A5009275103- Regulation of Appetite and Obesity
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- HIV/AIDS drug development and treatment
- Neonatal Health and Biochemistry
- Machine Learning in Bioinformatics
- Bioinformatics and Genomic Networks
- Adipose Tissue and Metabolism
- Metabolism and Genetic Disorders
- Problem and Project Based Learning
- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Parathyroid Disorders and Treatments
- HIV Research and Treatment
- Innovations in Medical Education
- SARS-CoV-2 and COVID-19 Research
- Pharmaceutical studies and practices
- Sirtuins and Resveratrol in Medicine
- Advanced Breast Cancer Therapies
- Genetics, Bioinformatics, and Biomedical Research
- Biomedical and Engineering Education
Apollo Institute of Medical Sciences & Research
2024-2025
K S Hegde Medical Academy
2017-2024
Sri Venkateswara University
2024
Weatherford College
2022
Kidwai Memorial Institute of Oncology
2001-2020
Nitte University
2017-2019
Institute of Medical Sciences
2015-2017
Indira Gandhi Medical College and Research Institute
2014
Tata Steel (India)
2009
Kasturba Medical College, Manipal
2007-2009
Overweight and obesity is a global epidemic. Forecasting future trajectories of the epidemic crucial for providing an evidence base policy change. In this study, we examine historical trends global, regional, national prevalence adult overweight from 1990 to 2021 forecast 2050. Leveraging established methodology Global Burden Diseases, Injuries, Risk Factors Study, estimated among individuals aged 25 years older by age sex 204 countries territories Retrospective current were derived based on...
Despite the well documented consequences of obesity during childhood and adolescence future risks excess body mass on non-communicable diseases in adulthood, coordinated global action early life is still insufficient. Inconsistent measurement reporting are a barrier to specific targets, resource allocation, interventions. In this Article we report current estimates overweight across adolescence, progress over time, forecasts inform actions. Using established methodology from Global Burden...
Epidemiologic studies demonstrate a relation between preeclampsia and an increased risk of future maternal coronary heart disease. The pathophysiology the underlying mechanism is unknown. Disorders lipoprotein metabolism may contribute to endothelial dysfunction. Oxidative stress decreased antioxidant defense enhances free radical-mediated membrane lipid peroxidation possibly vascular damage. aim this study was elucidate possible lipidemic status, albumin with total activity (AOA) that...
<ns4:p>Introduction Leptin, along with its receptor, are linked mechanisms affecting a diverse array of pregnancy-specific pathologies that include gestational diabetes and intrauterine growth restriction. The goal the study was to examine if there link between leptin (LEP)/leptin receptor (LEPR) gene polymorphism insulin resistance in pregnant women, determine extent which could cause resistance. Methods 208 women participated this cross-sectional 74 were resistant cases 134 sensitive...
Background: Gallbladder cancer (GBC) is a highly aggressive malignancy with limited therapeutic options and poor prognosis. This study integrates bioinformatics machine learning (ML) approaches to analyze the transcriptional changes in GBC identify potential targets. Methods: The NCBI GEO database was used gather published microarray data gene expression patterns of cells stimulated chenodeoxycholic acid (CDCA), analyzed using RNA-seq differentially expressed genes (DEGs). R software process...
<title>Abstract</title> <bold>Background:</bold> Coronary heart disease (CHD) is a leading cause of mortality worldwide, with complex interplay genetic and environmental factors influencing its development. Genome-wide association studies (GWAS) have identified multiple loci associated CHD, providing crucial insights into pathophysiology. However, the full spectrum contributors their biological mechanisms remains to be elucidated. <bold>Methods:</bold> This study integrates GWAS data...
Type 2 diabetes mellitus (T2DM) is a chronic disease that characterized by impaired glucose metabolism and insulin resistance. The objectives of the study were to evaluate pattern leptin receptor gene polymorphism Gln223Arg in T2DM identify its association with serum levels as well resistance diabetes.In this cross-sectional study, genotyping was done for alleles PCR-restriction fragment length 39 patients type diabetes. Serum assayed using enzyme linked sorbent assay cases 45 nondiabetic...
Liver disorder is known to be a risk factor for Diabetes Mellitus (DM) and diabetic patients are at of developing liver disorders. Association renal disease less explored in the field research; hence, we conducted retrospective study on this.
Objective: Benign massive ovarian oedema is a rare clinical entity arising from the ovaries, and it poses significant challenge as can be easily mistaken for neoplasm.Due to lack of pathognomonic features or characteristic hallmarks on non-invasive diagnostic modalities dependence final histopathology, efforts surgeon have been deviated performing fertilitysparing surgery young women.The standardised guidelines due rarity this condition calls review literature enable clinician formulate...
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to defects in insulin secretion, action, or both. Chronic induces reactive oxygen species and increases oxidative stress. Human serum paraoxonase-1 (PON-1) an enzyme synthesized the liver, it antioxidant with beneficial role fighting The objective of study was compare PON-1 activity type 2 diabetes (T2DM) nondiabetics, as well find association between different resistance (IR) models diabetics.The cross-sectional...
<ns3:p><ns3:bold>Introduction:</ns3:bold> Leptin is an adipokine hormone that regulates insulin sensitivity and lipid profile, which may contribute to complications like gestational diabetes.The goal of the study was examine if there a link between leptin (LEP)/leptin receptor (LEPR) gene polymorphism resistance in pregnant women, determine extent could cause resistance..</ns3:p><ns3:p> <ns3:bold>Methods:</ns3:bold> 208 women participated this cross-sectional 74 were resistant cases 134...
Alpha-2 Heremans Schmid Glycoprotein (AHSG) is a glycoprotein with known renoprotective role.The pathophysiology of kidney stones may be influenced by the gene's polymorphism.The purpose study to investigate potential role AHSG gene mutations in aetiology applying bioinformatics methods analyse silica analysis.Using its protein accession, IDs and their FASTA amino acid sequences, which were collected from NCBI, silico analysis SNPs was performed.The research conducted using programmes SIFT,...
Current study aims to develop a novel series of the substituted pyrimidine derivatives having anticancer potential.A were synthesized through feasible method.4-(2chloroethyl)-2,5,6-trimethylpyrimidine (3) was prepared by condensation (E)-N-(but-2-en-2-yl) acetamide (1) and 3-chloropropanenitrile (2) in presence trifluoromethanesulfonic anhydride 2chloropyridine under reflux.Amination previously generated alkyl chloride with aromatic amines triethyl amine DMF resulted formation final product...
This study aimed to investigate the relationship between UGT1A3 genetic variations and clinical outcomes, including effectiveness tolerability of sodium valproate monotherapy in pediatric patients with epilepsy.In this prospective cohort study, we enrolled one hundred epilepsy aged 2 18 years who had been receiving as sole treatment for at least month.We obtained consent from their guardians polymorphism analysis collected blood samples assess serum drug concentrations, biochemical...
Background: Studies have indicated the role of gonadal hormones in regulating structure and function nearly every tissue organ mammalian body,causing gender differences a variety characteristics.Objective our study is to compare liver tests healthy individuals find correlation between bilirubin other markers. Methodology: The retrospective was conducted by collecting data from Clinical Biochemistry Laboratory. Liver were compared among 35 women men, who got their done as part routine...