodies Research
- Metabolomics and Mass Spectrometry Studies
- Primary Care and Health Outcomes
- Advanced Biosensing Techniques and Applications
- Biochemical and Molecular Research
- Healthcare Policy and Management
- Alkaline Phosphatase Research Studies
- Polyamine Metabolism and Applications
- Microfluidic and Bio-sensing Technologies
- Diabetes and associated disorders
- Venous Thromboembolism Diagnosis and Management
- Biosensors and Analytical Detection
- Health and Medical Research Impacts
Newcastle University
2024-2025
University of Oxford
2014-2024
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2024
National Heart Lung and Blood Institute
2024
Observational & Pragmatic Research Institute
2023
Queen Mary University of London
1990-2020
Nuffield Health
2016-2017
NIHR Leeds In Vitro Diagnostics Co-operative
2017
National Institute for Health Research
2017
Co-operative College
2016
Glomerular filtration rate (GFR) is routinely assessed by measuring the concentrations of endogenous serum markers such as blood urea nitrogen and creatinine (SCr). Although widely used, these are not ideal do perform optimally in certain clinical settings. The purpose this review to critically potential utility cystatin C (CysC), especially patient populations which CysC may have an advantage over used GFR.In a narrative approach, we extensively publications, primarily from last 5 years,...
Objective Despite the growing number of point-of-care (POC) tests available, little research has assessed primary care clinician need for such tests. We therefore aimed to determine which POC they actually use or would like (if not currently available in their practice). Design Cross-sectional survey. Setting Primary Australia, Belgium (Flanders region only), Netherlands, UK and USA. Participants doctors (general practitioners, family physicians). Main measures asked respondents (1) identify...
Abstract Serum cystatin C has been suggested as a new marker of glomerular filtration rate (GFR). We describe fully automated and rapid particle-enhanced nephelometric immunoassay (PENIA) for measuring serum on the Behring nephelometer systems (BNA, BN II). Each sample is analyzed in 6 min with many 75 samples per batch. The assay covers range 0.23–7.25 mg/L, up to seven times upper limit normal. intra- interassay imprecision are <3.3% <4.5%, respectively. There absolute...
Serum cardiac troponin concentrations are commonly increased in end-stage renal disease (ESRD) the absence of an acute coronary syndrome (ACS). The data on I (cTnI) more variable than those for T (cTnT). There is little information patients with chronic kidney (CKD) who have not commenced dialysis.We studied 222 patients: 56 had stage 3 (moderate CKD); 70 4 (severe and 96 5 (kidney failure). Patients underwent echocardiography were followed prospectively a median 19 months; all-cause...
The NIH is committed to improving healthcare quality in the US and has set up initiatives address problems such as fragmented nature of provision. A hypothesis been developed that testing closer point at which care delivered may reduce fragmentation improve outcomes.The National Institute Biomedical Imaging Bioengineering (NIBIB), NIH's Heart, Lung, Blood Institute, Science Foundation sponsored a workshop, "Improving Health Care Accessibility through Point-of-Care Technologies," April 2006....
There is an implicit acceptance that evidence-based culture underpins the practice of laboratory medicine, in part because it perceived as scientific foundation medicine. However, several reviews specific test procedures or technologies have shown evidence base limited and many cases flawed. One key deficiencies literature on diagnostic tests often absence explicit statement clinical need, i.e., operational question use seeking to answer. Several also demonstrated experimental methodology...
Current literature suggests that myocarditis is a common event during influenza infection, occurring with prevalence rate of up to 10%, but these studies have relied on relatively nonspecific techniques varying sensitivities for the detection myocyte injury. Using measurement cardiac troponins I and T, this study sought determine in large unselected cohort patients serologically confirmed acute infection.A total 152 subjects were recruited from 60 primary care university health centers....