Fulminant hepatic failure (FHF) is clinical syndrome with very poor prognosis and high mortality there urgent need for the development of safe non-toxic hepatoprotective agents adequate management hepatitis. Hepatoprotective effect Lepidium sativum ethanolic extract (LSEE) was assessed by D-galactosamine-induced/lipopolysaccharide (400 mg/kg 30 μg/kg) liver damage model in rats.Hepatoprotective activity LSEE (150 300 mg/kg) silymarin on D-GalN/LPS induced FHF rat using several function...

Clinical multi-drug-resistant bacteria continue to be a serious health problem. Plant-derived molecules are an important source of bioactive compounds counteract these pathogenic bacteria. In this paper, we studied the chemical composition methanol (80%) extract from Pithecellobium dulce seed (Hail, Saudi Arabia) and its ability inhibit growth clinically relevant Molecular docking analysis was performed predict best with low binding energy high affinity interact two Staphylococcus aureus...

Wheat germ oil (WGO) is the richest source of unexplored antioxidants and anti-inflammatory compounds. In this study, we identified constituents WGO by gas chromatography-mass spectrometry (GC-MS). The physicochemical pharmacokinetic behaviors were evaluated for top 12 with common target FABP4. Three fatty acids significant activity their interaction FABP4 molecular docking. mechanisms involved in responses analyzed various in-silico analytical tools multidimensional data analysis. showed...

Recent studies from the author's laboratory indicated that camel urine possesses antiplatelet activity and anti-cancer which is not present in bovine urine. The objective of this study to compare volatile elemental components using GC-MS ICP-MS analysis. We are interested know component performs these biological activities. freeze dried was dissolved dichloromethane then derivatization process followed by BSTFA for Thirty different compounds were analyzed full scan mode. For analysis twenty...

Abstract Neurodegenerative diseases (Alzheimer’s, Parkinson’s etc.) causes brain cell damage leading to dementia. The major restriction remains in delivering drug the central nervous system is blood barrier (BBB). aim of this study was develop a liposomal delivery Aphanamixis polystachya leaf extract for treatment neurodegenerative such as Alzheimer’s and disease. In GC-MS analysis used determine constituents extract. Liposomal batches prepared using design experiment (DoE) characterized...

Inflammation is responsible for the development of many diseases that make up a significant cause death. The purpose study was to develop novel nanophytosomal preparation epigallocatechin-3-gallate (EGCG) and egg phospholipid complex has lower particle size with higher drug loading capability, physical stability anti-inflammatory activities. impact different factors material characteristics on average studied along phytosome using design experiment (DoE). in vivo evaluated rat model...

Oral anticancer therapy mostly faces the challenges of low aqueous solubility, poor and irregular absorption from gastrointestinal tract, food-influenced absorption, high first-pass metabolism, non-targeted delivery, severe systemic local adverse effects. Interest has been growing in bioactive self-nanoemulsifying drug delivery systems (bio-SNEDDSs) using lipid-based excipients within nanomedicine. This study aimed to develop novel bio-SNEDDS deliver antiviral remdesivir baricitinib for...

The aim of the present investigation was to explore constituents Arabian myrrh resin obtained from Commiphora myrrha. organic and inorganic composition gum has been investigated using gas chromatography-mass spectrometry (GC-MS) inductively coupled plasma-mass (ICP-MS). Analysis executed by ICP-MS reveals presence various elements in significant amount resin. that were found be large amounts include calcium, magnesium, aluminum, phosphorus, chlorine, chromium, bromine scandium. important...

Background and Objectives: Ficus benghalensis (FB) is a commonly found tree in Pakistan its various parts have folkloric importance managing neurological ailments. In the present study, methanolic extract of bark has been tested on an experimental animal model to evaluate memory-enhancing, anxiolytic antidepressant activities validate claimed therapeutic potential. Materials Methods: Methanolic freshly isolated was prepared subjected preliminary phytochemical studies gas chromatography–mass...

Ever increasing spread of drug resistance among bacterial pathogens have rendered the current antibiotic therapy ineffective. Drug-resistant urinary tract infections caused by Gram negative such as Pseudomonas aeruginosa, Escherichia coli, Acinetobacter baumannii, and Serratia marcescens are considered more severe life threatening because strong biofilm dependent growth characteristics majority them. Moreover, most uropathogens coordinate their complex virulence responses via a highly...

Fentanyl is a highly potent opioid analgesic that approved medically to treat acute and chronic pain. There high potential for overdose-induced organ toxicities, including liver toxicity, this might be due the increase of recreational use opioids. Several preclinical studies have demonstrated efficacy beta-lactams in modulating expression glutamate transporter-1 (GLT-1) different body organs, liver. The upregulation GLT-1 by associated with attenuation hyperglutamatergic state, which...

We evaluated the in vitro antioxidant and antimicrobial potential of Schimpera arabica extract fractions (2-Hexadecen-1-ol beta sitosterol).Free radical scavenging activity was estimated by using ABTS DPPH methods, reducing power iron chelation studied to investigate extracts. Well-diffusion method utilized evaluate Gas chromatography-mass spectroscopy analysis revealed presence 27 compounds. Phenolic flavonoid contents were found high amount (7·6-18 mg GAE, g-1 ; 3·2-10·8 catechin, ) dry...

Tarchonanthus Camphoratus L. is traditionally known for its various medicinal purposes. In this study, the T. camphoratus essential oil (TCEO) was isolated via steam distillation, and chemical constituents were determined using GC-MS. The in vitro antiproliferative effects of TCEO on A549, HepG2, MCF-7 cancer cells, HUVEC non-tumor cells investigated an MTT assay. Flow cytometry analysis conducted to evaluate cell cycle distribution propidium iodide staining, death mode Annexin V-FITC/PI...

Studies have demonstrated that chronic consumption of abused drugs induces alterations in several proteins regulate metabolism. For instance, methamphetamine exposure reduces glucose levels. Fatty and amino acid levels were altered groups exposed to drugs. Therefore, our study, we investigated the serum metabolomic profile patients diagnosed with cannabis and/or amphetamine use disorders. Blood was obtained from subjects (control, amphetamine, cannabis). Detection metabolites performed using...

Garlic's main bioactive organosulfur component, diallyl trisulfide (DATS), has been widely investigated in cancer models. However, DATS is not suitable for clinical use due to its low solubility. The current study seeks improve bioavailability and assess chemopreventive chemosensitizing properties an AOM-induced colorectal model. polyethylene glycol coated Distearoylphosphatidylcholine/Cholesterol (DSPC/Chol) comprising DATS-loaded DATSL doxorubicin (DOXO)-encapsulated DOXL liposomes was...

Abstract The medicinal plant Haloxylon salicornicum is utilized for therapeutic purposes. We previously reported the antioxidant potential of hexane fraction and methanol extracts same species. However, since these solvents could be clinically toxic, current findings investigated pharmacological effects water fraction. pain relieving, antioxidant, anti-inflammatory, antipyretic H. extract (HEW) were studied at two concentrations (250 500 mg/kg) in rodents. carrageenan stimulated rat paw...

Diallyl disulfide (DADS) is one of the main bioactive organosulfur compounds garlic, and its potential against various cancer models has been demonstrated. The poor solubility DADS in aqueous solutions limits uses clinical application. present study aimed to develop a novel formulation increase bioavailability therapeutic evaluate role combination with oxaliplatin (OXA) colorectal system. We prepared characterized PEGylated, (DCPDD), OXA (DCPDO) liposomes. anticancer these formulations was...

Centaurea is one of the most important genera within family Asteraceae. An investigation phytochemical composition bruguieriana using Gas-Chromatography coupled to Mass spectrometry (GC-MS) was performed. Antimicrobial activity evaluated minimum inhibitory concentration method (MIC) and validated by molecular docking for major compounds active fraction (1,10-di-epi-cubenol methyl 8-oxooctanoate) C. against three bacterial receptors (TyrRS, DNA gyrase, dihydrofolate reductase (DHFR))....

Folkloric herbal remedies play a significant role in modern medicine, with Solanum plants like S. schimperianum, cordatum, and nigrum being widely utilized traditional Saudi Arabian medicine. This study investigates the phytochemical antioxidant potential of these plants, addressing gap existing literature. Two extraction solvents, hydro-methanolic (HME) hydro-acetonic (HAE), were employed to evaluate total phenolic flavonoid content, identify polyphenolic compounds using RP-HPLC, analyze...