A5033161750- Synthesis and biological activity
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Bioactive Compounds and Antitumor Agents
- Synthesis and Biological Evaluation
- Cancer, Lipids, and Metabolism
- Cancer therapeutics and mechanisms
- Cancer-related Molecular Pathways
- Natural product bioactivities and synthesis
- Cancer Treatment and Pharmacology
- Organic Chemistry Cycloaddition Reactions
- Cancer Mechanisms and Therapy
- Click Chemistry and Applications
- Nanoparticles: synthesis and applications
- Genomics, phytochemicals, and oxidative stress
- Phytochemical compounds biological activities
- Organoselenium and organotellurium chemistry
- Curcumin's Biomedical Applications
- Marine Biology and Environmental Chemistry
- Ferrocene Chemistry and Applications
- Nanoparticle-Based Drug Delivery
- Vitamin D Research Studies
- Synthesis of Tetrazole Derivatives
- DNA and Nucleic Acid Chemistry
- Cholinesterase and Neurodegenerative Diseases
Mansoura University
2015-2025
Sylvester Comprehensive Cancer Center
2022-2025
Suez Canal University
2023
South Dakota State University
2015
King Abdulaziz University
2014
Spirooxindole is a promising chemo therapeutic agent. Possible targets include cancers of the liver, prostate, lung, stomach, colon, and breast. Here, we demonstrate one-pot three-component reaction via [3 + 2] cycloaddition/ring contraction sequence dipolarophile (activated alkene) with in situ-generated azomethine ylide (1,3-dipoles) without use any catalyst. The provides efficient access to synthetically useful biologically important spirooxindoles high yield (69-94%)...
Ovarian cancer is the most deadly gynecological cancer. The first line in treatment platinum-based drugs. However, patients suffer from tumor recurrence, characterized by resistance to cisplatin. A plausible approach address co-administer chemotherapeutic agents along with natural products offer a synergistic effect and optimize dosage regimen. Cucurbitacin B product displays antitumor activity against wide array of cell lines. aim this work determine ovarian (A2780) possible sensitization...
Hepatocellular carcinoma is a highly aggressive and difficult-to-treat type of cancer. Incorporating urea functionality into the backbone organoselenium compounds expected to develop promising chemotherapeutic leads against liver Methods: Urea-functionalized were synthesized in good yields, their cytotoxicity was evaluated HepG2 cells. Results: 1,1'-(Diselanediylbis(4,1-phenylene))bis(3-phenylurea) (14) exhibited efficient anti-HepG2 activity sub-micromolar concentrations, with no toxicity...
Objectives: This in vivo study introduces a newly developed spirooxindole derivative that is deemed safe and effective as potential targeted therapy for various cancers. Methods: Extensive investigations, including histopathology, immunohistochemistry, molecular biology, validated its further preclinical clinical exploration, necessitating comprehensive examinations of bioavailability, pharmacodynamics, pharmacokinetics. Additionally, this involves the development commercially viable...
Thiourea derivatives bearing sulfonamide moiety are well known for their anticancer activity.The activity of the target compounds was studied, via inhibition COX-2 enzyme.A series novel thioureas 5a-n, 8, quinazoline 6, benzo[g]quinazoline 7 and benzo[1,3] dioxole 10, a synthesized from starting compound N-(2,6-dimethoxypyrimidin-4-yl)-4- isothiocyanatobenzenesulfonamide 2. The were screened against HepG2, MCF-7, Caco-2, HCT-116, PC-3 cancer cell lines VERO-B normal line.Out all tested...
A one-pot, single-step, and an atom-economical process towards the synthesis of highly functionalized spirooxindoles analogues was efficiently conducted to produce a satisfactory chemical yields (70–93%) with excellent relative diastereo-, regio-selectivity. An in vitro antiproliferative assay carried out on different cancer cell lines evaluate biological activity synthesized tetrahydro-1’H-spiro[indoline-3,5’-pyrrolo[1,2-c]thiazol]-2-one 5a–n. The prepared hybrids were then tested for their...
The low amount of metabolites isolated from natural products is one the challenges preventing their biological evaluation. modulation biosynthetic pathways by stimulating stress-induced responses in plants was proven to be a valuable tool for diversification already known products. Recently, we reported dramatic effect methyl jasmonate (MeJA) on Vinca minor alkaloids distribution. In this study, three compounds identified as 9-methoxyvincamine, minovincinine, and minovincine are successfully...
In this work, the natural piperine moiety was utilised to develop two sets of piperine-based amides (5a-i) and ureas (8a-y) as potential anticancer agents. The action assessed against triple negative breast cancer (TNBC) MDA-MB-231, ovarian A2780CP hepatocellular HepG2 cell lines. particular, 8q stood out most potent anti-proliferative analogue TNBC MDA-MB-231 cells with IC50 equals 18.7 µM, which is better than that (IC50 = 47.8 µM) 5-FU 38.5 µM). Furthermore, investigated for its possible...
Abstract A novel series of coumarin‐thiadiazole heterocycle derivatives was synthesized by the nucleophilic substitution reaction. The compounds were structurally verified IR, 1 H NMR, 13 C mass spectra, and elemental analyses. antitumor activity evaluated through DNA binding assays 60‐cell line panel according to US NCI‐DTP protocol or a selection human tumor cell lines: breast cancer (MCF‐7), liver (HepG‐2), colorectal (HCT‐116). Most had better DNA/ethidium bromide fluorescence quenching...
Acetylcholinesterase inhibitors (AChE-Is) increase both level and duration of action acetylcholine (ACh); thus, alleviate symptoms Alzheimer's disease (AD). Glycyrrhizin, is the main active compound in liquorice root. Its aglycone, glycyrrhetinic acid, has shown several beneficial pharmacological activities. This study reports synthesis screening a series acid analogs as AChE-Is. Fourteen derivatives were prepared, which five are recorded new viz., 3-phenyl-carbamoyl-18β-glycyrrhetinic (J9),...
We herein report a new small library of Schiff-base compounds that encompasses s-triazine and (2 or 4)-hydroxylbenzylidene derivatives. These were synthesized through hydrazone linkage connecting both the hydroxybenzylidene The synthetic strategy adopted allowed synthesis target with excellent yields purities as observed from their NMR ( 1 H 13 C) elemental analysis. Furthermore, 4f , 5b 5f further confirmed by X-ray single crystal diffraction technique. preliminary antiproliferative...
Over the past few decades, development of broad-spectrum anticancer agents with anti-angiogenic activity has witnessed considerable progress. In this study, a new series pyrazolo[3,4-d]pyrimidines based on phenylfuroxan scaffold were designed, synthesized, and evaluated, in terms their activities. NCI-60 cell one-dose screening revealed that compounds
Myxofibrosarcoma (MFS) is a common soft tissue sarcoma of the elderly that typically shows low tumor mutational burden, with mutations in TP53 and genes associated cell cycle checkpoints ( RB1 , CDKN2A ). Unfortunately, no alterations or markers specific to MFS have been identified and, as consequence, there are effective targeted therapies. The receptor tyrosine kinase AXL, which drives cellular proliferation, targetable by new antibody-based therapeutics. Expression AXL messenger RNA...