Abstract Colorectal cancer (CRC) is the third most common affecting people. The discovery of new, non-invasive, specific, and sensitive molecular biomarkers for CRC may assist in diagnosis support therapeutic decision making. Exosomal miRNAs have been demonstrated carcinogenesis development, which makes these strong CRC. Deep sequencing allows a robust high-throughput informatics investigation types abundance exosomal miRNAs. Thus, can be efficiently examined as diagnostic disease screening....

Inflammation is the main cause of several autoimmune diseases, including type I diabetes, rheumatoid arthritis, bullous pemphigoid, paraneoplastic and multiple sclerosis. Currently, there an urgent demand for discovery novel anti-inflammatory drugs with potent activity but also safe long-term application. Toward this aim, present study reported design, synthesis, characterization a set 1,3-disubstituted-2-thiohydantoins derivatives. The synthesized compounds was assessed against murine...

Purslane (Portulaca oleracea L.) is rich in phenolic compounds, protein, and iron. This study aims to produce functional yogurt with enhanced antioxidant, anticancer, antiviral, antimicrobial properties by including safe purslane extract formulation; the was preserved for 30 days at 4 °C, then biochemical fluctuations were monitored. The (PuE) had high compounds flavonoids of 250 56 mg/mL, respectively. Therefore, PuE considerable antioxidant activity, which scavenged 93% DPPH˙, inhibited...

Background Excessive levels of oxidative radicals injure organs by directly reacting with macromolecules [proteins, lipids, and deoxyribonucleic acid (DNA)]. Anti-oxidant supplements compounds rich in anti-oxidants, such as essential oils, combat radicals. Purpose This investigation aimed to assess the theory that supplementation thyme oil (TEO) basil (BEO) lessen harmful consequences hepatic stress occur when hydrogen peroxide (H 2 O ) is added drinking water. Methods Rats were randomly...

Contradictory results were obtained regarding the effects of extracellular vesicles such as exosomes (EXOs) on diabetes and diabetic nephropathy (DN). Some studies showed that EXOs, including milk involved in pathogenesis DN, whereas other revealed ameliorative effects. Compared to animals, camel had unique components lower blood glucose levels. However, little is known effect its EXOs DN. Thus, present study was conducted evaluate this a rat model DN induced by streptozotocin. Treatment...

Green synthesis of nanoparticles is receiving more attention these days since it simple to use and prepare, uses fewer harsh chemicals chemical reactions, environmentally benign. A novel strategy aims recycle poisonous plant them as natural stabilizing capping agents for nanoparticles. In this investigation, silver loaded with latex from Cynanchum acutum L. (Cy-AgNPs) were examined using a transmission electron microscope, FT-IR spectroscopy, UV-visible spectroscopy. Additionally, Vicia faba...

The food sector generates massive amounts of waste, which are rich in active compounds, especially polyphenols; therefore, valorizing these wastes is a global trend. In this study, we produce silver nanoparticles from pomegranate wastes, characterized by enhanced antioxidant, anticancer, antiviral, and antimicrobial properties investigated their potential to maintain the fruit quality for sixty days market. waste-mediated (PPAgNPs) were spherical shape (measured TEM), 20 nm (Zeta sizer),...

The green synthesis of nanoparticles (NPs) is attracting enormous attention as a new area study that encompasses the development and discovery agents for their utilization in different fields, such pharmaceuticals food. Nowadays, use plants, particularly medicinal creation NPs has emerged safe, ecofriendly, rapid, simple approach. Therefore, present aimed to Saudi mint plant silver (AgNPs) evaluate antimicrobial antioxidant activities AgNPs compared extract (ME). A phenolic flavonoid...

A novel Artemisinin/Quercetin/Zinc (Art/Q/Zn) mixed ligand complex was synthesized, tested for its antiviral activity against coronavirus (SARS-CoV-2), and investigated effect toxicity oxidative stress induced by acrylamide (Acy), which develops upon cooking starchy foods at high temperatures. The synthesized chemically characterized performing elemental analysis, conductance measurements, FT-IR, UV, magnetic XRD. morphological surface of the Art/Q/Zn using scanning transmission electron...

Valorizing the wastes of food industry sector as additives in foods and beverages enhances human health preserves environment. In this study, pomegranate pomace (PP) was obtained from company Schweppes exposed to production polyphenols fiber-enriched fractions, which were subsequently included a strawberry-yogurt smoothie (SYS). The PP is rich carbohydrates fibers has high water-absorption capacity (WAC) oil-absorption (OAC) values. LC/MS phenolic profile extract indicated that punicalagin...

Agarose (AG) is a naturally occurring biocompatible marine seaweed extract that converted to hydrocolloid gel in hot water with notable strength. Currently, its mucoadhesion properties have not been fully explored. Therefore, the main aim of this study was evaluate mucoadhesive potential AG binary dispersions combination Carbopol 934P (CP) as preparations. The gels fabricated via homogenization were evaluated for ex vivo mucoadhesion, swelling index (SI), dissolution and stability studies....

Background: Hypothyroidism has been linked to many testicular structural and dysfunctional changes in males. Thymoquinone (TQ) shown a potent protective effect through its antioxidant, anti-inflammatory, antiapoptotic, fertility-enhancing, endocrine modulatory activities. Objectives: This study aimed investigate the efficacy of TQ preserving structure model experimentally induced hypothyroidism rats identify mechanism behind this effect. Materials methods: Propylthiouracil (PTU) was used...

Background: Kidneys are among the vital organs of human body; therefore, damage from any exogenous/endogenous agent may put life at risk. Arachis hypogaea (AH) contains different free radical scavenging flavonoids, stilbenes, and tannins. This research aimed to elucidate possible nephroprotective mechanism AH methanolic crude extract (AHcr) n-hexane oil fraction (AHO) against gentamycin-induced nephrotoxicity. Methods: After extraction plant, they were tested a Gentamycin (GM)-treated group...

Sugiol, a natural compound with anticancer properties, has shown promise in various cancer types, but its potential preventing gastric remains uncertain. In this study, we aimed to examine the inhibitory effect of sugiol on human cell proliferation. Our findings demonstrate that effectively suppresses proliferation SNU-5 cells, leading apoptotic death. We assessed chemo-preventive via an MTT assay and confirmed induction oxidative stress using H2DCFDA fluorescent dye. Treatment at...

Diabetes mellitus (DM) causes an imbalance in the oxidative status of human body. Three novel Dapagliflozin (Dapg) Zn (II), Cr (III) and Se (IV) complexes were prepared characterized by elemental analysis, IR, electronic spectra, magnetic susceptibility, scanning electron microscopy (SEM) X-ray diffraction. The molar conductance values confirmed non-electrolytic nature Dapg complexes. According to spectral data, acts as a bidentate ligand. thermal analyses studied using DSC technique....

An evaluation of the ameliorative effect pomegranate peel extract (PPE) in counteracting toxicity iron oxide nanoparticles (Fe2O3-NPs) that cause hepatic tissue damage is focused on herein. Forty male albino mice were haphazardly grouped into four groups as follows: first control group was orally gavage daily with physiological saline; second received 100 mg/kg PPE by oral route day after day; third 30 Fe2O3-NPs orally; and fourth both route, same sets. Later, completion experiment, we...

The combretastatins (cis-stilbenoid molecules) have received significant interest because of their simple chemical structures, excellent antiproliferative activity, and novel anti-tubulin molecular mechanism action. Significant efforts been carried out aiming at stabilizing the active cis-isomers. A new series cis-vinylamide derivatives containing trimethoxyphenyl moiety were synthesized characterized. Their anticancer activities evaluated in vitro against MCF-7 breast cancer cell line....

This work investigated the antioxidant and hepatoprotective activities of lemongrass extract its effects on rat hepatotoxicity. The (LGE) contains bioactive components such as phenolic acids, flavonoid components, vitamin C, fibers, tannins. LGE had high content (397 mg/100g) flavonoids (164 mg/100g), influencing activity 91.25%. Additionally, it inhibited 81% breast cancer, also, growth pathogenic bacteria Candida at a concentration 20-40 µg/mL. SARS-Cov-2 by 75%; however, increasing Cas-3....

Background:Toxoplasma gondii (T. gondii) is an opportunistic parasite that causes serious diseases in humans, particularly immunocompromised individuals and pregnant women. To date, there are limited numbers of therapeutics for chronic toxoplasmosis which necessitate the discovery effective safe therapeutics. In present study, we aimed to evaluate antitoxoplasmosis potential ginger extract mice with experimentally induced toxoplasmosis. Results: Treatment significantly reduced cysts count...

The study aimed to evaluate the impact of Ficus carica mixture and Olea europaea leaf nano extracts, liraglutide, on liver tissue serum lipids in type 2 diabetic male albino rat model. Forty rats were divided equally into 4 groups used. Group 1 was non-diabetic control group. animals Groups 2-4 injected intraperitoneally with a single dose 60 mg/kg b.w. Streptozotocin induce served as positive for diabetes. 0.02 b.w./day Liraglutide gave 3 4.8 ng/ml × 105 respectively. Eight weeks after...

Green nanotechnology has attracted attention worldwide, especially in treating cancer and drug-resistant section 6 microbes. This work aims to investigate the anticancer activity of green silver nanoparticles synthesized by Spirulina platensis phycocyanin (SPAgNPs) on two cell lines: Lung line (A-549) breast (MCF-7), compared normal human lung (A138). We also aimed bactericidal against Staphylococcus aureus ATCC29737, Bacillus cereus ATCC11778, Escherichia coli ATCC8379, Klebsiella...

Oral squamous cell carcinoma (OSCC) is the most common epithelial tumor of oral cavity. Gingival tumors, a unique type OSCC, account for 10% these malignant tumors. The antineoplastic properties statins, including pitavastatin (PV), and essential oil Pinus densiflora leaf (Pd oil) have been adequately reported. goal this investigation was to develop nanostructured lipid carriers (NLCs) containing PV combined with Pd determine their cytotoxicity against line human gingival fibroblasts...

The current study was designed to formulate ternary solid dispersions (TSDs) of dexibuprofen (Dex) by solvent evaporation augment the solubility and dissolution profile, in turn providing gastric protection effective anti-inflammatory activity. Initially, nine formulations (S1 S9) binary (BSDs) were developed. Formulation S1 comprising a 1:1 weight ratio Dex Syloid 244FP® chosen as optimum BSD formulation due its better profile. Afterward, 20 TSD developed using BSD. containing with 40%...