A5033659306- Nanoparticle-Based Drug Delivery
- Drug Solubulity and Delivery Systems
- Analytical Chemistry and Chromatography
- Advanced Drug Delivery Systems
- Pharmacological Effects of Natural Compounds
- Analytical Methods in Pharmaceuticals
- RNA Interference and Gene Delivery
- Inhalation and Respiratory Drug Delivery
- Computational Drug Discovery Methods
- Nigella sativa pharmacological applications
- Drug-Induced Hepatotoxicity and Protection
- Ginger and Zingiberaceae research
- Molecular Communication and Nanonetworks
- Virus-based gene therapy research
- Toxin Mechanisms and Immunotoxins
- Extracellular vesicles in disease
- Cancer Research and Treatments
- Phenothiazines and Benzothiazines Synthesis and Activities
- Gold and Silver Nanoparticles Synthesis and Applications
- Enzyme function and inhibition
- Polysaccharides Composition and Applications
- Micro and Nano Robotics
- CRISPR and Genetic Engineering
- Lipid Membrane Structure and Behavior
- Drug Transport and Resistance Mechanisms
King Saud University
2016-2025
Background: Bioactive oils of natural origin have gained huge interests from health care professionals and patients. Objective: To design a bioactive self-nanoemulsifying drug delivery system (Bio-SNEDDS) comprising curcumin (CUR) piperine (PP) by incorporating in the formulation. Methods: The self-emulsifying properties apricot, avocado, black seed Zanthoxylum rhetsa were screened within various SNEDDS formulations. Each liquid formulation was loaded with both CUR PP. optimal solidified...
Gefitinib (GEF) is utilized in clinical settings for the treatment of metastatic lung cancer. However, premature drug release from nanoparticles vivo increases exposure systemic organs to GEF. Herein, nanostructured lipid carriers (NLC) were not only avoid but also due their inherent lymphatic tropism. Therefore, present study aimed develop a GEF-NLC as delivery system with low release. Design experiments was stable The vitro GEF prepared formulations studied select optimum formulation. MTT...
The present study aimed to develop gefitinib-loaded solid lipid nanoparticles (GEF-SLN), and GEF-loaded PEGylated SLN (GEF-P-SLN) for targeting metastatic lung cancer through the lymphatic system.The prepared SLNs were characterized in terms of physicochemical properties, entrapment efficiency, in-vitro release. Furthermore, ex-vivo permeability was investigated using rabbit intestine. Cytotoxicity apoptotic effects studied against A549 cell lines as a model cancer.The results revealed that...
Many clinical trials have shown the effectiveness of combination therapy over monotherapy in diabetes management. Sitagliptin (SG) and metformin (MF) are most common combinations for type II These drugs were combined into one tablet, called Janumet 50/850 (SG/MF). The pharmaceutical industry constantly demands a rapid, simple, sensitive, valid analytical method simultaneously determining products. Therefore, this study aims to develop an ultraperformance liquid chromatography concurrently...
Self nano-emulsifying drug delivery system (SNEDDS) has been widely used to enhance dissolution and bioavailability of glibenclamide (GB). In addition, black seed oil, containing bioactive thymoquinone (TQ), showed promising antihyperglycemic effect. Therefore, this work aims design solid SNEDDS formulation composed Black oil loaded with GB its activity. Different formulations were prepared characterized for miscibility, dispersibility, droplet size, zeta potential, in-vitro dissolution....
Thiourea derivatives bearing sulfonamide moiety are well known for their anticancer activity.The activity of the target compounds was studied, via inhibition COX-2 enzyme.A series novel thioureas 5a-n, 8, quinazoline 6, benzo[g]quinazoline 7 and benzo[1,3] dioxole 10, a synthesized from starting compound N-(2,6-dimethoxypyrimidin-4-yl)-4- isothiocyanatobenzenesulfonamide 2. The were screened against HepG2, MCF-7, Caco-2, HCT-116, PC-3 cancer cell lines VERO-B normal line.Out all tested...
This study was conducted to formulate, characterize, and investigate the bioavailability of hydrocortisone (HCT) when prepared as solid dispersions. HCT mixed in an organic solvent with polyethylene glycol 4000 (PEG 4000) Kolliphor® P 407. Spray drying technique employed form a dispersion formulation at specific ratio. Physical chemical characterization formed particles were achieved using differential scanning calorimetry, electron microscopy, Fourier transform infrared spectroscopy, powder...
Purpose: Ramipril (RMP)—an angiotensin-converting enzyme (ACE) inhibitor—and thymoquinone (THQ) suffer from poor oral bioavailability. Developing a combined liquid SNEDDS that comprises RMP and black seed oil (as natural source of THQ) could lead to several formulations therapeutic benefits. Methods: The present study involved comprehensive optimization RMP/THQ using self-emulsification assessment, equilibrium solubility studies, droplet size analysis, experimentally designed phase diagrams....
Atorvastatin (AT) is widely prescribed by physicians during the treatment of hyperlipidemia. The self-nanoemulsifying drug delivery system (SNEDDS) used to overcome its low solubility and bioavailability. However, presence free fatty acids in SNEDDS formulation resulted remarkable AT degradation. This study explores innovative carbonated enhance stability within formulation. Various types formulations were prepared evaluated. In vitro dissolution was performed examine ability dissolution....
Objective Ginger (Zingiber officinale Roscoe) is considered to be one of the most commonly consumed dietary condiments world. The present study was designed explicate protective role zingerone; an active ingredient ginger in complete Freund's adjuvant (FCA)-immunized arthritic rats.Methods 24 Wistar rats were divided into 4 groups with 6 each. Group I as control followed by group II, III and IV treated single intradermal injection FCA (0.1 ml = 100 µg) induce rheumatoid arthritis. also...
Lansoprazole (LZP) is used to treat acid-related gastrointestinal disorders; however, its low aqueous solubility limits oral absorption. Black seed oil (BSO) has gastroprotective effects, making it a promising addition gastric treatment regimens. The present study aims develop stable multifunctional formulation integrating solid dispersion (SD) technology with bioactive self-nanoemulsifying drug delivery system (SNEDDS) based on BSO synergistically enhance LZP and therapeutic effects....
The urinary bladder stores urine until the time of urination. Systemic administration drugs to treat diseases faces several limitations. Therefore, intravesical drug delivery is a promising alternative route administration. An in-situ gel used form inside cavity and ensure continuous release even after objective present study was optimize an formulation poloxamer chitosan for ketorolac tromethamine. gelling temperature prepared combinations ranged from 20.67 25.8 °C. In-vitro KT sustained up...
Lung cancer is a formidable challenge in clinical practice owing to its metastatic nature and resistance conventional treatments. The codelivery of anticancer agents offers potential solution overcome minimize systemic toxicity. encapsulation these within nanostructured lipid carriers (NLCs) provides promising strategy enhance lymphatic delivery reduce the risk relapse. This study aimed develop an NLC formulation loaded with Gefitinib Azacitidine (GEF-AZT-NLC) for treatment...
Metabolic syndrome is an associated condition that occurs together and increases the risk of heart disease diabetes. These conditions include high blood pressure, sugar, body mass index (BMI) in terms cholesterol triglyceride levels. Most elderly population may administer three drugs to control above conditions. Therefore, this study aims develop analytical assay for precise analysis components formulate a Self-Nanoemulsifying Drug-Delivery System (SNEDDS) loaded with drugs: Rosuvastatin...