A5049534252- Phytochemicals and Antioxidant Activities
- Computational Drug Discovery Methods
- Nanoparticle-Based Drug Delivery
- RNA regulation and disease
- Viral-associated cancers and disorders
- Pomegranate: compositions and health benefits
- SARS-CoV-2 and COVID-19 Research
- Traditional and Medicinal Uses of Annonaceae
- Antioxidants, Aging, Portulaca oleracea
- Hydrogen's biological and therapeutic effects
- Research on Leishmaniasis Studies
- Medicinal Plants and Bioactive Compounds
- Plant-Derived Bioactive Compounds
- Genomics and Rare Diseases
- Phytochemistry Medicinal Plant Applications
- Natural Antidiabetic Agents Studies
- Genomics, phytochemicals, and oxidative stress
- Parvovirus B19 Infection Studies
- Sulfur Compounds in Biology
- Plant biochemistry and biosynthesis
- Neuroinflammation and Neurodegeneration Mechanisms
- Graphene and Nanomaterials Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Advanced biosensing and bioanalysis techniques
- Protein Hydrolysis and Bioactive Peptides
King Abdulaziz University
2015-2023
Dietary medicinal plants are among the most sought-after topics in alternative medicine today due to their preventive and healing properties against many diseases.This study aimed extract determine polyphenols from indigenous extracts, i.e., Mentha longifolia, M. arvensis, Tinospora cordifolia, Cymbopogon citratus, Foeniculum vulgare, Cassia absus, Camellia sinensis, Trachyspermum ammi, C. sinensis then evaluate antioxidant, cytotoxicity, antimicrobial properties, besides enzyme inhibition...
Purslane (Portulaca oleracea L.) is rich in phenolic compounds, protein, and iron. This study aims to produce functional yogurt with enhanced antioxidant, anticancer, antiviral, antimicrobial properties by including safe purslane extract formulation; the was preserved for 30 days at 4 °C, then biochemical fluctuations were monitored. The (PuE) had high compounds flavonoids of 250 56 mg/mL, respectively. Therefore, PuE considerable antioxidant activity, which scavenged 93% DPPH˙, inhibited...
Gymnema sylvestre (GS) is a perennial woody vine native to tropical Asia, China, the Arabian Peninsula, Africa and Australia. GS has been used as medicinal plant with potential anti-microbial, anti-inflammatory anti-oxidant properties. This study was conceptualized evaluate cytotoxicity of saponin rich fraction (GSSRF) on breast cancer cell lines (MCF-7 MDA-MB-468) by SRB assay. The anti-tumor activity GSSRF assessed in tumor-bearing Elrich ascites carcinoma (EAC) Dalton's lymphoma (DLA)...
Valorizing the wastes of food industry sector as additives in foods and beverages enhances human health preserves environment. In this study, pomegranate pomace (PP) was obtained from company Schweppes exposed to production polyphenols fiber-enriched fractions, which were subsequently included a strawberry-yogurt smoothie (SYS). The PP is rich carbohydrates fibers has high water-absorption capacity (WAC) oil-absorption (OAC) values. LC/MS phenolic profile extract indicated that punicalagin...
Industrial pomaces are cheap sources of phenolic compounds and fibers but dumping them in landfills has negative environmental health consequences. Therefore, valorizing these wastes the food industry as additives significantly enhances final product. In this study, citrus pomaces, orange pomace (OP), mandarin (MP), lemon (LP) were collected by a juice company subjected to producing polyphenols fiber-enriched fractions, which included functional yogurt; powder with different levels (1, 3,...
Triple-negative breast cancer (TNBC) subtype is characterized by aggressive clinical behavior and poor prognosis patient outcomes. Here, we show that ADAR1 more abundantly expressed in infiltrating (BC) tumors than benign tumors. Further, protein expression higher BC cells (MDA-MB-231). Moreover, identify a novel interacting partners proteins list with MDA-MB-231, using immunoprecipitation assay mass spectrometry. Using iLoop, protein-protein interaction prediction server based on structural...
Green nanotechnology has attracted attention worldwide, especially in treating cancer and drug-resistant section 6 microbes. This work aims to investigate the anticancer activity of green silver nanoparticles synthesized by Spirulina platensis phycocyanin (SPAgNPs) on two cell lines: Lung line (A-549) breast (MCF-7), compared normal human lung (A138). We also aimed bactericidal against Staphylococcus aureus ATCC29737, Bacillus cereus ATCC11778, Escherichia coli ATCC8379, Klebsiella...
The majority of human tumors are characterized by abnormal signaling caused oncogenic RAS proteins. KRAS is a member the family and currently one most thoroughly researched targets for cancer treatment due to its prevalence in variety deadly malignancies. Targeting protein, which plays crucial role regulating cell growth, differentiation, apoptosis, shows great potential as strategy fighting cancer. Herein, silico screening 530 natural compounds against protein was performed. top-scoring...
Kaposi’s sarcoma associated herpesvirus (KSHV) is causative agent of sarcoma, Multicentric Castleman Disease and Pleural effusion lymphoma. KSHV-encoded ORF17 encodes a protease which cleaves -Ala-Ala-, -Ala-Ser- or -Ala-Thr-bonds. The plays an important role in assembly maturation new infective virions. In the present study, we investigated expression pattern during physiologically allowed as well chemically induced reactivation condition. results showed direct proportionate relationship...
Neurodevelopmental disorders (NDDs) are classified as a group of affecting function and development the brain having wide clinical variability. Herein, we describe two affected individuals segregating recessive NDD. The exhibited phenotypes such global developmental delay (GDD), intellectual disability (ID), microcephaly speech delay. Whole-exome sequencing (WES) followed by bidirectional Sanger techniques identified homozygous nonsense variant (c.466C > T; p.Gln156*) in PPFIBP1 gene...
Breast cancer is the most prevalent among women and considered a societal burden. The current treatment strategies are limited to chemotherapy, radiotherapy, surgery, governed by tumor's size, stage, properties of biomarkers. Nanotechnology can be used as an alternative focused approach for treating various cancers. It provides more effective less toxic regime than other conventional methods. has gained enormous attention precisely diagnose treat Nanocarriers ideally engineered target cells...
Although Annona squamosa Linn. (Annonaceae) has been used in traditional medicine and is known to have several pharmacological properties, its impact on EGFR kinase not fully investigated. An assay (biochemical) was govern the potential of different A. seed extracts scavenge free radicals petroleum ether, acetone, ethanol, methanol. We also tested leaf for their ability inhibit growth HEK 293, MCF7, HepG2 cell lines. The PSE, ASE, ESE, MSE all contained anti-cancer substances like anethole,...
Neutrophils are essential components of the immune system and have a critical role in combating bacterial fungal infections.A key weapon neutrophil armory is "respiratory burst," which generation reactive oxygen species (ROS) by multicomponent oxidase complex.It well established that preexposure human neutrophils to proinflammatory cytokines chemokines markedly augments production subsequent stimuli.In inflammatory reactions, there complex interactions protein mediators (cytokines) derived...
The negative effects of leishmanicidal medications are numerous, and drug resistance to all them has been observed. As a result, new medication development the identification novel therapeutic targets critical. Leishmania major trypanothione reductase (Lm-TR), NADPH-dependent flavoprotein oxidoreductase critical for thiol metabolism, is required parasite viability. Since it lowers trypanothione, chemical by Leishmania's tryparedoxin/tryparedoxin peroxidase system neutralise hydrogen peroxide...
Purpose: To investigate the effect of ethanol seed extract (SE) on pancreatic function markers associated with streptozotocin-induced diabetes in rats.
 Methods: Non-diabetic rats (n = 12) were divided into 2 groups (GRPs); GRP1 served as control, and GRP2 was administered orally V. vinifera SE (500 mg/kg). Diabetic GRPs; GRP3 diabetic rats, GRP4 received Blood collected at end 4 weeks, serum glucose lipid profile measured using colorimetric enzymatic kits. Serum insulin, interleukin-1...
The pandemic that started in 2020 left us with so much information about viruses and respiratory diseases, the cause behind it was severe acute syndrome coronavirus-2 (SARS CoV-2). world is still recovering, which costs many economic other indirect disasters; despite that, no medications are available on market. Although WHO approved a few vaccines an emergency basis, remarks reinfection chances under investigation, pharmaceutical companies also claiming can be effective. However, there...