A5076640899- Acute Myocardial Infarction Research
- Dialysis and Renal Disease Management
- Heart Failure Treatment and Management
- Renal and Vascular Pathologies
- Cardiac electrophysiology and arrhythmias
- Chronic Kidney Disease and Diabetes
- Cardiovascular Effects of Exercise
East Kent Hospitals University NHS Foundation Trust
2005-2024
This study directly demonstrates that cardiac troponin I (cTnI) is a sensitive, specific, and persistent biomarker in laboratory animals. Histopathological pathophysiological changes dogs, rats mice correlated with increased serum cTnI various inotropic agents, cardiotoxic drugs arrhythmias, tachycardia, effusion dyspnoea, ageing. A comparison of six immunoassays for T (cTnT) to detect monitor injury rodent model indicated enzyme-linked immunosorbent (Life Diagnostics Inc TriChem Resources...
Serum cardiac troponin concentrations are commonly increased in end-stage renal disease (ESRD) the absence of an acute coronary syndrome (ACS). The data on I (cTnI) more variable than those for T (cTnT). There is little information patients with chronic kidney (CKD) who have not commenced dialysis.We studied 222 patients: 56 had stage 3 (moderate CKD); 70 4 (severe and 96 5 (kidney failure). Patients underwent echocardiography were followed prospectively a median 19 months; all-cause...
Estimation of glomerular filtration rate using equations based on creatinine is widely used to manage chronic kidney disease. In the UK, Chronic Kidney Disease Epidemiology Collaboration equation recommended. Other published cystatin C, an alternative marker function, have not gained widespread clinical acceptance. Given higher cost its utility should be validated before introduction into NHS.