A5030297166- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Research on Leishmaniasis Studies
- Quinazolinone synthesis and applications
- Click Chemistry and Applications
- Synthesis of heterocyclic compounds
- Synthesis and Reactions of Organic Compounds
- Nanoparticle-Based Drug Delivery
- Multicomponent Synthesis of Heterocycles
- Computational Drug Discovery Methods
- Malaria Research and Control
- Bioactive Compounds and Antitumor Agents
- Inflammatory mediators and NSAID effects
- Nanoplatforms for cancer theranostics
- Trypanosoma species research and implications
- Analytical Methods in Pharmaceuticals
- Essential Oils and Antimicrobial Activity
- RNA Interference and Gene Delivery
- Marine Sponges and Natural Products
- Chemical synthesis and pharmacological studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Protein Hydrolysis and Bioactive Peptides
- Synthesis of Organic Compounds
- Echinoderm biology and ecology
Alexandria University
2016-2025
University of Bahrain
2018-2025
University College of Bahrain
2018-2022
Addis Ababa University
2010-2022
Egypt Nanotechnology Center
2022
University of Otago
2014-2021
Saarland University
2017
Universitätsklinikum des Saarlandes
2016
Institut für Medizinische Informatik, Biometrie und Epidemiologie
2016
King Abdulaziz University
2015
Marine shell waste is a very rich source of several bioactive compounds and materials, such as calcium, chitin, pigments, proteins. Currently, this material greatly underutilized contributes to significant environmental problems due off-odor concentration minerals in landfill. The main objective review highlight the potential add value maximize utilization stream. Therefore, provides up-to-date information on various available marine shells that are generated coproduct from commercial...
Abstract Pyrazole-bearing compounds are known for their diverse pharmacological effects including potent antileishmanial and antimalarial activities. Herein, some hydrazine-coupled pyrazoles were successfully synthesized structures verified by employing elemental microanalysis, FTIR, 1 H NMR techniques. The in vitro vivo activities of the pyrazole derivatives ( 9–15 ) evaluated against Leishmania aethiopica clinical isolate Plasmodium berghei infected mice, respectively. result revealed that...
Four series of 1H-pyrazole derivatives have been synthesized. The first was synthesized starting by condensing the hydrazine 1a-d with 4-(1-ethoxycarbonyl-2-oxopropyl)azobenzoic acid 2a in ethanol or glacial acetic to generate corresponding pyrazoline 3a-d. Likewise, heating 4-(1-acetyl-2-oxopropyl)azobenzoic 2b gave rise pyrazole 4a-d. Similarly, reaction ethyl 2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylazo)-3-oxobutanoate 2c...
This study investigated some physicochemical properties of keratin extracted from Merino wool using five chemical extraction methods: alkali hydrolysis, sulfitolysis, reduction, oxidation, and ionic liquid. The liquid method produced the highest protein yield (95%), followed by sulfitolysis (89%), while was obtained with reduction (54%). lowest oxidation (6%). extract contained higher molecular weight (>40 kDa) components, whereas hydrolysis material <10 kDa. extracts various...
Multireservoir nanocarriers were fabricated for delivering antineoplastic drug cocktail from herbal and fungal origin. Monascus yellow pigments (MYPs), monascin ankaflavin, isolated red-mold rice, incorporated within casein micelles (CAS MCs) along with the drug, resveratrol (RSV). Both drugs (MYPs RSV) simultaneously into hydrophobic core of CAS MCs. Alternatively, MYPs-loaded MCs enveloped RSV-phytosomal bilayer elaborating multireservoir nanocarriers.Cytotoxicity studies confirmed...
The development of new COX-2 inhibitors with analgesic and anti-inflammatory efficacy as well minimal gastrointestinal, renal cardiovascular toxicity, is vital importance to patients suffering from chronic course pain inflammatory conditions. This study aims at evaluating the therapeutic activity adverse drug reactions associated use newly synthesized pyrazole derivative, compound AD732, E-4-[3-(4-methylphenyl)-5-hydroxyliminomethyl-1H-pyrazol-1-yl]benzenesulfonamide, compared indomethacin...
Here, we synthesized a newseries of mono- and bis(dimethylpyrazolyl)-s-triazine derivatives. The synthetic methodology involved the reaction different dihydrazinyl-s-triazine derivatives with acetylacetone in presence triethylamine to produce corresponding target products high yield purity. antiproliferative activity novel was studied against three cancer cell lines, namely, MCF-7, HCT-116, HepG2. N-(4-Bromophenyl)-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-morpholino-1,3,5-triazin-2-amine 4f,...
While the treatment regimen of certain types breast cancer involves a combination hormonal therapy and chemotherapy, outcomes are limited due to difference in pharmacokinetics both agents that hinders their simultaneous selective delivery cells. Herein, we report hybrid carrier system for targeted aromatase inhibitor exemestane (EXE) methotrexate (MTX). EXE was physically loaded within liquid crystalline nanoparticles (LCNPs), while MTX chemically conjugated lactoferrin (Lf) by carbodiimide...