Luteolin (LUT) is a natural flavonoid with low oral bioavailability restricted clinical applications due to its solubility. LUT shows significant anti-tumor activity in many cancer cells, including hepatocellular carcinoma (HCC). The most recent trend pharmaceutical innovations the application of phospholipid vesicles improve solubility such hydrophobic drugs. Ethosomes are one powerful used achieve that target. In this study, LUT-loaded ethosomal nanoparticles (LUT-ENPs) were prepared by...

Despite considerable advances in cancer treatment, chemotherapy remains a cornerstone breast therapy. Therefore, reducing chemoresistance and adverse effects of is priority. In this regard, Baicalin (BA) the dominant natural flavonoid extracted from roots Scutellaria baicalensis showed fascinating antitumor activity many types cancers, including cancer. The present study aimed to explore chemopreventive action baicalin alone combination with 5-FU addition its ability enhance effect on using...

Rosmarinic acid is a natural polyphenolic compound that found in different plant species and used for medicinal purposes. This study aimed to investigate the chemo-preventive effect of rosmarinic evaluate its antitumor efficacy alone or combination with Paclitaxel breast cancer mice model. Ehrlich induced mammary solid tumor model was study. Mice were treated oral intraperitoneal Paclitaxel. Inflammation, angiogenesis, apoptosis checked. Enzyme linked immunosorbent assay (ELISA),...

Previous metabolomics studies have proven the efficiency of infrared (IR) spectroscopy as a tool for authenticity assessment. Attenuated total reflectance – Fourier transform (ATR-FTIR), with principal component analysis (PCA) and bidirectional orthogonal projection to latent structures-discriminant (O2PLS-DA), was used create model discrimination N. sativa oil samples gathered from three geographical areas; Egypt, Ethiopia Syria. It is reported that, herbal drug treatments even equal...

Abstract This paper shows the development of an electrochemical sensor for sensitive estimation cariprazine (CRZ), FDA-approved drug to treat schizophrenia and acute manic. Voltammetric studies were developed utilizing a carbon paste electrode (CPE) modified with novel nanohybrid material composed silver zinc oxide nanoparticles (Ag/ZnO NPs) Prussian blue analogue (PBA, ZnTCNi/HCCo) that was prepared through chemical co-precipitation technique. Its structural, compositional, morphological...

Preclinical studies prove that short-term fasting secures healthy cells against chemotherapy side effects and makes malignant more vulnerable to them. This study aimed examine the of intermittent (IF) during adjuvant AC (doxorubicin, cyclophosphamide) protocol in breast cancer (BC) patients.Forty-eight newly diagnosed human epidermal growth factor receptor 2-negative (HER2 negative) BC patients were divided equally into two groups (24 each). The first group was recruited fast intermittently...

Abstract A simple, rapid, and low‐cost technique was developed to allow reliable analysis of the anti‐hepatitis C drug sofosbuvir in bulk, tablet form, spiked human plasma. This method depends on ability quench fluorescence newly synthesized 2‐amino‐3‐cyano‐4,6‐dimethylpyridine (reagent 3 ). Elemental spectral data were used validate structure reagent. The reagent exhibited a satisfactory level emission at 365 nm after excitation 247 nm. All experimental variables that might affect quenching...

Abstract Designing new validated analytical procedures with a focus on many objectives, such as simplicity, environmental friendliness, effectiveness, and sustainability, has grown to be top priority in quality control departments. Applying green white chemistry concepts is no longer luxury. In this report, two approaches, Capillary Zone Electrophoresis (CZE) Photo Diode Array (PDA) detection derivative ratio spectrophotometric methods, are established for the simultaneous analysis of...

Inflammatory bowel disease (IBD), consists of two primary types: Ulcerative Colitis (UC) and Crohn's Disease (CD). Infliximab (IFX) Adalimumab (ADA) are frequently utilized in the management moderate to severe cases IBD.

Hypolipidemic effect of Portulaca oleracea L. seed extract and its fractions have been studied on streptozotocin (STZ) at dose 75 mg/kg b.wt. After fractionation the alcoholic extract; petroleum ether fraction was most active that decreased different hyperlipidemia biochemical parameters. chromatographic analysis; oleamide, ethylpalmitate, β-amyrin, stigmasterol β-sitosterol were identified. The GLC analysis unsaponifiable matter revealed presence of; lignoceric acid as a major constituent...

Cyclophosphamide (CYP) is a chemotherapeutic agent with potent ovarian toxic effect. CYP induces granulosa cell apoptosis and oxidative stress. Irbesartan (IRB) unique ARB peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonistic activity. As PPAR-ɣ activation exerts anti-inflammatory effects reduces ROS production, IRB may further reduce inflammatory chemokine expression suppress apoptotic death. Therefore, this study aimed to evaluate the of on development CYP-induced damage....

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Terana GT, Abd-Alhaseeb MM, Omran GA, M. Okda T. Quercetin potentiates 5-fluorouracil effects in human colon cancer cells through targeting the Wnt/β-catenin signalling pathway: role of miR-27a. Contemporary Oncology/Współczesna Onkologia. 2022;26(3):229-238. doi:10.5114/wo.2022.120361. APA Terana, G. T., Abd-Alhaseeb, M., Omran, A., & Okda, (2022). Onkologia, 26(3), 229-238....

Type 2 diabetes mellitus (T2DM) is one of the most common diseases, that managed by several medications such as Glimepiride and Dapagliflozin. This study aims to compare effects Dapagliflozin versus on glycemic control, insulin resistance, biomarkers (extracellular domain regulated aminopeptidase) IRAPe, (interleukin-34) IL-34, (N-terminal pro b-type natriuretic peptide) NT-proBNP. included 60 type diabetic patients, who are randomized receive either 4 mg/day (group 1) or 10 2). Blood...

Benzyl isothiocyanate (BITC) is a member of the compounds that found in cruciferous vegetables. BITC has potential anticancer effect different types tumors. Few studies referred to antineoplastic against HCC. The mechanism concerning retardation HCC progression incompletely understood. This study evaluated role HGF, pAkt and STAT3 induced growth retardation. was mice using diethylnitrosamine (DEN) 75 mg/kg once week for 4 weeks. 10 20 given orally each day cell lines HepG2 Huh-7 were also...

Background: Despite advancements in cancer treatment, breast (BC) is still one of the leading causes death among women. The majority anti-breast-cancer medications induce serious side effects and multidrug resistance. Although several natural compounds, such as evening primrose oil (EPO), have been shown to anticancer properties when used alone, their combination with medicine tamoxifen (TAM) has yet be investigated. present study aimed investigate efficacy EPO, alone or TAM, BC cell lines...

A sensitive voltammetric technique for the determination of avanafil (AVA) has been investigated at a carbon paste electrode modified with Zinc oxide nanoparticles and multi-walled nanotubes (ZnO-NPs/MWCNT/CP). The study electrochemical behavior AVA, morphology was evaluated by transmission electron microscopy, scanning X-ray diffraction patterns. influence different electrodes content ZnO-NPs on AVA were evaluated. Square wave voltammetry studied linear correlation resulted within range...

The different parts of pomegranate fruit are considered a powerful mixture bioactive compounds yet the peels and pulps fruits usually discarded as industrial waste. In this work, ultra-performance liquid chromatography coupled with triple quadrupole mass spectrometry (UPLC-QqQ-MS) was utilized for metabolomics analysis (peel, pulp, seed juice) cultivars to verify possible variations among their waste products potential sources functional constituents.Orthogonal projection latent...