A5006078168- Computational Drug Discovery Methods
- vaccines and immunoinformatics approaches
- SARS-CoV-2 and COVID-19 Research
- Epigenetics and DNA Methylation
- Viral Infections and Outbreaks Research
- Synthesis and biological activity
- Viral Infections and Vectors
- Pharmacological Effects of Natural Compounds
- Bioinformatics and Genomic Networks
- Cholinesterase and Neurodegenerative Diseases
- Mosquito-borne diseases and control
- Aquaculture disease management and microbiota
- Ubiquitin and proteasome pathways
- Aquaculture Nutrition and Growth
- Identification and Quantification in Food
- Virology and Viral Diseases
- Lung Cancer Treatments and Mutations
- Drug Transport and Resistance Mechanisms
- Ethnobotanical and Medicinal Plants Studies
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- TGF-β signaling in diseases
- Advanced biosensing and bioanalysis techniques
- Polyomavirus and related diseases
- RNA and protein synthesis mechanisms
Hamad bin Khalifa University
2022-2025
King Abdulaziz University
2020-2023
University of Science and Technology
2022
International Islamic University Malaysia
2019
X-linked inhibitor of apoptosis protein (XIAP) is a member (IAP) family responsible for neutralizing the caspases-3, caspases-7, and caspases-9. Overexpression decreased process in cell resulting development cancer. Different types XIAP antagonists are generally used to repair defective that can eliminate carcinoma from living bodies. The chemically synthesis compounds discovered till now as inhibitors exhibiting side effects, which making difficulties during treatment chemotherapy. So,...
Ongoing COVID-19 outbreak has raised a drastic challenge to global public health security. Most of the patients with suffer from mild flu-like illnesses such as cold and fever; however, few percentages progress severe illness death, mostly in an immunocompromised individual. The causative agent is RNA virus known acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite these debilitating conditions, no medication stop disease progression or vaccination available till now. Therefore, we...
Minichromosome maintenance complex component 7 (MCM7) belongs to the minichromosome family that is important for initiation of eukaryotic DNA replication. Overexpression MCM7 protein relative cellular proliferation and responsible aggressive malignancy in various cancers. Mechanistically, inhibition significantly reduces associated with cancer. To date, no effective small molecular candidate has been identified can block progression cancer induced by protein. Therefore, study designed...
Walleye dermal sarcoma virus (WDSV) is a type of retrovirus, which affects most the adult walleye fishes during spawning time. The causes multiple epithelial tumors on fish’s skin and fins that are liable for more than 50% mortality rate fish around world. Till now, no effective antiviral drug or vaccine candidates have been developed can block progression disease caused by pathogen. It was found 582-amino-acid (aa) residues long internal structural gag polyprotein plays an important role in...
Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly infectious zoonotic virus first reported into the human population in September 2012 on Arabian Peninsula. The causes severe and often lethal illness humans with an unusually high fatality rate. N-terminal domain (NTD) of receptor-binding S1 subunit spike (S) proteins can recognize variety host protein mediates entry cells. Blocking by targeting S1-NTD facilitate development effective antiviral drug candidates against...
Pancreatic cancer is a very deadly disease with 5-year survival rate, making it one of the leading causes cancer-related deaths globally. Focal adhesion kinase 1 (FAK1) ubiquitously expressed protein in pancreatic cancer. FAK, tyrosine that overexpressed cells, crucial for development tumors into malignant phenotypes. FAK functions response to extracellular signals by triggering transmembrane receptor signaling, which enhances focal turnover, cell adhesion, migration, and gene expression....
Abstract Aquaculture is now the main source of seafood in human diets and one its fastest‐growing industries worldwide. However, industry facing several difficulties, including infectious diseases, most significant limiting factor for aquaculture expansion. The impact diseases on growth, fecundity, mortality rates, marketability profound. Hence, ability to predict disease outbreaks crucial overcoming these challenges. Various agents such as bacteria, viruses, fungi, parasites can cause...
Rearranged during transfection (RET), an oncogenic protein, is associated with various cancers, including non-small-cell lung cancer (NSCLC), papillary thyroid (PTC), pancreatic cancer, medullary (MTC), breast and colorectal cancer. Dysregulation of RET contributes to development, highlighting the importance identifying lead compounds targeting this protein due its pivotal role in progression. Therefore, study aims discover effective across different types evaluate their potential inhibit
Colorectal cancer (CRC) is the second most common cause of death worldwide, affecting approximately 1.9 million individuals in 2020. Therapeutics disease are not yet available and discovering a novel anticancer drug candidate against an urgent need. Thymidylate synthase (TS) important enzyme prime precursor for DNA biosynthesis that catalyzes methylation deoxyuridine monophosphate (dUMP) to deoxythymidine (dTMP) has emerged as target disease. Elevated expression TS proliferating cells...
Transporter associated with antigen processing 1 (TAP1) is a transporter protein that represent tumor in the MHC I or HLA complex. Any defect TAP1 gene resulting inadequate tracking. influences multidrug resistance (MDR) human cancer cell lines and hinders treatment during chemotherapeutic. The association of progression remains mostly unknown further study relation need to conduct. Thus, has designed analyze between by computationally. expression pattern determined using ONCOMINE, GENT2,...
Abstract Background Crimean-Congo hemorrhagic fever (CCHF) is a widespread disease transmitted to humans and livestock animals through the bite of infected ticks or close contact with persons’ blood, organs, other bodily fluids. The virus responsible for severe viral outbreaks, case fatality rate up 40%. Despite having highest virus, suitable treatment option vaccination has not been developed yet. Therefore, this study aimed formulate multiepitope vaccine against CCHF computational design...
The etiology of cervical cancer in women is attributed to the continuous infection human papillomavirus (HPV). high costs and side effects standard treatments limited efficacy HPV vaccination have led a quest for novel, cost-effective treatments, particularly middle- low-income countries. Therefore, our objective was evaluate capacity marine seaweed compounds hinder activity E6 Oncoprotein. Seaweed Metabolite Database evaluated its ability inhibit Oncoprotein functions by throughput virtual...
The study was designed to investigate the qualitative phytochemical constituents and evaluate anti-inflammatory, anti-nociceptive anti-diarrhoeal activities of methanol (MHAL) ethyl acetate (EAHAL) extract Hemigraphis alternata leaves in Swiss albino mice. Qualitative MHAL EAHAL were determined by different tests such as Molisch's test, Fehling Mayer's Frothing FeCl3 Alkali Salkowski's Keller-killiani test CuSO4 test. In addition, Xylene induced-ear edema Cotton pellet-induced granuloma...
Minichromosome maintenance protein 2 (MCM2) is a highly conserved from the MCM family that plays an important role in eukaryotic DNA replication as well cell cycle progression. In addition, it maintains ploidy level consistency cells, hence, mutations or alteration of this could result disintegration fine-tuned molecular machinery can lead to uncontrolled proliferation. Moreover, MCM2 has been found be marker for progression and prognosis different cancers. Therefore, we aimed analyze...
SARS-CoV-2 is an etiologic agent responsible for the coronavirus disease 2019 (COVID-19) pandemic. The virus has rapidly extended globally and taken millions of lives due to unavailability therapeutics candidates against virus. Till now, no specific drug have been developed that can prevent or treat infections caused by pathogen. main protease (Mpro) plays a pivotal role in mediating viral replication mechanistically inhibition protein hinder infection process Therefore, study aimed identify...
Merkel cell carcinoma (MCC) is a rare neuroendocrine skin malignancy caused by human polyomavirus (MCV), leading to the most aggressive cancer in humans. MCV has been identified approximately 43%–100% of MCC cases, contributing highly nature primary cutaneous and notable mortality rate. Currently, no existing vaccines or drug candidates have shown efficacy addressing ailment this specific pathogen. Therefore, study aimed design novel multiepitope vaccine candidate against virus using...