A5055489849- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Analytical Methods in Pharmaceuticals
- Crystallization and Solubility Studies
- Advancements in Transdermal Drug Delivery
- Crystallography and molecular interactions
- Nanoparticle-Based Drug Delivery
- Pharmaceutical studies and practices
- 3D Printing in Biomedical Research
- Radiopharmaceutical Chemistry and Applications
- Analytical Chemistry and Chromatography
- Hydrogels: synthesis, properties, applications
- Antibiotics Pharmacokinetics and Efficacy
- Computational Drug Discovery Methods
- Innovative Microfluidic and Catalytic Techniques Innovation
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Synthesis and Characterization of Heterocyclic Compounds
- Dialysis and Renal Disease Management
- Advanced Chemical Sensor Technologies
- Pharmacological Effects of Natural Compounds
- Synthesis of Tetrazole Derivatives
- Acute Myocardial Infarction Research
- X-ray Diffraction in Crystallography
- Pharmacogenetics and Drug Metabolism
University of Karachi
2020-2025
International Center for Chemical and Biological Sciences
2020-2025
University of the Punjab
2015-2024
Soonchunhyang University
2024
Quaid-i-Azam University
2016-2023
Riphah International University
2017-2023
University of Faisalabad
2023
Combined Military Hospital
2023
University of Agriculture Faisalabad
2023
Nishtar Medical College and Hospital
2023
Serum cardiac troponin concentrations are commonly increased in end-stage renal disease (ESRD) the absence of an acute coronary syndrome (ACS). The data on I (cTnI) more variable than those for T (cTnT). There is little information patients with chronic kidney (CKD) who have not commenced dialysis.We studied 222 patients: 56 had stage 3 (moderate CKD); 70 4 (severe and 96 5 (kidney failure). Patients underwent echocardiography were followed prospectively a median 19 months; all-cause...
Purpose: This study was aimed to develop doxorubicin-loaded quaternary ammonium palmitoyl glycol chitosan (DOX–GCPQ) nanoformulation that could enable DOX delivery and noninvasive monitoring of drug accumulation biodistribution at tumor site utilizing self-florescent property doxorubicin. Materials methods: DOX–GCPQ amphiphilic polymeric nanoformulations were prepared optimized using artificial neural network (ANN) characterized for surface morphology by atomic force microscopy, particle...
Overweight and obesity is a global epidemic. Forecasting future trajectories of the epidemic crucial for providing an evidence base policy change. In this study, we examine historical trends global, regional, national prevalence adult overweight from 1990 to 2021 forecast 2050. Leveraging established methodology Global Burden Diseases, Injuries, Risk Factors Study, estimated among individuals aged 25 years older by age sex 204 countries territories Retrospective current were derived based on...
Background The aim of this study was to investigate therapeutic efficacy and normal tissue toxicity single dosage fractionated targeted alpha therapy (TAT) in mice with HER2-expressing breast ovarian cancer xenografts using the low dose rate radioimmunoconjugate 227Th-DOTA-p-benzyl-trastuzumab. Methodology/Principal Findings Nude carrying HER2-overexpressing subcutaneous SKOV-3 or SKBR-3 were treated 1000 kBq/kg 227Th-trastuzumab as injection four injections 250 intervals 4–5 days, 2 weeks,...
The aim of the present study was to explore biodistribution, normal tissue toxicity, and therapeutic efficacy internalizing low-dose rate alpha-particle-emitting radioimmunoconjugate 227Th-trastuzumab in mice with HER2-expressing breast cancer xenografts. Biodistribution 227Th-rituximab nude bearing SKBR-3 xenografts were determined at different time points after injection. Tumor growth measured administration 227Th-trastuzumab, 227Th-rituximab, cold trastuzumab, saline. toxicity evaluated...
Purpose: To develop and evaluate nanosponge (NS) based sustained release formulations of naproxen (NAP) ibuprofen (IBU).Method: Six each candidate drug were prepared by emulsion solvent diffusion method, using varying ratios polymers, i.e., ethyl cellulose polyvinyl alcohol. The evaluated for various parameters including production yield, particle size, polydispersity index, actual content entrapment efficiency. Morphological, structural thermo-analytical evaluations performed techniques. In...
The aim of this study was to fabricate Bacillus Calmette–Guérin (BCG)-loaded microneedle patches using micromould casting technique and compare their efficacy with the injectable counterparts. were formulated sodium alginate (10% w/v) trehalose (20% polymer). characterised optical microscopy, scanning electron microscopy folding endurance. Serum IgG, TLC, granulocyte count, lymphocyte count CRP assessed results compared that intradermal injections alongside controls. showed polymeric had a...
Abstract Water is a primary element for human life on Earth. Fresh water, which includes rivers, lakes, streams, and ponds, contributes less than one thousandth of percent the total water Earth, but it critical environment life. Change in land use cover (LULC) foremost concern global change. Rapid changes LULC lead to degradation ecosystems have adverse effects environment. There an urgent need monitor evaluate these order inform decision makers how support sustainable development. This...
Abstract Herein, we used sol-gel auto combustion technique for fabrication of the series nickel substituted magnesium-zinc spinel ferrite (Mg 0.3 Ni x Zn 0.7−x Fe 2 O 4 ) nanoparticles by varying concentrations as 0.00 ≤ 0.20. X-ray diffraction (XRD) investigation evidenced that synthesized nanomaterials are nature with secondary phase. Moreover, crystallite size was observed to be in range from 13 17 nm estimated Scherrer’s formula. It has been found structural parameters (e.g., bulk...
Reiner–Rivlin nanofluid flow due to rotating disk has significance in manufacturing of computer disks, pumping liquid metals, spin coating, centrifugal machinery, turbo-machinery, crystal growth and rotational viscometer. In light such real relevant industrial applications, this study deals with the numerical investigation unsteady rotationally symmetric over a stretchable disk. The purpose is explore heat transfer characteristics subject radial stretched surface implementable several...
Silver ions (Ag+) are crucial in various fields, but pose environmental and health risks at high concentrations. This study presents a straightforward approach for the ultra-trace detection of Ag+, utilizing composite cytosine-rich oligonucleotide (CRO) an electrochemically reduced graphene oxide (ERGO). Initially, ERGO was synthesized on glassy carbon electrode (GCE) through reduction (GO) via cyclic voltammetry. A methylene blue-tagged CRO (MB-CRO) then anchored to surface π–π...
The aim of the current study was to investigate therapeutic effect 227Th-radioimmunotherapy on intraperitoneally growing human bioluminescent HER2 positive ovarian cancer cells.In vitro toxicity 227Th-trastuzumab in SKOV3-luc-D3 cells assessed a growth assay. biodistribution administrated athymic nude mice without tumor determined. For vivo therapy, seventy female were inoculated with 17 days prior injection single doses 1000 kBq/kg, 600 kBq/kg or 400 three injections separated by 4 weeks....
Background Osteosarcoma is a rare form of cancer but with substantial need for new active drugs. There particular targeted therapies to combat metastatic disease. One possible approach use an antibody drug conjugate or radionuclide target the osteosarcoma metastases and circulating tumor cells. Herein we have evaluated radiolabeled monoclonal targeting CD146 both in vitro vivo. Methods Results A murine anti-CD146 IgG1 isotype antibody, named OI-3, was developed along recombinant chimeric...
Purpose: To develop polymeric nanosponge based hydrogel system of fluconazole (FZ) for improved delivery topical application.Method: Six different preparations were formulated by oil-in-water (o/w) emulsion solvent diffusion method using various drug to polymer (ethylcellulose, EC) ratios. Polyvinyl alcohol (PVA) and dichloromethane used prepare the aqueous dispersed phases, respectively. The nanosponges (NS) studied entrapment efficiency, particle size, structural properties, size...
Agarose (AG) is a naturally occurring biocompatible marine seaweed extract that converted to hydrocolloid gel in hot water with notable strength. Currently, its mucoadhesion properties have not been fully explored. Therefore, the main aim of this study was evaluate mucoadhesive potential AG binary dispersions combination Carbopol 934P (CP) as preparations. The gels fabricated via homogenization were evaluated for ex vivo mucoadhesion, swelling index (SI), dissolution and stability studies....