A5027056120- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Metal complexes synthesis and properties
- Crystallography and molecular interactions
- Crystal structures of chemical compounds
- Synthesis and Biological Evaluation
- Multicomponent Synthesis of Heterocycles
- Organic Chemistry Cycloaddition Reactions
- Synthesis of heterocyclic compounds
- Bioactive Compounds and Antitumor Agents
- Click Chemistry and Applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Metal-Organic Frameworks: Synthesis and Applications
- Nonlinear Optical Materials Research
- Quinazolinone synthesis and applications
- Asymmetric Synthesis and Catalysis
- Cancer-related Molecular Pathways
- Synthesis and Reactivity of Heterocycles
- Computational Drug Discovery Methods
- Free Radicals and Antioxidants
- Cancer therapeutics and mechanisms
- Synthesis and Reactions of Organic Compounds
- Structural and Chemical Analysis of Organic and Inorganic Compounds
Alexandria University
2014-2025
King Saud University
2016-2025
Mansoura University
2016-2021
Damietta University
2013-2016
Universiti Sains Malaysia
2016
Institute of Medicinal Plant Development
2016
Université Hassan II Mohammedia
2016
The King's College
2015
Chonbuk National University Hospital
2013
ETH Zurich
2009
A multicomponent synthesis was empolyed for the of ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 1. An interesting cyclization obtained when amino-ester 1 reacted with isothiocyanate to give benzo[4,5]thieno[2,3-d][1,3]thiazin-4-one 3. Acylation chloroacetyl chloride in DCM and Et3N afforded acylated ester 4. The cyclized benzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one 8, which some alkylating agents leading alkylation at nitrogen 9–13. Hydrazide 14 utilized as a synthon...
Systematic studies have been performed to develop highly efficient catalysts for the asymmetric aza-Claisen rearrangement of trihaloacetimidates. Herein, we describe stepwise development these catalyst systems involving four different generations finally resulting in a planar chiral pentaphenylferrocenyl oxazoline palladacycle. This complex is more reactive and has broader substrate tolerance than all previously known rearrangements. Our investigations also reveal that subtle changes can big...
[NiCl2(C14H12N2)(H2O)] complex has been synthesized from nickel chloride hexahydrate (NiCl2·6H2O) and 2,9-dimethyl-1,10-phenanthroline (dmphen) as N,N-bidentate ligand. The was characterized by elemental analysis, infrared (IR) spectroscopy, ultraviolet-visible (UV-vis) spectroscopy differential thermal/thermogravimetric analysis (TG/DTA). further confirmed single crystal X-ray diffraction (XRD) triclinic with space group P-1. desired complex, subjected to thermal decomposition at low...
The derivatives of thieno[2,3-b]thiophene belong to a significant category heterocyclic compounds, which have shown wide spectrum medical and industrial application.A new building block with two electrophilic center 2 has been reported by one-pot reaction diketone derivative 1 Br2/AcOH in excellent yield. A variety heteroaromatics having bis(1H-imidazo[1,2a] benzimidazole), bis(1H-imidazo[1,2-b][1,2,4]triazole)-3-methyl-4-phenylthieno[2,3-b]thiophene derivatives, dioxazolo-, dithiazolo-,...
Spirooxindole is a promising chemo therapeutic agent. Possible targets include cancers of the liver, prostate, lung, stomach, colon, and breast. Here, we demonstrate one-pot three-component reaction via [3 + 2] cycloaddition/ring contraction sequence dipolarophile (activated alkene) with in situ-generated azomethine ylide (1,3-dipoles) without use any catalyst. The provides efficient access to synthetically useful biologically important spirooxindoles high yield (69-94%)...
Here, we synthesized a newseries of mono- and bis(dimethylpyrazolyl)-s-triazine derivatives. The synthetic methodology involved the reaction different dihydrazinyl-s-triazine derivatives with acetylacetone in presence triethylamine to produce corresponding target products high yield purity. antiproliferative activity novel was studied against three cancer cell lines, namely, MCF-7, HCT-116, HepG2. N-(4-Bromophenyl)-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-morpholino-1,3,5-triazin-2-amine 4f,...
Schiff bases of chitosan (CS) were prepared by reaction four different heterocyclic compounds, namely, 1,3-dimethyl-2,4,6-trioxohexahydropyrimidine-5-carbaldehyde (M1), 3-acetyl-2H-chromen-2-one (M2), 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde (M3), and 4-oxo-4H-chromene-3-carbaldehyde (M4), with CS using thermal ultrasound approaches. base formation was confirmed FT-IR, XRD, TGA. Characteristic data show that amino groups in reacted the functional group compound to form base....
Abstract Recently, cancer research protocols have introduced clinical-stage spirooxindole-based MDM2 inhibitors. However, several studies reported tumor resistance to the treatment. This directed efforts invest in designing various combinatorial libraries of spirooxindoles. Herein, we introduce new series spirooxindoles via hybridization chemically stable core spiro[3 H -indole-3,2′-pyrrolidin]-2(1 )-one and pyrazole motif inspired by lead pyrazole-based p53 activators, inhibitor BI-0252...
The development of effective therapy for eradicating glioblastoma stem cells remains a major challenge due to their aggressive growth, chemoresistance and radioresistance which are mainly conferred by aldehyde dehydrogenase (ALDH)1A1. latter is the main stemness mediator via enhancing signaling pathways Wnt/β-catenin, phosphatidylinositol 3-kinase/AKT, hypoxia. Furthermore, ALDH1A1 mediates therapeutic resistance inactivating drugs, stimulating expression drug efflux transporters,...
Cancer represents a global challenge, and the pursuit of developing new cancer treatments that are potent, safe, less prone to drug resistance, associated with fewer side effects poses significant challenge in research discovery. Drawing inspiration from pyrrolidinyl-spirooxindole natural products, novel series spirooxindoles has been synthesized through one-pot three-component reaction, involving [3 + 2] cycloaddition reaction. The cytotoxicity against breast cells (MCF-7 MDA-MB-231) safety...
Two dicationic water soluble mixed triamine/diamine copper (II) complexes, of general formula [Cu(dien)NN]Br2 (1–2) [dien = diethelenetriamine and NN is en ethylenediamine or Me4en N,N′,N,N′-tetramethylethylenediamine] were prepared under ultrasonic mode with a relatively high yield. These complexes characterized by elemental microanalysis, UV visible IR spectroscopy, thermal electrochemical techniques. In addition, complex 2 structure was solved X-ray single crystal Hirshfeld surface...
Due to their structural and therapeutic diversity, thienothiophene derivatives have attracted much synthetic interest because of reactivity biological activity. The thieno [2,3-b] thiophene moiety has been used in the design a novel pharmaceutical therapies. Additionally, its enaminones are versatile synthons lot applications such as N-heterocycles, wide variety naturally occurring alkaloids drugs.Synthesis (2E,2'E)-1,1'-(3,4-diphenylthieno thiophene-2,5-diyl) bis (3-(dimethylamino)...
A series of new spiro-heterocycles engrafted spirooxindole/pyrrolidine/thiochromene scaffolds was synthesized by the three-component 1,3-dipolar cycloaddition reactions in a fully controlled regio- and stereo-selective fashion. Condensation several substituted isatin derivatives with L-proline generated azomethine ylides which subsequently reacted chalcones based thiochromene scaffold, finally afforded target spiro-compounds. This simple protocol furnished structurally complex, biologically...
The tumor resistance to p53 activators posed a clinical challenge. Combination studies disclosed that concomitant administration of Bcl2 inhibitors can sensitize the cells and induce apoptosis. In this study, we utilized rapid synthetic route synthesize two novel hybrid spirooxindole-based p53-MDM2 endowed with signaling attenuation. adducts mimic thematic features chemically stable potent spiro [3
A new series of spirooxindoles based on ethylene derivatives having furan aryl moiety are reported. The hybrids were achieved via [3 + 2] cycloaddition reaction as an economic one-step efficient approach. final constructed have four contiguous asymmetric carbon centers. structure 3a is exclusively confirmed using X-ray single crystal diffraction. supramolecular controlled by O···H, H···H, and C···C intermolecular contacts. It includes layered molecules interconnected weak C-H···O (2.675 Å),...