Nanotechnology and nanoparticles (NPs) have increasingly been studied as an alternative for antibiotics because of the feasibility to be used in implantable devices both bacterial detection infection prevention. The low rate resistance development against NPs its multiple mode action has contributed increased acceptance clinical setting. Further their anticancer activity many human cancer cell lines including breast ovarian documented. Fe2O3-NPs could antibacterial assessment. Iron oxide,...

We aimed to explore perceptions, attitudes and practices toward research among medical students. A self-administered questionnaire was distributed senior students at the King Saud University, Riyadh, Saudi Arabia. Hundred seventy two participated in study, with 97 males (65.5%). The majority of agreed that is important field (97.1%, 167/172). total 67.4% (116/172) believed conducting should be mandatory for all During school, 55.3% (88/159) research. obstacles prevented from included lack...

Minichromosome maintenance complex component 7 (MCM7) belongs to the minichromosome family that is important for initiation of eukaryotic DNA replication. Overexpression MCM7 protein relative cellular proliferation and responsible aggressive malignancy in various cancers. Mechanistically, inhibition significantly reduces associated with cancer. To date, no effective small molecular candidate has been identified can block progression cancer induced by protein. Therefore, study designed...

Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly infectious zoonotic virus first reported into the human population in September 2012 on Arabian Peninsula. The causes severe and often lethal illness humans with an unusually high fatality rate. N-terminal domain (NTD) of receptor-binding S1 subunit spike (S) proteins can recognize variety host protein mediates entry cells. Blocking by targeting S1-NTD facilitate development effective antiviral drug candidates against...

Hyperhidrosis (HH) is characterized by excessive sweating, which can significantly affect quality of life. The Quality Life Index (HidroQoL©) the latest tool that has been developed and validated for assessing life patients with HH. Because absence an Arabic version HidroQoL©, this research aimed to create, validate, adapt HidroQoL© into Arabic. A quantitative, analytical, cross-sectional study was conducted HH followed up in dermatology or thoracic surgery clinics. We assessed results...

Centaurea calcitrapa has been intensively utilized in ethnomedicinal practices as a natural therapeutic recipe to cure various ailments. The current study aimed chemically characterize ethanolic extract of C. (EECC) aerial parts (leaves and shoots) by use gas chromatography-mass spectrometry analyses (GC-MS) investigate its antioxidant vitro anticancer activities, elucidating the underlying molecular mechanism flow cytometry-based fluorescence-activated cell sorting (FACS) conducting silico...

Background: Many international studies have been conducted to assess the knowledge, attitudes and practices (KAP) of public toward sun exposure sun-protection measures. However, there are scarce data on these factors from Middle East. Objectives: This study aimed explore KAP measures among Saudis. Methods: A cross-sectional survey using a specially designed questionnaire was stratified random sample general population in five geographical regions Saudi Arabia (central, eastern, northern,...

Background: Hyperhidrosis (HH) is characterized by excessive sweating, which affects quality of life. The Disease Severity Scale (HDSS) a four-point scale used to evaluate HH severity measuring how much sweating disrupts daily activities. This study aimed translate, validate, and adapt the HDSS tool into Arabic. Methods: A quantitative, analytical, cross-sectional was carried out from May June 2024 on patients clinically diagnosed with HH. process translating Arabic involved three...

Although the practice of bleaching is common worldwide, there are few studies that discuss knowledge, attitudes and practices towards bleaching.The aim this study was to explore usage topical agents among women.A self-administered questionnaire on use creams distributed randomly women attending outpatient clinics at a university hospital in Saudi Arabia during 2008.Five hundred nine 620 responded (82% response rate). All participants had dark skin (skin type 4-5). The mean age 29.22 ± 9...

Background Until now, segmental vitiligo has been considered as a stable entity and mixed vitiligo, the association of nonsegmental reported rarely. Objectives The aim this study was to search for factors associated with generalization in patients vitiligo. Patients methods This prospective observational conducted clinic Department Dermatology Bordeaux, France. Vitiligo European Task Force questionnaire completed each patient attending confirmed diagnosis after exclusion other forms (focal,...

Abstract Background As the use of Internet increases, it is important to gain insight into how used by patients obtain health‐related information. Objectives We aimed explore attitudes and practices dermatology outpatients regarding their find health also investigate consequences this on patient–doctor relationship. Methods A self‐administered questionnaire was given adult attending Dermatology Department at King Saud University, Riyadh, Saudi Arabia, from January June 2008. Results total...

Patients' beliefs about their illness can result in positive and/or negative implications for the management of disease. To examine held by vitiligo patients condition and to explore potential factors that might influence such beliefs.The perception questionnaire (IPQ) was translated into particular regional language (Arabic) administered adult visiting our Dermatology Department, from 2006 2008. Demographic details were obtained.We recruited 164 (91 male subjects). The mean age 27 years (SD...

Vitiligo is a cutaneous disorder characterized by depigmented macules on the skin due to loss of melanocytes from epidermal basal layer. It among most common worldwide prevalent disorders. Various factors are implicated which autoimmunity widely acknowledged for melanocyte destruction in vitiligo. Genetic predisposition conferred susceptibility loci region encoding several immunoregulatory genes has been suggested contribute onset and progression Herein, we provide an overview current...

Oral anticancer therapy mostly faces the challenges of low aqueous solubility, poor and irregular absorption from gastrointestinal tract, food-influenced absorption, high first-pass metabolism, non-targeted delivery, severe systemic local adverse effects. Interest has been growing in bioactive self-nanoemulsifying drug delivery systems (bio-SNEDDSs) using lipid-based excipients within nanomedicine. This study aimed to develop novel bio-SNEDDS deliver antiviral remdesivir baricitinib for...

The treatment of periungual warts is a therapeutic challenge. Various modalities can be ineffective and may cause scarring permanent nail changes.A prospective pilot study to investigate the efficacy safety low concentration (0.1 U/mL) bleomycin in warts.Periungual were injected with every 4 weeks until elimination lesions or injections discontinued because adverse effects. Bleomycin was administered using translesional multipuncture technique.We recruited 15 patients from March 2007 2008....

Background: Previous studies have discussed attitudes of vitiligo patients toward their disease. However, no addressed this issue from the public's point view. Objective: To explore perceptions, attitudes, and misconceptions public vitiligo. Methods: A self-administered questionnaire was distributed to attendees primary health care centers in Riyadh, Saudi Arabia, between January August 2010. Results: Overall, 924 1,000 questionnaires were returned, 429 males (46.8%). Moreover, 33.1% (303...

Background: Low vitamin D levels have been associated with several autoimmune diseases. Vitiligo could be low levels. Objective: To determine the level of serum in vitiligo patients compared to controls and reveal possible association pathogenesis vitiligo. Patients Methods: A case-controlled study was conducted. After excluding factors that may affect levels, blood samples were taken from controls. The between various subgroups (duration vitiligo, site onset, age, etc) measured correlated....

Nano-erythrocyte coating has been developed as an interesting biomimetic platform to provide hybrid nano-carriers with innate functions target liver cancer. This goal was achieved by nano-erythrocyte membranes (NEMs) onto 5-fluorouracil (5-FU)-loaded liposomes (LPs) produce NEM-5-FU-LPs. framework is used promote the escape of 5-FU-LPs from degradation during systemic circulation. NEMs were obtained hypotonic lysis erythrocytes ghost (GEs) followed extrusion through polycarbonate membranes....