A5003878678- Computational Drug Discovery Methods
- Pharmacological Effects of Natural Compounds
- Cancer therapeutics and mechanisms
- Phytase and its Applications
- Moringa oleifera research and applications
- Carcinogens and Genotoxicity Assessment
- Legume Nitrogen Fixing Symbiosis
- Melanoma and MAPK Pathways
- Chemotherapy-induced organ toxicity mitigation
- Ion channel regulation and function
- Aquaculture Nutrition and Growth
- Metal complexes synthesis and properties
- Cell death mechanisms and regulation
- Cholinesterase and Neurodegenerative Diseases
- Phytochemical compounds biological activities
- Epigenetics and DNA Methylation
- Substance Abuse Treatment and Outcomes
- Pharmacological Effects of Medicinal Plants
- Pesticide Exposure and Toxicity
- Protein Kinase Regulation and GTPase Signaling
- Natural product bioactivities and synthesis
- Medicinal Plant Pharmacodynamics Research
- Biological Research and Disease Studies
- Cardiac electrophysiology and arrhythmias
- Retinoids in leukemia and cellular processes
University of Jeddah
2022-2024
University of Birmingham
2020-2021
Outdoor air pollution is a significant environmental health concern, linked to chronic respiratory diseases, heart conditions, and immunosuppression. One common indoor pollutant Bakhour, fragrant incense burned in many homes. Despite its widespread use, little research has explored the potential risks associated with Bakhour smoke exposure. This study investigated toxic effects of on immune system. Three popular types (Oud, Mabthoth, Mastic) were for four hours daily two weeks, exposing 20...
The study aims to describe phageome of soil rhizosphere M.oleifera in terms the genes encoding CAZymes and other KEGG enzymes.Genes rhizospheric virome wild plant species Moringa oleifera were investigated for their ability encode useful (Kyoto Encyclopedia Genes Genomes) enzymes resist antibiotic resistance (ARGs) soil.Abundance these was higher microbiome than bulk soil. Detected viral families include family Potyviridae as well tailed bacteriophages class Caudoviricetes that are mainly...
Fish represent an excellent source of animal protein as well a biomedical research model result their evolutionary relatedness and similarity with the human genome. Commercial ornamental fish culture has achieved popularity, but reproductive dysfunctions act limiting factor for quality fry production, interfering sustainability aquaculture industry. reproduction is crucial any species’ existence, performance can potentially be improved through applications epigenetics probiotics. Epigenetics...
Cervical Cancer (CC) is one of the most common types cancer in women worldwide, with a significant number deaths reported yearly. Despite various treatment options available, high mortality rate associated CC highlights need to develop new and effective therapeutic agents. In this study, we have screened complete prepared FDA library against Mitotic kinesin-like protein 1, Cyclin B1, DNA polymerase, MCM10-ID using three glide-based molecular docking algorithms: HTVS, SP XP produce robust...
Overexpression of the epidermal growth factor receptor (EGFR) has been shown to be a critical in tumor development and cancer progression. Although established EGFR inhibitors have effective treatment cancer, they are associated with several side effects. As result, there is an urgent need develop novel that can effectively target while causing no adverse Here, bioactive compounds Glycyrrhiza glabra screened against catalytic site. The LTS0058805, LTS0114552, LTS0128805, LTS0174203,...
Alzheimer's disease (AD) is a neurological that related to aging and the leading cause of dementia globally. AD has significant influence on cognitive functions, particularly memory, resulting in variety functional deficits. Given increasing prevalence AD, there an urgent need for development effective therapeutic therapies. In quest uncover holistic remedy total 41 bioactive compounds derived from three distinct medicinal plant sources were screened evaluate their potential inhibit active...
The majority of human tumors are characterized by abnormal signaling caused oncogenic RAS proteins. KRAS is a member the family and currently one most thoroughly researched targets for cancer treatment due to its prevalence in variety deadly malignancies. Targeting protein, which plays crucial role regulating cell growth, differentiation, apoptosis, shows great potential as strategy fighting cancer. Herein, silico screening 530 natural compounds against protein was performed. top-scoring...
Doxorubicin (DOX) is a potent anticancer drug, which can have unwanted side-effects such as cardiac and kidney toxicity. A detailed investigation was undertaken of the acute cytotoxic mechanisms DOX on cells, using Cos-7 cells cell model. were exposed to for period 24 h over range concentrations, LC50 determined be 7 µM. Further investigations showed that death mainly via apoptosis involving Ca2+ caspase 9, in addition autophagy. Regucalcin (RGN), cytoprotective protein found liver tissues,...
The Government of Saudi Arabia has recognized and acknowledged substance abuse as a public health problem. As aresult, specialized hospitals have been established in many regions to treat abuse. prevalence was investigated using sample 197 patients at Al-Amal Hospital, Riyadh, during period four months starting from May August 2018. mean age the study 26.5 years. proportionof based on substances abused were follows: amphetamines (30.9%), cannabis (30.1%), ethyl alcohol (22.9%), alprazolam...
Neuroblastomas usually occur in childhood and can have a relatively poor prognosis. Additionally, some antipsychotic drugs been suggested to be neurotoxic, suggesting they might therapeutic potential against neuronal cancer cells. In this study it was shown that 7 days treatment with 10 µM all-trans retinoic acid (ATRA) could alter SH-SY5Y (an undifferentiated neuroblastoma cell line) morphology terms of neurite outgrowths increased expression the growth associated protein (GAP43), thus...
The current study was conducted on workers in the printing industry Addis Ababa, capital and largest city of Ethiopia, which has grown significantly recent years, providing work for a large number people whose health motivates us to carry out this work. Because these handle substances that appear innocuous but are toxic human health, such as paint products like VOCs, inhaling volatile organic solvents is involuntary. If chronic, it manifests various symptomatic forms humans, changes...
According to the research, there are many illnesses for which therapeutic mineral hot springs employed as an alternative. Its physicochemical characteristics have a substantial body of evidence. The in vivo antioxidant effect Mosul's Iraq has been investigated current investigation. An experimental design toxicity, control group, and study group were created. In addition, Mosul, Iraq, studied by lipid antiperoxidation method with (p < 0.05), vitro free radical scavenging (DPPH) its...
Chemicals from Pharmaceuticals and Personal Care Products (PPCPs) have become much more prevalent in the environment recent years. The effects of these substances on human health are frequently debatable because they typically poorly understood mechanisms toxic action. For this reason, we set out to evaluate a binary mixture consisting butylhydroxyanisole (BHA) propylparaben (PPB), two approved additives that been found range health-related effects. Based our prior research, chose an...
Metagenomic approach was used to detect microbial gene abundance and relative in the rhizosphere of Moringa oleifera surrounding bulk soil response microbes watering. Expectedly, number non-redundant genes were extremely higher bacteria followed by archaea, eukaryota viruses. Results demonstrated unexpected high some (ex., endophyte genus Nocardioides) that are supposed exist mainly other rhizocompartments. We suggest this differential distribution is due specific pattern host-microbe...