A5054250208- Microbial Metabolism and Applications
- Antibiotic Resistance in Bacteria
- Advancements in Transdermal Drug Delivery
- Nanoparticles: synthesis and applications
- Advanced Drug Delivery Systems
- Natural product bioactivities and synthesis
- Algal biology and biofuel production
- Selenium in Biological Systems
- Nanoparticle-Based Drug Delivery
- Lipid Membrane Structure and Behavior
- Dental Health and Care Utilization
- Calpain Protease Function and Regulation
- Bone Tissue Engineering Materials
- Antibiotic Use and Resistance
- Natural Antidiabetic Agents Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Phytase and its Applications
- Biochemical and Structural Characterization
- Laser-Ablation Synthesis of Nanoparticles
- Pharmacogenetics and Drug Metabolism
- Pharmaceutical and Antibiotic Environmental Impacts
- Steroid Chemistry and Biochemistry
- Bacterial biofilms and quorum sensing
- Crystallization and Solubility Studies
- Surfactants and Colloidal Systems
Taif University
2020-2024
Alexandria University
2018
Multireservoir nanocarriers were fabricated for delivering antineoplastic drug cocktail from herbal and fungal origin. Monascus yellow pigments (MYPs), monascin ankaflavin, isolated red-mold rice, incorporated within casein micelles (CAS MCs) along with the drug, resveratrol (RSV). Both drugs (MYPs RSV) simultaneously into hydrophobic core of CAS MCs. Alternatively, MYPs-loaded MCs enveloped RSV-phytosomal bilayer elaborating multireservoir nanocarriers.Cytotoxicity studies confirmed...
Inappropriate use of antibiotics in clinical settings is thought to have led the global emergence and spread multidrug-resistant pathogens. The goal this study was investigate prevalence genes encoding aminoglycoside resistance plasmid-mediated quinolone among isolates Klebsiella pneumoniae . All K. were phenotypically identified using API 20E then confirmed genotypically through amplification specific phoE gene. genotyped by enterobacterial repetitive intergenic consensus polymerase chain...
Colorectal cancer (CRC) is considered one of the most commonly diagnosed malignant diseases. Recently, there has been an increased focus on using nanotechnology to resolve limitations in conventional chemotherapy. Niosomes have great advantages that overcome drawbacks associated with other lipid drug delivery systems. They are simple, cheap, and highly stable nanocarriers. This study investigated effectiveness niosomes their amphiphilic characteristics incorporation both hydrophilic...
The emergence of carbapenem-resistant K. pneumoniae (CRKP) continues to escalate and is alarming because the pan drug-resistant strains. objective this study was investigate existence 12 carbapenemase genes among CRKP clinical isolates.Ninety-six Klebsiella spp. isolates were collected. identified phenotypically genotypically. These screened for susceptibility 24 different antibiotics. modified Hodge test (MHT) Carba Nordmann/Poirel (NP) used screen strains production. Phenotypic...
Nanobiotechnological approaches can provide effective solutions for overcoming food products' contamination and spoilage.
Monascin and ankaflavin, the major fractions of fungal-derived monascus yellow pigments, were incorporated with herbal drug, resveratrol (RSV) within core folate-conjugated casein micelles (FA-CAS MCs, F1) for active targeting. PEGylated RSV-phospholipid complex bilayer enveloping casein-loaded (PEGPC-CAS MCs) also developed as passive-targeted nanosystem.FA- PEGPC-CAS MCs demonstrated a proper size monomodal distribution, sustained drug release profiles good hemocompatibility. The coloaded...
Schizophrenia is a mental disorder characterized by alterations in cognition, behavior and emotions. Oral olanzapine (OZ) administration extensively metabolized (~up to 40% of the administrated dose). In addition, OZ P-glycoproteins substrate that impairs blood-brain barrier (BBB) permeability. To direct brain minimize its systemic side effects, nasal pathway recommended. OZ-loaded polymeric micelles nano-carriers were developed using suitable biodegradable excipients. The physicochemically...
Cholesterol oxidases (CHOXs) are flavin-adenine dinucleotide-dependent oxidoreductases with a range of biotechnological applications. There remains an urgent need to identify novel CHOX family members meet the demands enzyme markets worldwide. Here, we report cloning, heterologous expression, and structural modeling cholesterol oxidase Acinetobacter sp. strain RAMD. The gene was cloned expressed in pGEM®-T pET-28a(+) vectors, respectively, using gene-specific primer based on putative ORF...
The objective of this study was to create a fermentation process for the production inulinase, an important enzyme with numerous applications in food and pharmaceutical industries, using low-cost agricultural waste as substrates Rhizopus oryzae NRRL 3563. High titer inulinase chicory roots by submerged culture accomplished statistical experimental design. A two-level Plackett–Burman design followed three-level Box–Behnken producing high 1085.11 U/mL, 2.83-fold maximum level, obtained...
Hospital-acquired infections caused by P. aeruginosa contribute to global distress because of the elevated rates microbial antibiotic resistance. Aminoglycosides are antipseudomonal agents that effectively and frequently utilized eradicate this infection. This current study is a retrospective investigating plasmid-mediated aminoglycoside resistance focusing on prevalence genes encoding aminoglycoside-modifying enzymes (AMEs) 16S rRNA methylase among clinical isolates from Taif, Saudi Arabia....
Dental caries is an infectious oral disease caused by the presence of different bacteria in biofilms. Multidrug resistance (MDR) a major challenge dental treatment. Swabs were taken from 65 patients with Makkah, Saudi Arabia. cultivated on mitis salivarius agar and de Man, Rogosa, Sharpe (MRS) agar. VITEK 2 was used for identification isolated bacteria. Antibiotic susceptibility testing performed using commercial antibiotic disks. Ulva lactuca as reducing agent cellulose source to create...
Type 2 diabetes mellitus (T2DM) is a complex, multifactorial metabolic disorder mainly characterized by chronic hyperglycemia. It has become significant, serious disease worldwide, presenting huge risk to human life and health. This study aimed investigate the hypoglycemic effect of Lactobacillus casei ATCC 7469 fermented soy flour extract Chlorella vulgaris on Sprague-Dawley rats with T2DM induced low-dose streptozotocin administration (STZ) compared pioglitazone as reference drug....
Abstract Background T2DM is a polygenic, metabolic complex and multifactorial disease. Several genes contribute to risk of type 2 diabetes syndrome among different populations. Results An relationship between three identified CAPN-10 variants [ SNP-43 (rs#3792267), SNP-19 (rs#3842570) SNP-63 (rs#5030952 )] localized on 2q37 diabetic patients with without (MS) have been reported in our comparative study (diabetic vs health control individuals). Genotyping cohorts was carried out using...
The search for novel plant-based antioxidant and antibacterial medication has garnered a lot of attention lately. Glycyrrhiza glabra, known as licorice, is one the most important medicinal plants. primary component glabra glycyrrhizin, which biotransformed into 18α- 18β-glycyrrhetinic acid variety purposes. goal this study was to improve bioavailability glycyrrhizin by its biotransformation glycyrrhetinic Aspergillus niger. process optimized using response surface methodology. A two-level...