Plants bearing essential oils contribute to prevent or cure diseases and maintaining health. Essential oil (EO) prepared from the leaves of Citrus medica showed antimicrobial activity while EO obtained Salvia officinalis (Sage) is used as carminative, antispasmodic, antiseptic, astringent for treatment many other diseases. Several studies were conducted explore effect drying conditions on profile quantity. In current study, a comparison was performed EOs fresh, freeze-dried shade-dried...

Abstract Most synthetic immunomodulatory medications are extremely expensive, have many disadvantages and suffer from a lot of side effects. So that, introducing reagents natural sources will great impact on drug discovery. Therefore, this study aimed to comprehend the mechanism activity some plants via network pharmacology together with molecular docking in vitro testing. Apigenin, luteolin, diallyl trisulfide, silibinin allicin had highest percentage C-T interactions while, AKT1, CASP3,...

The critical function of dihydroorotate dehydrogenase (DHODH) in pyrimidine synthesis attracted a great interest throughout beyond decades. Inhibitors human DHODH (hDHODH) have validated efficacy for remedy many immunological diseases. Brequinar and leflunomide are examples such compounds. However, most immunosuppressive medications suffer from lot side effects accompanied by adverse metabolic disturbances toxicities. So that, immunomodulation utilizing natural products received the...

The polar fractions of the Juniperus species are rich in bioflavonoid contents. Phytochemical study fraction sabina aerial parts resulted isolation cupressuflavone (CPF) as major component addition to another two bioflavonoids, amentoflavone and robustaflavone. Biflavonoids have various biological activities, such antioxidant, anti-inflammatory, antibacterial, antiviral, hypoglycemic, neuroprotective, antipsychotic effects. Previous studies shown that metabolism elimination biflavonoids rats...

Obesity is associated with a number of serious medical complications, which are often referred to as the “insulin resistance syndrome”. The aim present study was performed investigate possible interaction between conventional drug used for management cholesterol and traditional herbal remedies on obesity. This carried through out: estimation blood test; Estimation serum tests; Determination oxidative stress biomarkers antioxidant enzymes activities in liver were assayed; Histopathological...

Background: A simple and sensitive thin-layer chromatographic method has been established for quantification of
 glycyrrhizin in Glycyrrhiza glabra rhizome baby herbal formulations by validated Reverse Phase HPTLC method.
 Materials Methods: RP-HPTLC Method was carried out using glass coated with RP-18 silica gel 60 F254S HPTLC
 plates methanol-water (7: 3 v/v) as mobile phase.
 Results: The developed plate scanned quantified densitometrically at 256 nm. Glycyrrhizin...

Hyperthyroidism is a common endocrine disorder associated with increased risk of cardiovascular complications and mortality. Although antithyroid drugs (ATDs) are approved as first line option for many hyperthyroidism cases, including pregnancy childhood, they exert significant toxic profile. Medicago sativa L. (alfalfa) also called "The father all food" was among the diet consumed by mares that gave birth to foals congenital hypothyroidism. Since, greenfeed accused development such...

Aim This study designated to investigate and compare the therapeutic effect of Ulva lactuca methanolic extract against oxidative stress (OS)-infertility induced by naturally occurring prooxidants (gossypol) selenium- vitamins A, C, E (selenium-ACE) drug.Methods Male infertility was in rat intraperitoneal injection 5 mg/kg gossypol eight times then treatment carried out with 100 ulva oral administration for one or two weeks, after this period OS, male infertile markers were detected blood...

Ulva lactuca is widespread green algae. In some regions, it used in nutrition. Its nutrients include iron, protein, iodine, vitamins (A, B1, and C) trace elements. Their extracts showed potential antibacterial, hypolipidemic, cardioprotective chemoprotective activities. The main chemical constituents of methanolic crude extract its fractions were investigated this study using different phytochemical chromatographic methods. Biologically guided fractionation plants or seaweeds considered the...

Diabetes mellitus (DM) is a chronic metabolic disorder. Streptozotocin naturally occurring cytotoxic chemical, particularly toxic to the pancreas and insulin producing beta cells in mammals induces diabetes. Glimepiride second generation sulfonylurea, used as second-line or add-on treatment options for type 2 Fenugreek (Trigonellafoenum graecum) seeds have been documented traditional plant Soluble dietary fiber of significantly improved oral glucose tolerance diabetic rats. It also exerts...

Lagenaria siceraria commonly known as bottle gourd, is a medicinal plant widely cultivated in African and Asian countries. It official Ayurvedic Pharmacopoeia. traditionally used nutritive agent having cardioprotective, cardiotonic, general tonic, diuretic, aphrodisiac, antidote to certain poisons, scorpion strings alternative purgative. cures pain, ulcers, fever for pectoral cough, asthma other bronchial disorders. also has various biological activities such as: anthelmintic,...

The genus Erythrina (family Fabaceae) comprises over 110 species of orange or red flowered trees, shrubs and herbaceous plants [1,2]. A phytochemical investigation the ethanolic extract caffra Thumb. flowers from an Egyptian origin yielded three C-flavonoidal glycosides; 5,7,4′-trihydroxyflavone-8-C-β-D-glucopyranoside (vitexin) (1), 5, 7, 4′-trihydroxyflavone-6, 8-di-C-β-D-glucopyranoside (vicenin-2) (2), 5,7,4′-trihydroxyflavone-6-C-β-D-glucopyranoyl-(1→2)-β-D-glucopyranoside...

Oxidative stress plays a major part in the development of cancer. While cancer is now recognized as one leading causes death world. This study has been undertaken to evaluate possible potential antioxidant effect different fractions Murraya Paniculata L. leaves cultivated Egypt seasons using DPPH scavenging method and assess their anticancer potential. Also, determine total flavonoidal content isolate compounds fraction alcoholic extract showed higher activity. Results screening activity...

Abstract Obesity can be defined as a condition of abnormal or excess fat accumulation in adipose tissue, to the extent that health may impaired. Fennel is one oldest spice plants which widely grows arid and semi-arid due its economic importance pharmaceutical industry usage. This plant has anti-inflammatory analgesic effect effective gastrointestinal disorder treatment. The aim present study was evaluate phytochemical characteristics therapeutic properties this medicinal plant. current...

In the literature, there is a scarcity of greener analytical approaches for colchicine (CLH) analysis. As result, efforts were made in this study to develop and validate reversed-phase high-performance thin-layer chromatography (HPTLC) technique CLH analysis traditional extracts (TE) ultrasonication-based (UBE) commercial Unani formulations, allopathic Colchicum autumnale Pleniflorum (L.) obtained from Egypt India. This new was compared regular normal-phase HPTLC method. The greenness...

This study aims to analyze the composition of essential oils Murraya paniculata L. leaves over four-season cycles using GC-MS investigate effect climate variation on chemical as well their activities.The yield oil obtained by hydrodistillation ranged from 0.02% 0.1% v/w; being highest in spring and lowest summer.GC-MS identified a total thirty-five components samples collected during four seasons with molecular weight ranging 202 296 m/z.In all samples, sesquiterpene hydrocarbons were...